Adcyap1 MGI Mouse Gene Detail - MGI:105094 - adenylate cyclase activating polypeptide 1

Symbol

Adcyap1
Name

adenylate cyclase activating polypeptide 1
Synonyms

PACAP

Feature Type

protein coding gene
IDs

MGI:105094
NCBI Gene: 11516
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr17:93506448-93513967 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 60.67 cM
Mapping Data

1 experiment

SNPs within 2kb

33 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105094	protein coding gene	Chr17:93506445-93513967 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024117	protein coding gene	Chr17:96912239-96918311 (+)
A/J	MGP_AJ_G0024077	protein coding gene	Chr17:93726801-93732871 (+)
AKR/J	MGP_AKRJ_G0024046	protein coding gene	Chr17:95272056-95278146 (+)
BALB/cJ	MGP_BALBcJ_G0024078	protein coding gene	Chr17:93573747-93579816 (+)
C3H/HeJ	MGP_C3HHeJ_G0023843	protein coding gene	Chr17:96206843-96212915 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024523	protein coding gene	Chr17:100239829-100245892 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021962	protein coding gene	Chr17:88550706-88556779 (+)
CAST/EiJ	MGP_CASTEiJ_G0023322	protein coding gene	Chr17:97158124-97164220 (+)
CBA/J	MGP_CBAJ_G0023817	protein coding gene	Chr17:104398966-104407200 (+)
DBA/2J	MGP_DBA2J_G0023945	protein coding gene	Chr17:92090040-92096124 (+)
FVB/NJ	MGP_FVBNJ_G0023911	protein coding gene	Chr17:91568053-91574109 (+)
LP/J	MGP_LPJ_G0024029	protein coding gene	Chr17:97631465-97637538 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023939	protein coding gene	Chr17:104818278-104824341 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024568	protein coding gene	Chr17:95846877-95852949 (+)
PWK/PhJ	MGP_PWKPhJ_G0023067	protein coding gene	Chr17:91831558-91837677 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022878	protein coding gene	Chr17:92670764-92676851 (+)
WSB/EiJ	MGP_WSBEiJ_G0023388	protein coding gene	Chr17:96787748-96793810 (+)

Human Ortholog

ADCYAP1, adenylate cyclase activating polypeptide 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ADCYAP1, adenylate cyclase activating polypeptide 1
Synonyms

PACAP
Links

HGNC:241

NCBI Gene ID: 116

neXtProt AC: NX_P18509

UniProt: P18509
Chr Location

18p11.32; chr18:904411-912172 (+) GRCh38

MGI Vertebrate Homology

Adcyap1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ADCYAP1
Gene Tree

Adcyap1

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Phenotype Summary

47 phenotypes from 4 alleles in 7 genetic backgrounds
134 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

2
Targeted

10
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygotes for targeted null mutations exhibit high postnatal mortality, impaired thermoregulation, and loss of white fat. Survivors show ketosis, microvesicular fat accumulation, elevated serum lipids, and behavioral abnormalities.

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All GO Annotations

84
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1113
Tissues

161
cDNA Data

18
Literature Summary

24

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ADCYAP1

Xenbase adcyap1

ZFIN adcyap1a

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All Sequences

63
RefSeq

20
UniProt

5
CCDS

CCDS29029.1

Ensembl

ENSMUSG00000024256 (Evidence)
NCBI Gene

11516

			Length	Strain/Species	Flank
genomic	11516	NCBI Gene Model \| MGI Sequence Detail	7520	C57BL/6J	± kb
transcript	NM_001409525	RefSeq \| MGI Sequence Detail	3480	C57BL/6
polypeptide	O70176	UniProt \| EBI \| MGI Sequence Detail	175	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000003761 pituitary adenylate cyclase-activating polypeptide

(term hierarchy)
InterPro Domains

IPR000532 Glucagon/GIP/secretin/VIP

IPR046963 VIP/GHRH-like

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All nucleic 24

Genomic 2

cDNA 20

Primer pair 1

Other 1

Microarray probesets 3

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MGD-MRK-32134

Summaries

All 213

Developmental Gene Expression 24

Gene Ontology 10

Phenotypes 134
Earliest

J:29992 Okazaki K, et al., Characterization of murine PACAP mRNA. Peptides. 1995;16(7):1295-9
Latest

J:344744 Sbei S, et al., PACAP activates MRGPRX2 on meningeal mast cells to drive migraine-like pain. Sci Rep. 2023 Jul 29;13(1):12302

TSS for Adcyap1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr146260	Chr17:93506436-93506461 (+)	1 bp
Tssr146261	Chr17:93506545-93506574 (+)	112 bp
Tssr146262	Chr17:93506590-93506601 (+)	148 bp
Tssr146263	Chr17:93506776-93506836 (+)	358 bp
Tssr146264	Chr17:93506935-93506946 (+)	493 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23