Gucy2f
Gene Detail

Symbol Name ID

Gucy2f guanylate cyclase 2f MGI:105119

Synonyms

GC2, GC-F

Feature Type

protein coding gene

Genetic Map

Chromosome X

62.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

ChrX:142081160-142196931 bp, - strand From VEGA annotation of GRCm38   115772 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37491  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: membrane-bound guanylate cyclase
Gene Tree: Gucy2f

Human homologs

Human Homolog		GUCY2F, guanylate cyclase 2F, retinal
NCBI Gene ID		2986
neXtProt AC		NX_P51841
Human Synonyms		CYGF, GC-F, GUC2DL, GUC2F, RETGC-2, ROS-GC2
Human Chr (Location)		Xq22; chrX:108616135-108725285 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for a knock-out allele exhibit abnormal retinal rod electrophysiology.

 
Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	cGMP biosynthetic process, cyclic nucleotide biosynthetic process, ...
Component	integral to membrane, membrane
Function	ATP binding, GTP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (98)    Tissues (97)    Images (4)
Theiler Stages: 20, 22, 28

Assay Type	Results
RNA in situ	96
RT-PCR	2

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) cDNA(10) Primer pair(2)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000018739 (Evidence)
Ensembl Gene Model	ENSMUSG00000042282 (Evidence)
Entrez Gene	245650 (Evidence)
UniGene	208511
DFCI	TC1597504
DoTS	DT.91336144
NIA Mouse Gene Index	U039745
EC	4.6.1.2
Consensus CDS Project	CCDS30446.1
International Mouse Knockout Project Status	Gucy2f

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018739	VEGA Gene Model | MGI Sequence Detail	115772	C57BL/6J
transcript	OTTMUST00000045079	VEGA | MGI Sequence Detail	8122	Not Applicable
polypeptide	OTTMUSP00000020265	VEGA | MGI Sequence Detail	1108	Not Applicable

All sequences(17) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(427 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro	IPR018297	Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site
InterPro	IPR001828	Extracellular ligand-binding receptor
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
Protein Ontology	PR:000008354	retinal guanylyl cyclase 2

References

(Earliest) J:31346 Yang RB, et al., Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina. Genomics. 1996 Feb 1;31(3):367-72
(Latest) J:192199 Makino CL, et al., Enzymatic relay mechanism stimulates cyclic GMP synthesis in rod photoresponse: biochemical and physiological study in guanylyl cyclase activating protein 1 knockout mice. PLoS One. 2012;7(10):e47637
All references(35)

Other accession IDs

MGD-MRK-32159