Slc6a5
Gene Detail

Symbol Name ID

Slc6a5 solute carrier family 6 (neurotransmitter transporter, glycine), member 5 MGI:105090

Synonyms

Glyt2

Feature Type

protein coding gene

Genetic Map

Chromosome 7

31.71 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:49910299-49959493 bp, + strand From NCBI annotation of GRCm38   49195 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37901  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Slc6a5

Human homologs

Human Homolog		SLC6A5, solute carrier family 6 (neurotransmitter transporter, glycine), member 5
NCBI Gene ID		9152
neXtProt AC		NX_Q9Y345
Human Synonyms		GLYT2, GLYT-2, HKPX3, NET1
Human Chr (Location)		11p15.1; chr11:20620946-20676610 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SLC6A5

Alleles and phenotypes

All alleles(3) : Targeted(2) Spontaneous(1)
 

Homozygous mutant mice appear normal at birth but develop a complex neuromotor phenotype involving tremors, rigidity, and an impaired righting ability. Mutant mice die approximately 2 weeks after birth.

 
Human Diseases Modeled Using Mouse Slc6a5 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	glycine transport, neurotransmitter transport, ...
Component	integral to membrane, membrane
Function	glycine transmembrane transporter activity, neurotransmitter:sodium symporter activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (202)    Tissues (25)    Images (39)
Theiler Stages: 19, 20, 23

Assay Type	Results
RNA in situ	202

cDNA source data(8)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(10) cDNA(8) Primer pair(1) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000039728 (Evidence)
Entrez Gene	104245 (Evidence)
UniGene	207053
DFCI	TC1587291
DoTS	DT.101150091, DT.97343240
NIA Mouse Gene Index	U008132
Consensus CDS Project	CCDS21308.1
International Mouse Knockout Project Status	Slc6a5

Sequences

Length	Strain/Species
genomic	104245	NCBI Gene Model | MGI Sequence Detail	49195	C57BL/6J
transcript	NM_001146013	RefSeq | MGI Sequence Detail	2549	Not Specified
polypeptide	Q761V0	UniProt | EBI | MGI Sequence Detail	799	Not Applicable

All sequences(25) RefSeq(4) UniProt(3)

Polymorphisms

SNPs(378 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000175	Sodium:neurotransmitter symporter
Protein Ontology	PR:000015190	sodium- and chloride-dependent glycine transporter 2

Graphical View of Protein Domain Structure

References

(Earliest) J:22931 Jursky F, et al., Localization of glycine neurotransmitter transporter (GLYT2) reveals correlation with the distribution of glycine receptor. J Neurochem. 1995 Mar;64(3):1026-33
(Latest) J:184306 Bogdanik LP, et al., A MusD retrotransposon insertion in the mouse Slc6a5 gene causes alterations in neuromuscular junction maturation and behavioral phenotypes. PLoS One. 2012;7(1):e30217
All references(40)

Other accession IDs

MGD-MRK-32130