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Ctf1 Gene Detail
Summary
  • Symbol
    Ctf1
  • Name
    cardiotrophin 1
  • Synonyms
    CT-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:105115
    NCBI Gene: 13019
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:127712736-127718192 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 69.69 cM, cytoband F3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    45 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105115
protein coding gene Chr7:127712702-127718192 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033049
protein coding gene Chr7:132083369-132088825 (+)
A/J MGP_AJ_G0033032
protein coding gene Chr7:128557070-128562547 (+)
AKR/J MGP_AKRJ_G0032964
protein coding gene Chr7:131880972-131886442 (+)
BALB/cJ MGP_BALBcJ_G0033033
protein coding gene Chr7:128208552-128214022 (+)
C3H/HeJ MGP_C3HHeJ_G0032747
protein coding gene Chr7:131781230-131786700 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033542
protein coding gene Chr7:137231994-137238253 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030515
protein coding gene Chr7:129754822-129760976 (+)
CAST/EiJ MGP_CASTEiJ_G0032076
protein coding gene Chr7:123574977-123580450 (+)
CBA/J MGP_CBAJ_G0032720
protein coding gene Chr7:141876958-141882414 (+)
DBA/2J MGP_DBA2J_G0032872
protein coding gene Chr7:126535726-126541182 (+)
FVB/NJ MGP_FVBNJ_G0032825
protein coding gene Chr7:126388444-126393900 (+)
LP/J MGP_LPJ_G0032966
protein coding gene Chr7:133560599-133566055 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032857
protein coding gene Chr7:142966861-142973848 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033562
protein coding gene Chr7:130867632-130873102 (+)
PWK/PhJ MGP_PWKPhJ_G0031783
protein coding gene Chr7:119549514-119554848 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031629
protein coding gene Chr7:117673459-117678870 (+)
WSB/EiJ MGP_WSBEiJ_G0032188
protein coding gene Chr7:131832859-131838315 (+)



Homology
more
  • Human Ortholog
    CTF1, cardiotrophin 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CTF1, cardiotrophin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CT1, CT-1
  • Links
    NCBI Gene ID: 1489
    neXtProt AC: NX_Q16619
    UniProt: Q16619

  • Chr Location
    16p11.2; chr16:30895824-30903560 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Ctf1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 1 allele in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show a significant reduction in grip strength and increased motoneuron cell death in the spinal cord and brainstem nuclei between embryonic day 14 and the first postnatal week.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042340 Ensembl Gene Model | MGI Sequence Detail 5457 C57BL/6J ±  kb
    transcript ENSMUST00000047393 Ensembl | MGI Sequence Detail 1352 Not Applicable  
    polypeptide ENSMUSP00000049161 Ensembl | MGI Sequence Detail 203 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 1
      cDNA 14
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-32155
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 5
      Phenotypes 13
    • Earliest
      J:22950 Pennica D, et al., Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy. Proc Natl Acad Sci U S A. 1995 Feb 14;92(4):1142-6
    • Latest
      J:266917 Bortolotti F, et al., In Vivo Functional Selection Identifies Cardiotrophin-1 as a Cardiac Engraftment Factor for Mesenchymal Stromal Cells. Circulation. 2017 Oct 17;136(16):1509-1524

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    03/19/2019
    MGI 6.13
    The Jackson Laboratory