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Ctf1
Gene Detail
Symbol

Name
ID
Ctf1
cardiotrophin 1
MGI:105115
Synonyms
CT-1
Feature Type
protein coding gene
Genetic Map
Chromosome 7
69.69 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:127712736-127718185 bp, + strand
From Ensembl annotation of GRCm38

  5450 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1016  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Ctf1

Human
homologs
Human Homolog CTF1, cardiotrophin 1
NCBI Gene ID 1489
neXtProt AC  NX_Q16619
Human Synonyms  CT1, CT-1
Human Chr (Location)  16p11.2; chr16:30896607-30903560 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
 
Mice homozygous for a knock-out allele show a significant reduction in grip strength and increased motoneuron cell death in the spinal cord and brainstem nuclei between embryonic day 14 and the first postnatal week.
 
Human Diseases Modeled Using Mouse Ctf1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Ctf1 interacts with 94 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (133)    Tissues (108)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 116
RNA in situ 7
Western blot 5
RT-PCR 2
RNase protection 3
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) Genomic(1) cDNA(12) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000042340 (Evidence)
Entrez Gene13019 (Evidence)
UniGene389954
DFCITC1671043, TC1583788
NIA Mouse Gene IndexU008812
Consensus CDS ProjectCCDS21875.1
International Mouse Knockout Project StatusCtf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042340 Ensembl Gene Model | MGI Sequence Detail 5450 C57BL/6J ±  kb
transcript ENSMUST00000047393 Ensembl | MGI Sequence Detail 1345 Not Applicable 
polypeptide ENSMUSP00000049161 Ensembl | MGI Sequence Detail 203 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(44 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012351 Four-helical cytokine, core
InterPro IPR009079 Four-helical cytokine-like, core
InterPro IPR010681 Plethodontid receptivity factor PRF
Protein Ontology PR:000006003 cardiotrophin-1
References
(Earliest) J:22950 Pennica D, et al., Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy. Proc Natl Acad Sci U S A. 1995 Feb 14;92(4):1142-6
(Latest) J:196408 Jimenez-Gonzalez M, et al., Cardiotrophin 1 protects beta cells from apoptosis and prevents streptozotocin-induced diabetes in a mouse model. Diabetologia. 2013 Apr;56(4):838-46
All references(45)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-32155

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory