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Hpx
Gene Detail
 Symbol
Name
ID
Hpx
hemopexin
MGI:105112
Synonyms Hpxn, hx
Feature Type protein coding gene
Genetic Map
Chromosome 7
55.91 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:105591613-105600116 bp, - strand
From Ensembl annotation of GRCm38

  8504 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:511  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: hemopexin
Gene Tree: Hpx

Human
homologs
Human Homolog HPX, hemopexin
NCBI Gene ID 3263
neXtProt AC  NX_P02790
Human Synonyms  HX
Human Chr (Location)  11p15.5-p15.4; chr11:6431038-6441024 (-)  GRCh38
Alleles
and
phenotypes
All alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display an essentially normal phenotype. However, they have increased susceptiblity to induced hemolytic stress.
 
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process heme metabolic process, hemoglobin metabolic process, ...
Component blood microparticle, extracellular region, ...
Function heme binding, metal ion binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (29)    Tissues (6)    Images (23)
Theiler Stages: 23, 26, 28
Assay TypeResults
RNA in situ 25
Northern blot 2
RT-PCR 2
cDNA source data(421)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(423) cDNA(421) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000030895 (Evidence)
Entrez Gene15458 (Evidence)
UniGene3485
DFCITC1571847, TC1777085
DoTSDT.110982377, DT.496141, DT.94250116
NIA Mouse Gene IndexU029039
Consensus CDS ProjectCCDS21654.1
International Mouse Knockout Project StatusHpx
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030895 Ensembl Gene Model | MGI Sequence Detail 8504 C57BL/6J ±  kb
transcript ENSMUST00000033185 Ensembl | MGI Sequence Detail 1478 Not Applicable 
polypeptide ENSMUSP00000033185 Ensembl | MGI Sequence Detail 460 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(28 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016358 Hemopexin, chordata
InterPro IPR018486 Hemopexin, conserved site
InterPro IPR000585 Hemopexin-like domain
InterPro IPR018487 Hemopexin-like repeats
Protein Ontology PR:000008743 hemopexin
References (Earliest) J:31175 Tolosano E, et al., Specific expression in brain and liver driven by the hemopexin promoter in transgenic mice. Biochem Biophys Res Commun. 1996 Jan 26;218(3):694-703
(Latest) J:210419 Vinchi F, et al., Hemopexin therapy improves cardiovascular function by preventing heme-induced endothelial toxicity in mouse models of hemolytic diseases. Circulation. 2013 Mar 26;127(12):1317-29
All references(41)
Other
accession IDs
MGD-MRK-32152

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory