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Efnb2 Gene Detail
Summary
  • Symbol
    Efnb2
  • Name
    ephrin B2
  • Synonyms
    ELF-2, Epl5, Eplg5, Htk-L, Lerk5, LERK-5, NLERK-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:105097
    NCBI Gene: 13642
  • Gene Overview
    MyGene.info: EFNB2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:8617434-8661242 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 3.42 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    172 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105097
protein coding gene Chr8:8617235-8661260 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033341
protein coding gene Chr8:5690612-5733731 (-)
A/J MGP_AJ_G0033321
protein coding gene Chr8:5505824-5549059 (-)
AKR/J MGP_AKRJ_G0033253
protein coding gene Chr8:5686204-5729736 (-)
BALB/cJ MGP_BALBcJ_G0033322
protein coding gene Chr8:5639724-5684692 (-)
C3H/HeJ MGP_C3HHeJ_G0033036
protein coding gene Chr8:5840381-5884824 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033834
protein coding gene Chr8:5962494-6006662 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030805
protein coding gene Chr8:5097626-5141090 (-)
CAST/EiJ MGP_CASTEiJ_G0032358
protein coding gene Chr8:5505220-5550842 (-)
CBA/J MGP_CBAJ_G0033009
protein coding gene Chr8:6210411-6265324 (-)
DBA/2J MGP_DBA2J_G0033162
protein coding gene Chr8:5515629-5559275 (-)
FVB/NJ MGP_FVBNJ_G0033110
protein coding gene Chr8:5457460-5501796 (-)
LP/J MGP_LPJ_G0033256
protein coding gene Chr8:5598317-5641461 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033145
protein coding gene Chr8:6646169-6689393 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033851
protein coding gene Chr8:5678932-5722102 (-)
PWK/PhJ MGP_PWKPhJ_G0032071
protein coding gene Chr8:5447081-5490699 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031913
protein coding gene Chr8:5570510-5613766 (-)
WSB/EiJ MGP_WSBEiJ_G0032474
protein coding gene Chr8:5734058-5780018 (-)



Homology
more
  • Human Ortholog
    EFNB2, ephrin B2
  • Vertebrate Orthologs
    12
  • Human Ortholog
    EFNB2, ephrin B2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EPLG5, Htk-L, HTKL, LERK5
  • Links
    NCBI Gene ID: 1948
    neXtProt AC: NX_P52799
    UniProt: P52799

  • Chr Location
    13q33.3; chr13:106489731-106535040 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3019
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;3 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: EFNB2
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    99 phenotypes from 16 alleles in 16 genetic backgrounds
    31 phenotypes from multigenic genotypes
    1 images
    109 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit defects in angiogenesis of both arteries and veins and die by embryonic day 11.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001300 Ensembl Gene Model | MGI Sequence Detail 43809 C57BL/6J ±  kb
    transcript ENSMUST00000001319 Ensembl | MGI Sequence Detail 4793 Not Applicable  
    polypeptide ENSMUSP00000001319 Ensembl | MGI Sequence Detail 336 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 108
      cDNA 91
      Primer pair 7
      Other 10

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-32137
    References
    more
    • Summaries
      All 309
      Developmental Gene Expression 192
      Gene Ontology 20
      Phenotypes 109
    • Earliest
      J:45123 Bonaldo MF, et al., Selection of cDNAs using chromosome-specific genomic clones: application to human chromosome 13. Hum Mol Genet. 1994 Sep;3(9):1663-73
    • Latest
      J:264380 Artap S, et al., Endocardial Hippo signaling regulates myocardial growth and cardiogenesis. Dev Biol. 2018 Aug 1;440(1):22-30

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory