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Pcolce
Gene Detail
 Symbol
Name
ID
Pcolce
procollagen C-endopeptidase enhancer protein
MGI:105099
Synonyms Astt2, Astt-2
Feature Type protein coding gene
Genetic Map
Chromosome 5
76.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr5:137605103-137613784 bp, - strand
From VEGA annotation of GRCm38

  8682 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1946  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Gene Tree: Pcolce

Human
homologs
Human Homolog PCOLCE, procollagen C-endopeptidase enhancer
NCBI Gene ID 5118
neXtProt AC  NX_Q15113
Human Synonyms  PCPE, PCPE1, PCPE-1
Human Chr (Location)  7q22; chr7:100602259-100608175 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(37) : Gene trapped(34) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in thickened cortical and trabecular bone and abnormal collagen fibrils in both mineralized and nonmineralized tissues.
 
Interactions
Pcolce interacts with 23 markers (Mir92-1, Mir149, Mir154, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process positive regulation of peptidase activity, proteolysis
Component collagen trimer, extracellular matrix, ...
Function collagen binding, heparin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (8)    Tissues (8)   
Theiler Stages: 10, 11, 13, 15, 18, 23, 25
Assay TypeResults
RNA in situ 4
Northern blot 4
cDNA source data(142)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(143) cDNA(142) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021947 (Evidence)
Ensembl Gene ModelENSMUSG00000029718 (Evidence)
Entrez Gene18542 (Evidence)
UniGene262345
DFCITC1572584
DoTSDT.101224155, DT.535693
Consensus CDS ProjectCCDS39334.1
International Mouse Knockout Project StatusPcolce
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021947 VEGA Gene Model | MGI Sequence Detail 8682 C57BL/6J ±  kb
transcript OTTMUST00000052097 VEGA | MGI Sequence Detail 1585 Not Applicable 
polypeptide OTTMUSP00000024636 VEGA | MGI Sequence Detail 493 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(4) UniProt(8)
Polymorphisms RFLP(1) : SNPs within 2kb(62 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000859 CUB domain
InterPro IPR001134 Netrin domain
InterPro IPR018933 Netrin module, non-TIMP type
InterPro IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Protein Ontology PR:000012427 procollagen C-endopeptidase enhancer 1
References (Earliest) J:10879 Rhyner TA, et al., Isolation of cDNAs from a mouse astroglial cell line by a subtracted cDNA library. J Neurosci Res. 1990 Oct;27(2):144-52
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(44)
Other
accession IDs
MGD-MRK-1436, MGD-MRK-1439, MGD-MRK-32139, MGI:88092

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory