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Adcyap1
Gene Detail
Symbol

Name
ID
Adcyap1
adenylate cyclase activating polypeptide 1
MGI:105094
Synonyms
PACAP
Feature Type
protein coding gene
Genetic Map
Chromosome 17
60.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:93199422-93205485 bp, + strand
From Ensembl annotation of GRCm38

  6064 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:869  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: ADCYAP1
Protein SuperFamily: glucagon
Gene Tree: Adcyap1

Human
homologs
ADCYAP1, adenylate cyclase activating polypeptide 1 (pituitary)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 116
neXtProt AC: NX_P18509

Human Synonyms: PACAP

Human Chr (Location): 18p11; chr18:904345-912172 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit high postnatal mortality, impaired thermoregulation, and loss of white fat. Survivors show ketosis, microvesicular fat accumulation, elevated serum lipids, and behavioral abnormalities.
 
Interactions
Adcyap1 interacts with 235 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (69 annotations)
Process activation of adenylate cyclase activity, ATP metabolic process, ...
Component cytosol, extracellular region, ...
Function hormone activity, neuropeptide hormone activity, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (363)    Tissues (140)    Images (45)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 352
RNase protection 11
cDNA source data(16)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase adcyap1 ; ZFIN adcyap1a    NEW 
Molecular
reagents
All nucleic(22) Genomic(2) cDNA(18) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000024256 (Evidence)
Entrez Gene 11516 (Evidence)
UniGene 3407
DFCI TC1580605
DoTS DT.94293722, DT.94130364, DT.524709
NIA Mouse Gene Index U018344
Consensus CDS Project CCDS29029.1
International Mouse Phenotyping Consortium Status Adcyap1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024256 Ensembl Gene Model | MGI Sequence Detail 6064 C57BL/6J ±  kb
transcript ENSMUST00000064775 Ensembl | MGI Sequence Detail 2088 Not Applicable 
polypeptide ENSMUSP00000067057 Ensembl | MGI Sequence Detail 175 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(8) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(29 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000532 Glucagon/GIP/secretin/VIP
Protein Ontology PR:000003761 pituitary adenylate cyclase-activating polypeptide
References
(Earliest) J:29992 Okazaki K, et al., Characterization of murine PACAP mRNA. Peptides. 1995;16(7):1295-9
(Latest) J:220523 Harris JA, et al., Anatomical characterization of Cre driver mice for neural circuit mapping and manipulation. Front Neural Circuits. 2014;8:76
All references(108)
Other
accession IDs
MGD-MRK-32134

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory