Ctf1
Gene Detail

Symbol Name ID

Ctf1 cardiotrophin 1 MGI:105115

Synonyms

CT-1

Feature Type

protein coding gene

Genetic Map

Chromosome 7

69.69 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:127712736-127718185 bp, + strand From NCBI annotation of GRCm38   5450 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Ctf1 ± 2 cM)

Gene Tree: Ctf1

Human ortholog

CTF1 cardiotrophin 1 NCBI Gene ID 1489
Human Synonyms: CT1, CT-1
Human Chr16:30907928-30914881 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(5) : Targeted(3) Gene trapped(2)
 

Mice homozygous for a knock-out allele show a significant reduction in grip strength and increased motoneuron cell death in the spinal cord and brainstem nuclei between embryonic day 14 and the first postnatal week.

 
Human Diseases Modeled Using Mouse Ctf1 (2)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	leukemia inhibitory factor signaling pathway, nervous system development, ...
Component	extracellular region, extracellular space
Function	cytokine activity, leukemia inhibitory factor receptor binding

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (133)    Tissues (107)    Images (15)
Theiler Stages: 13, 15, 17, 18, 19, 21, 22, 23, 28

Assay Type	Results
Immunohistochemistry	116
RNA in situ	7
Western blot	5
RT-PCR	2
RNase protection	3

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) Genomic(1) cDNA(12) Primer pair(2)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000042340 (Evidence)
Entrez Gene	13019 (Evidence)
UniGene	389954
DFCI	TC1583788
NIA Mouse Gene Index	U008812
Consensus CDS Project	CCDS21875.1
International Mouse Knockout Project Status	Ctf1

Sequences

Length	Strain/Species
genomic	13019	NCBI Gene Model | MGI Sequence Detail	5450	C57BL/6J
transcript	NM_007795	RefSeq | MGI Sequence Detail	1345	Not Specified
polypeptide	Q60753	UniProt | EBI | MGI Sequence Detail	203	Not Applicable

All sequences(13) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(19 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012351	Four-helical cytokine, core
InterPro	IPR009079	Four-helical cytokine-like, core
InterPro	IPR010681	Plethodontid receptivity factor PRF
Protein Ontology	PR:000006003	cardiotrophin-1

Graphical View of Protein Domain Structure

References

(Earliest) J:22950 Pennica D, et al., Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy. Proc Natl Acad Sci U S A. 1995 Feb 14;92(4):1142-6
(Latest) J:179108 Lopez-Andres N, et al., A role for cardiotrophin-1 in myocardial remodeling induced by aldosterone. Am J Physiol Heart Circ Physiol. 2011 Dec;301(6):H2372-82
All references(44)

Other accession IDs

MGD-MRK-32155