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Adcyap1
Gene Detail
 Symbol
Name
ID
Adcyap1
adenylate cyclase activating polypeptide 1
MGI:105094
Synonyms PACAP
Feature Type protein coding gene
Genetic Map
Chromosome 17
60.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:93199422-93205485 bp, + strand
From Ensembl annotation of GRCm38

  6064 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:869  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken

Protein SuperFamily: glucagon
Gene Tree: Adcyap1

Human
homologs
Human Homolog ADCYAP1, adenylate cyclase activating polypeptide 1 (pituitary)
NCBI Gene ID 116
neXtProt AC  NX_P18509
Human Synonyms  PACAP
Human Chr (Location)  18p11; chr18:904365-912172 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit high postnatal mortality, impaired thermoregulation, and loss of white fat. Survivors show ketosis, microvesicular fat accumulation, elevated serum lipids, and behavioral abnormalities.
 
Interactions
Adcyap1 interacts with 235 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (68 annotations)
Process activation of adenylate cyclase activity, ATP metabolic process, ...
Component cytosol, extracellular region, ...
Function hormone activity, neuropeptide hormone activity, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (363)    Tissues (139)    Images (45)
Theiler Stages: 15, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 352
RNase protection 11
cDNA source data(16)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(2) cDNA(18) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000024256 (Evidence)
Entrez Gene11516 (Evidence)
UniGene3407
DFCITC1580605
DoTSDT.524709, DT.94130364, DT.94293722
NIA Mouse Gene IndexU018344
Consensus CDS ProjectCCDS29029.1
International Mouse Knockout Project StatusAdcyap1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024256 Ensembl Gene Model | MGI Sequence Detail 6064 C57BL/6J ±  kb
transcript ENSMUST00000064775 Ensembl | MGI Sequence Detail 2088 Not Applicable 
polypeptide ENSMUSP00000067057 Ensembl | MGI Sequence Detail 175 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(8) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(29 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000532 Glucagon/GIP/secretin/VIP
Protein Ontology PR:000003761 pituitary adenylate cyclase-activating polypeptide
References (Earliest) J:29992 Okazaki K, et al., Characterization of murine PACAP mRNA. Peptides. 1995;16(7):1295-9
(Latest) J:207472 Krashes MJ, et al., An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger. Nature. 2014 Mar 13;507(7491):238-42
All references(106)
Other
accession IDs
MGD-MRK-32134

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory