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Gucy2f Gene Detail
Summary
  • Symbol
    Gucy2f
  • Name
    guanylate cyclase 2f
  • Synonyms
    GC2, GC-F
  • Feature Type
    protein coding gene
  • IDs
    MGI:105119
    NCBI Gene: 245650
  • Gene Overview
    MyGene.info: GUCY2F
Location & Maps
more
  • Sequence Map
    ChrX:142081160-142196931 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      115772 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    GUCY2F, guanylate cyclase 2F, retinal
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GUCY2F, guanylate cyclase 2F, retinal
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CYGF, GC-F, GUC2DL, GUC2F, RETGC-2, ROS-GC2
  • Links
    NCBI Gene ID: 2986
    neXtProt AC: NX_P51841

  • Chr Location
    Xq22; chrX:109372017-109482056 (-)  GRCh38.p2

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    1 images
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Targeted
    4
  • Incidental Mutations
    APF
Mice homozygous for a knock-out allele exhibit abnormal retinal rod electrophysiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018739 VEGA Gene Model | MGI Sequence Detail 115772 C57BL/6J ±  kb
transcript OTTMUST00000045079 VEGA | MGI Sequence Detail 8122 Not Applicable  
polypeptide OTTMUSP00000020265 VEGA | MGI Sequence Detail 1108 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    436 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000008354 retinal guanylyl cyclase 2
  • EC
  • InterPro Domains
    IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
    IPR018297 Adenylyl cyclase class-4/guanylyl cyclase, conserved site
    IPR029787 Nucleotide cyclase
    IPR028082 Periplasmic binding protein-like I
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR001828 Receptor, ligand binding region
    IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
Molecular
Reagents
less
  • All nucleic 12
    cDNA 10
    Primer pair 2

    Microarray probesets 1
Other
Accession IDs
less
MGD-MRK-32159
References
more
  • Summaries
    All 31
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:31346 Yang RB, et al., Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina. Genomics. 1996 Feb 1;31(3):367-72
  • Latest
    J:192199 Makino CL, et al., Enzymatic relay mechanism stimulates cyclic GMP synthesis in rod photoresponse: biochemical and physiological study in guanylyl cyclase activating protein 1 knockout mice. PLoS One. 2012;7(10):e47637

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory