About   Help   FAQ
Ctf1
Gene Detail
 Symbol
Name
ID
Ctf1
cardiotrophin 1
MGI:105115
Synonyms CT-1
Feature Type protein coding gene
Genetic Map
Chromosome 7
69.69 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:127712736-127718185 bp, + strand
From NCBI annotation of GRCm38

  5450 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1016  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Ctf1

Human
homologs
Human Homolog CTF1, cardiotrophin 1
NCBI Gene ID 1489
neXtProt AC  NX_Q16619
Human Synonyms  CT1, CT-1
Human Chr (Location)  16p11.2; chr16:30896607-30903560 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
 
Mice homozygous for a knock-out allele show a significant reduction in grip strength and increased motoneuron cell death in the spinal cord and brainstem nuclei between embryonic day 14 and the first postnatal week.
 
Human Diseases Modeled Using Mouse Ctf1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Ctf1 interacts with 94 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process leukemia inhibitory factor signaling pathway, nervous system development, ...
Component extracellular region, extracellular space
Function cytokine activity, leukemia inhibitory factor receptor binding
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (133)    Tissues (107)    Images (15)
Theiler Stages: 13, 15, 17, 18, 19, 21, 22, 23, 28
Assay TypeResults
Immunohistochemistry 115
RNA in situ 7
Western blot 5
RT-PCR 2
RNase protection 3
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) Genomic(1) cDNA(12) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000042340 (Evidence)
Entrez Gene13019 (Evidence)
UniGene389954
DFCITC1583788, TC1671043
NIA Mouse Gene IndexU008812
Consensus CDS ProjectCCDS21875.1
International Mouse Knockout Project StatusCtf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13019 NCBI Gene Model | MGI Sequence Detail 5450 C57BL/6J ±  kb
transcript NM_001301282 RefSeq | MGI Sequence Detail 1403 C57BL/6 
polypeptide Q60753 UniProt | EBI | MGI Sequence Detail 203 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(8) UniProt(2)
Polymorphisms SNPs within 2kb(44 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012351 Four-helical cytokine, core
InterPro IPR009079 Four-helical cytokine-like, core
InterPro IPR010681 Plethodontid receptivity factor PRF
Protein Ontology PR:000006003 cardiotrophin-1
Graphical View of Protein Domain Structure
References (Earliest) J:22950 Pennica D, et al., Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy. Proc Natl Acad Sci U S A. 1995 Feb 14;92(4):1142-6
(Latest) J:196408 Jimenez-Gonzalez M, et al., Cardiotrophin 1 protects beta cells from apoptosis and prevents streptozotocin-induced diabetes in a mouse model. Diabetologia. 2013 Apr;56(4):838-46
All references(45)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-32155

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory