About   Help   FAQ
Gucy2f
Gene Detail
Symbol

Name
ID
Gucy2f
guanylate cyclase 2f
MGI:105119
Synonyms
GC2, GC-F
Feature Type
protein coding gene
Genetic Map
Chromosome X
62.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:142081160-142196931 bp, - strand
From VEGA annotation of GRCm38

  115772 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37491  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: membrane-bound guanylate cyclase
Gene Tree: Gucy2f

Human
homologs
Human Homolog GUCY2F, guanylate cyclase 2F, retinal
NCBI Gene ID 2986
neXtProt AC  NX_P51841
Human Synonyms  CYGF, GC-F, GUC2DL, GUC2F, RETGC-2, ROS-GC2
Human Chr (Location)  Xq22; chrX:109372906-109482056 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit abnormal retinal rod electrophysiology.
 
Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Gucy2f interacts with 444 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cGMP biosynthetic process, cyclic nucleotide biosynthetic process, ...
Component integral component of membrane, membrane
Function ATP binding, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (98)    Tissues (97)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 96
RT-PCR 2
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(10) Primer pair(2)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000018739 (Evidence)
Ensembl Gene ModelENSMUSG00000042282 (Evidence)
Entrez Gene245650 (Evidence)
UniGene208511
DFCITC1597504
DoTSDT.91336144
NIA Mouse Gene IndexU039745
EC4.6.1.2
Consensus CDS ProjectCCDS30446.1
International Mouse Knockout Project StatusGucy2f
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018739 VEGA Gene Model | MGI Sequence Detail 115772 C57BL/6J ±  kb
transcript OTTMUST00000045079 VEGA | MGI Sequence Detail 8122 Not Applicable 
polypeptide OTTMUSP00000020265 VEGA | MGI Sequence Detail 1108 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(4) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(432 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro IPR018297 Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
Protein Ontology PR:000008354 retinal guanylyl cyclase 2
References
(Earliest) J:31346 Yang RB, et al., Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina. Genomics. 1996 Feb 1;31(3):367-72
(Latest) J:192199 Makino CL, et al., Enzymatic relay mechanism stimulates cyclic GMP synthesis in rod photoresponse: biochemical and physiological study in guanylyl cyclase activating protein 1 knockout mice. PLoS One. 2012;7(10):e47637
All references(34)
Other
accession IDs
MGD-MRK-32159

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory