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Efnb2
Gene Detail
 Symbol
Name
ID
Efnb2
ephrin B2
MGI:105097
Synonyms ELF-2, Epl5, Eplg5, Htk-L, Lerk5, LERK-5, NLERK-1
Feature Type protein coding gene
Genetic Map
Chromosome 8
3.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:8617434-8660773 bp, - strand
From VEGA annotation of GRCm38

  43340 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3019  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 3 zebrafish

Protein SuperFamily: Ephrin-B
Gene Tree: Efnb2

Human
homologs
Human Homolog EFNB2, ephrin-B2
NCBI Gene ID 1948
neXtProt AC  NX_P52799
Human Synonyms  EPLG5, Htk-L, HTKL, LERK5
Human Chr (Location)  13q33; chr13:106489731-106535040 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(2) Targeted(22)
Incidental mutations (data from APF )
 
Homozygotes for targeted null mutations exhibit defects in angiogenesis of both arteries and veins and die by embryonic day 11.5.
 
Phenotype Images(1)
Interactions
Efnb2 interacts with 416 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process angiogenesis, axon guidance, ...
Component integral component of membrane, membrane, ...
Function ephrin receptor binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (151 records)
Data Summary: Results (335)    Tissues (147)    Images (84)
Theiler Stages: 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 11
RNA in situ 275
In situ reporter (knock in) 27
RT-PCR 21
cDNA source data(84)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(100) cDNA(87) Primer pair(7) Other(6)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000022160 (Evidence)
Ensembl Gene ModelENSMUSG00000001300 (Evidence)
Entrez Gene13642 (Evidence)
UniGene209813
DFCITC1582913, TC1604337, TC1628729
DoTSDT.101735174, DT.491395
NIA Mouse Gene IndexU029567
PDB1IKO, 1KGY
Consensus CDS ProjectCCDS22090.1
International Mouse Knockout Project StatusEfnb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022160 VEGA Gene Model | MGI Sequence Detail 43340 C57BL/6J ±  kb
transcript OTTMUST00000052622 VEGA | MGI Sequence Detail 4324 Not Applicable 
polypeptide OTTMUSP00000024973 VEGA | MGI Sequence Detail 336 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(4) UniProt(4)
Polymorphisms RFLP(2) : SNPs within 2kb(172 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008972 Cupredoxin
InterPro IPR001799 Ephrin
InterPro IPR019765 Ephrin, conserved site
Protein Ontology PR:000006922 ephrin-B2
References (Earliest) J:45123 Bonaldo MF, et al., Selection of cDNAs using chromosome-specific genomic clones: application to human chromosome 13. Hum Mol Genet. 1994 Sep;3(9):1663-73
(Latest) J:208418 Lindskog H, et al., Molecular identification of venous progenitors in the dorsal aorta reveals an aortic origin for the cardinal vein in mammals. Development. 2014 Mar;141(5):1120-8
All references(234)
Other
accession IDs
MGD-MRK-32137

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory