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Cnn2 Gene Detail
Summary
  • Symbol
    Cnn2
  • Name
    calponin 2
  • Synonyms
    Calpo2, h2-calponin
  • Feature Type
    protein coding gene
  • IDs
    MGI:105093
    NCBI Gene: 12798
Location & Maps
more
  • Sequence Map
    Chr10:79988584-79996062 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7479 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CNN2, calponin 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CNN2, calponin 2
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 1265
    neXtProt AC: NX_Q99439

  • Chr Location
    19p13.3; chr19:1026275-1039068 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Targeted
    5
  • Genomic Mutations
    1 involving Cnn2
Mice homozygous for either a knock-out or a knock-down allele have reduced numbers of peripheral blood neutrophils and monocytes. Knock-out mice show increased macrophage proliferation, motility and phagocytosis, faster diapedesis of peripheral monocytesand neutrophils, and enhanced wound healing.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019132 VEGA Gene Model | MGI Sequence Detail 7479 C57BL/6J ±  kb
transcript OTTMUST00000045857 VEGA | MGI Sequence Detail 2460 Not Applicable  
polypeptide OTTMUSP00000020660 VEGA | MGI Sequence Detail 305 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    12 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 219
    Genomic 1
    cDNA 215
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-32133, MGI:2143461, MGI:2143578
References
more
  • Summaries
    All 37
    Developmental Gene Expression 8
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:30866 Strasser P, et al., Mammalian calponin. Identification and expression of genetic variants. FEBS Lett. 1993 Sep 6;330(1):13-8
  • Latest
    J:184582 Lopes M, et al., Msx1 is expressed in retina endothelial cells at artery branching sites. Biol Open. 2012;1(4):376-384

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory