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Efnb2
Gene Detail
Symbol

Name
ID
Efnb2
ephrin B2
MGI:105097
Synonyms
ELF-2, Epl5, Eplg5, Htk-L, Lerk5, LERK-5, NLERK-1
Feature Type
protein coding gene
Genetic Map
Chromosome 8
3.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:8617434-8660773 bp, - strand
From VEGA annotation of GRCm38

  43340 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3019  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 3 zebrafish

HCOP human homology predictions: EFNB2
Protein SuperFamily: Ephrin-B
Gene Tree: Efnb2

Human
homologs
EFNB2, ephrin-B2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1948
neXtProt AC: NX_P52799

Human Synonyms: EPLG5, Htk-L, HTKL, LERK5

Human Chr (Location): 13q33; chr13:106489731-106535040 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(2) Targeted(22)
Incidental mutations (data from APF , CvDC )
 
Homozygotes for targeted null mutations exhibit defects in angiogenesis of both arteries and veins and die by embryonic day 11.5.
 
Phenotype Images(1)
Interactions
Efnb2 interacts with 416 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process angiogenesis, axon guidance, ...
Component focal adhesion, integral component of membrane, ...
Function ephrin receptor binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (164 records)
Data Summary: Results (343)    Tissues (156)    Images (88)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 11
RNA in situ 275
In situ reporter (knock in) 36
RT-PCR 21
cDNA source data(84)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA EFNB2 ; Xenbase efnb2 ; ZFIN efnb2a    NEW 
Molecular
reagents
All nucleic(100) cDNA(87) Primer pair(7) Other(6)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000022160 (Evidence)
Ensembl Gene Model ENSMUSG00000001300 (Evidence)
Entrez Gene 13642 (Evidence)
UniGene 209813
DFCI TC1604337, TC1582913, TC1628729
DoTS DT.491395, DT.101735174
NIA Mouse Gene Index U029567
PDB 1KGY, 1IKO
Consensus CDS Project CCDS22090.1
International Mouse Phenotyping Consortium Status Efnb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022160 VEGA Gene Model | MGI Sequence Detail 43340 C57BL/6J ±  kb
transcript OTTMUST00000052622 VEGA | MGI Sequence Detail 4324 Not Applicable 
polypeptide OTTMUSP00000024973 VEGA | MGI Sequence Detail 336 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(6) UniProt(4)
Polymorphisms
RFLP(2) : SNPs within 2kb(172 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008972 Cupredoxin
InterPro IPR001799 Ephrin
InterPro IPR019765 Ephrin, conserved site
Protein Ontology PR:000006922 ephrin-B2
References
(Earliest) J:45123 Bonaldo MF, et al., Selection of cDNAs using chromosome-specific genomic clones: application to human chromosome 13. Hum Mol Genet. 1994 Sep;3(9):1663-73
(Latest) J:221868 Salvucci O, et al., EphrinB2 controls vessel pruning through STAT1-JNK3 signalling. Nat Commun. 2015;6:6576
All references(251)
Other
accession IDs
MGD-MRK-32137

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory