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Ctf1 Gene Detail
Summary
  • Symbol
    Ctf1
  • Name
    cardiotrophin 1
  • Synonyms
    CT-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:105115
    NCBI Gene: 13019
Location & Maps
more
  • Sequence Map
    Chr7:127712736-127718192 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5457 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 69.69 cM, cytoband F3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CTF1, cardiotrophin 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CTF1, cardiotrophin 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CT1, CT-1
  • Links
    NCBI Gene ID: 1489
    neXtProt AC: NX_Q16619

  • Chr Location
    16p11.2; chr16:30895828-30903560 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Ctf1 mouse models

Human Disease Mouse Models
       Diabetes Mellitus, Noninsulin-Dependent; NIDDM   OMIM: 125853 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 1 allele in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Gene trapped
    2
  • Targeted
    5
Mice homozygous for a knock-out allele show a significant reduction in grip strength and increased motoneuron cell death in the spinal cord and brainstem nuclei between embryonic day 14 and the first postnatal week.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000058629 VEGA Gene Model | MGI Sequence Detail 5457 C57BL/6J ±  kb
transcript OTTMUST00000143966 VEGA | MGI Sequence Detail 1352 Not Applicable  
polypeptide OTTMUSP00000075054 VEGA | MGI Sequence Detail 203 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    45 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000006003 cardiotrophin-1
  • InterPro Domains
    IPR012351 Four-helical cytokine, core
    IPR009079 Four-helical cytokine-like, core
    IPR010681 Plethodontid receptivity factor PRF
Molecular
Reagents
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  • All nucleic 15
    Genomic 1
    cDNA 12
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-32155
References
more
  • Summaries
    All 43
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:22950 Pennica D, et al., Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy. Proc Natl Acad Sci U S A. 1995 Feb 14;92(4):1142-6
  • Latest
    J:196408 Jimenez-Gonzalez M, et al., Cardiotrophin 1 protects beta cells from apoptosis and prevents streptozotocin-induced diabetes in a mouse model. Diabetologia. 2013 Apr;56(4):838-46

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory