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Gucy2f Gene Detail
Summary
  • Symbol
    Gucy2f
  • Name
    guanylate cyclase 2f
  • Synonyms
    GC2, GC-F
  • Feature Type
    protein coding gene
  • IDs
    MGI:105119
    NCBI Gene: 245650
  • Gene Overview
    MyGene.info: GUCY2F
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:142081160-142196931 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 62.85 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    436 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105119
protein coding gene ChrX:142079289-142197276 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036147
protein coding gene ChrX:139582246-139698870 (-)
A/J MGP_AJ_G0036124
protein coding gene ChrX:138985988-139099334 (-)
AKR/J MGP_AKRJ_G0036050
protein coding gene ChrX:143424403-143545929 (-)
BALB/cJ MGP_BALBcJ_G0036115
protein coding gene ChrX:137219935-137330061 (-)
C3H/HeJ MGP_C3HHeJ_G0035823
protein coding gene ChrX:139690005-139799494 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036638
protein coding gene ChrX:143590343-143717150 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033462
protein coding gene ChrX:130561803-130663946 (-)
CAST/EiJ MGP_CASTEiJ_G0035114
protein coding gene ChrX:120409041-120510105 (-)
CBA/J MGP_CBAJ_G0035800
protein coding gene ChrX:148081426-148199958 (-)
DBA/2J MGP_DBA2J_G0035958
protein coding gene ChrX:138044695-138169139 (-)
FVB/NJ MGP_FVBNJ_G0035892
protein coding gene ChrX:137271785-137386713 (-)
LP/J MGP_LPJ_G0036049
protein coding gene ChrX:140530021-140645561 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035928
protein coding gene ChrX:155690595-155813649 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036675
protein coding gene ChrX:138890295-139002325 (-)
PWK/PhJ MGP_PWKPhJ_G0034808
protein coding gene ChrX:117218344-117333398 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034633
protein coding gene ChrX:120925993-121030568 (-)
WSB/EiJ MGP_WSBEiJ_G0035249
protein coding gene ChrX:137296390-137402276 (-)



Homology
more
  • Human Ortholog
    GUCY2F, guanylate cyclase 2F, retinal
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GUCY2F, guanylate cyclase 2F, retinal
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CYGF, GC-F, GUC2DL, GUC2F, RETGC-2, ROS-GC2
  • Links
    NCBI Gene ID: 2986
    neXtProt AC: NX_P51841
    UniProt: P51841

  • Chr Location
    Xq22.3-q23; chrX:109372061-109482056 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    1 images
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal retinal rod electrophysiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042282 Ensembl Gene Model | MGI Sequence Detail 115772 C57BL/6J ±  kb
transcript ENSMUST00000042530 Ensembl | MGI Sequence Detail 8122 Not Applicable  
polypeptide ENSMUSP00000044521 Ensembl | MGI Sequence Detail 1108 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 11
    Primer pair 2

    Microarray probesets 1
Other
Accession IDs
less
MGD-MRK-32159
References
more
  • Summaries
    All 34
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:31346 Yang RB, et al., Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina. Genomics. 1996 Feb 1;31(3):367-72
  • Latest
    J:236923 Peshenko IV, et al., Functional Study and Mapping Sites for Interaction with the Target Enzyme in Retinal Degeneration 3 (RD3) Protein. J Biol Chem. 2016 Sep 9;291(37):19713-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory