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Pgf Gene Detail
Summary
  • Symbol
    Pgf
  • Name
    placental growth factor
  • Synonyms
    PIGF, placenta growth factor, PLGF
  • Feature Type
    protein coding gene
  • IDs
    MGI:105095
    NCBI Gene: 18654
  • Gene Overview
    MyGene.info: PGF
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:85166637-85177785 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 39.58 cM, cytoband D
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    81 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105095
protein coding gene Chr12:85166635-85177790 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019954
protein coding gene Chr12:85931850-85941485 (-)
A/J MGP_AJ_G0019911
protein coding gene Chr12:82669473-82679909 (-)
AKR/J MGP_AKRJ_G0019887
protein coding gene Chr12:84904782-84915577 (-)
BALB/cJ MGP_BALBcJ_G0019891
protein coding gene Chr12:83013818-83023473 (-)
C3H/HeJ MGP_C3HHeJ_G0019697
protein coding gene Chr12:85379987-85390793 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020342
protein coding gene Chr12:88406881-88416442 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017960
protein coding gene Chr12:79555688-79565914 (-)
CAST/EiJ MGP_CASTEiJ_G0019246
protein coding gene Chr12:80353259-80363559 (-)
CBA/J MGP_CBAJ_G0019668
protein coding gene Chr12:91798724-91808288 (-)
DBA/2J MGP_DBA2J_G0019783
protein coding gene Chr12:82188016-82197568 (-)
FVB/NJ MGP_FVBNJ_G0019769
protein coding gene Chr12:81146773-81157579 (-)
LP/J MGP_LPJ_G0019855
protein coding gene Chr12:85804792-85815589 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019808
protein coding gene Chr12:94672134-94682470 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020376
protein coding gene Chr12:84512943-84523283 (-)
PWK/PhJ MGP_PWKPhJ_G0019010
protein coding gene Chr12:76680190-76690617 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018805
protein coding gene Chr12:78995749-79005884 (-)
WSB/EiJ MGP_WSBEiJ_G0019298
protein coding gene Chr12:85231545-85241828 (-)



Homology
more
  • Human Ortholog
    PGF, placental growth factor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PGF, placental growth factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    D12S1900, PGFL, PIGF, PLGF, PlGF-2, SHGC-10760
  • Links
    NCBI Gene ID: 5228
    neXtProt AC: NX_P49763
    UniProt: P49763

  • Chr Location
    14q24.3; chr14:74941830-74955764 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1978
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 macaque, rhesus
  • HCOP
    human homology predictions: PGF
  • Gene Tree
    Pgf
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 5 genetic backgrounds
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display subtle abnormalities related to reduced angiogenesis. Body weight at birth is reduced and body fat is significantly reduced.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18654 NCBI Gene Model | MGI Sequence Detail 11149 C57BL/6J ±  kb
    transcript NM_008827 RefSeq | MGI Sequence Detail 1599 C57BL/6  
    polypeptide P49764 UniProt | EBI | MGI Sequence Detail 158 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 59
      Genomic 4
      cDNA 51
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-32135, MGI:2144912
    References
    more
    • Summaries
      All 92
      Developmental Gene Expression 20
      Gene Ontology 9
      Phenotypes 36
    • Earliest
      J:30836 DiPalma T, et al., The placenta growth factor gene of the mouse. Mamm Genome. 1996 Jan;7(1):6-12
    • Latest
      J:265152 Hou HH, et al., MMP-12 activates protease-activated receptor-1, upregulates placenta growth factor, and leads to pulmonary emphysema. Am J Physiol Lung Cell Mol Physiol. 2018 Sep 1;315(3):L432-L442

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory