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Pgf Gene Detail
Summary
  • Symbol
    Pgf
  • Name
    placental growth factor
  • Synonyms
    PIGF, placenta growth factor, PLGF
  • Feature Type
    protein coding gene
  • IDs
    MGI:105095
    NCBI Gene: 18654
  • Gene Overview
    MyGene.info: PGF
Location & Maps
more
  • Sequence Map
    Chr12:85166639-85177296 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10658 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PGF, placental growth factor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PGF, placental growth factor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    D12S1900, PGFL, PLGF, PlGF-2, SHGC-10760
  • Links
    NCBI Gene ID: 5228
    neXtProt AC: NX_P49763

  • Chr Location
    14q24.3; chr14:74941830-74955764 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1978
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish
  • HCOP
    human homology predictions: PGF
  • Gene Tree
    Pgf
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 2 alleles in 5 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Targeted
    5
  • Transgenic
    1
  • Genomic Mutations
    1 involving Pgf
  • Incidental Mutations
Mice homozygous for disruptions in this gene display subtle abnormalities related to reduced angiogenesis. Body weight at birth is reduced and body fat is significantly reduced.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000004791 Ensembl Gene Model | MGI Sequence Detail 10658 C57BL/6J ±  kb
transcript ENSMUST00000004913 Ensembl | MGI Sequence Detail 1582 Not Applicable  
polypeptide ENSMUSP00000004913 Ensembl | MGI Sequence Detail 158 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    81 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000012605 placenta growth factor
  • InterPro Domains
    IPR029034 Cystine-knot cytokine
    IPR000072 PDGF/VEGF domain
    IPR023581 Platelet-derived growth factor, conserved site
Molecular
Reagents
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  • All nucleic 58
    Genomic 4
    cDNA 50
    Primer pair 4

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-32135, MGI:2144912
References
more
  • Summaries
    All 68
    Developmental Gene Expression 17
    Gene Ontology 6
    Phenotypes 29
  • Earliest
    J:30836 DiPalma T, et al., The placenta growth factor gene of the mouse. Mamm Genome. 1996 Jan;7(1):6-12
  • Latest
    J:216405 Oladipupo SS, et al., Endothelial cell FGF signaling is required for injury response but not for vascular homeostasis. Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13379-84

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory