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Cnn2
Gene Detail
Symbol

Name
ID
Cnn2
calponin 2
MGI:105093
Synonyms
Calpo2, h2-calponin
Feature Type
protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:79988584-79996062 bp, + strand
From VEGA annotation of GRCm38

  7479 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3215  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: calponin
Gene Tree: Cnn2

Human
homologs
Human Homolog CNN2, calponin 2
NCBI Gene ID 1265
neXtProt AC  NX_Q99439
Human Chr (Location)  19p13.3; chr19:1026299-1039065 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
 
Mice homozygous for either a knock-out or a knock-down allele have reduced numbers of peripheral blood neutrophils and monocytes. Knock-out mice show increased macrophage proliferation, motility and phagocytosis, faster diapedesis of peripheral monocytes and neutrophils, and enhanced wound healing.
 
Interactions
Cnn2 interacts with 163 markers (Mir15a, Mir16-1, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process actomyosin structure organization, cellular response to mechanical stimulus, ...
Component extracellular vesicular exosome, focal adhesion, ...
Function actin binding, calmodulin binding
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (56)    Tissues (41)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 54
RT-PCR 2
cDNA source data(215)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(219) Genomic(1) cDNA(215) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000019132 (Evidence)
Ensembl Gene ModelENSMUSG00000004665 (Evidence)
Entrez Gene12798 (Evidence)
UniGene157770
DFCITC1572725
DoTSDT.537186, DT.101401781, DT.101401783, DT.110628591, DT.110628786, DT.110629048, DT.110629576, DT.55237328
NIA Mouse Gene IndexU011733
Consensus CDS ProjectCCDS24003.1
International Mouse Knockout Project StatusCnn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019132 VEGA Gene Model | MGI Sequence Detail 7479 C57BL/6J ±  kb
transcript OTTMUST00000045857 VEGA | MGI Sequence Detail 2460 Not Applicable 
polypeptide OTTMUSP00000020660 VEGA | MGI Sequence Detail 305 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(12 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001997 Calponin
InterPro IPR001715 Calponin homology domain
InterPro IPR000557 Calponin repeat
InterPro IPR003096 Smooth muscle protein/calponin
Protein Ontology PR:000005641 calponin-2
References
(Earliest) J:30866 Strasser P, et al., Mammalian calponin. Identification and expression of genetic variants. FEBS Lett. 1993 Sep 6;330(1):13-8
(Latest) J:184582 Lopes M, et al., Msx1 is expressed in retina endothelial cells at artery branching sites. Biol Open. 2012;1(4):376-384
All references(42)
Other
accession IDs
MGD-MRK-32133, MGI:2143461, MGI:2143578

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory