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Slc6a5
Gene Detail
Symbol

Name
ID
Slc6a5
solute carrier family 6 (neurotransmitter transporter, glycine), member 5
MGI:105090
Synonyms
Glyt2
Feature Type
protein coding gene
Genetic Map
Chromosome 7
31.71 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:49910146-49963856 bp, + strand
From Ensembl annotation of GRCm38

  53711 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37901  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: SLC6A5
Gene Tree: Slc6a5

Human
homologs
SLC6A5, solute carrier family 6 (neurotransmitter transporter), member 5
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 9152
neXtProt AC: NX_Q9Y345

Human Synonyms: GLYT2, GLYT-2, HKPX3, NET1

Human Chr (Location): 11p15.1; chr11:20599400-20659285 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SLC6A5

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice appear normal at birth but develop a complex neuromotor phenotype involving tremors, rigidity, and an impaired righting ability. Mutant mice die approximately 2 weeks after birth.
 
Human Diseases Modeled in Mice Using Slc6a5 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Slc6a5 interacts with 382 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process glycine import, glycine transport, ...
Component integral component of membrane, membrane, ...
Function glycine:sodium symporter activity, glycine transmembrane transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (224)    Tissues (47)    Images (40)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 224
cDNA source data(8)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: ZFIN slc6a5    NEW 
Molecular
reagents
All nucleic(10) cDNA(8) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000039728 (Evidence)
Entrez Gene 104245 (Evidence)
UniGene 207053
DFCI TC1587291
DoTS DT.97343240, DT.101150091
NIA Mouse Gene Index U008132
Consensus CDS Project CCDS21308.1
International Mouse Phenotyping Consortium Status Slc6a5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039728 Ensembl Gene Model | MGI Sequence Detail 53711 C57BL/6J ±  kb
transcript ENSMUST00000056442 Ensembl | MGI Sequence Detail 7065 Not Applicable 
polypeptide ENSMUSP00000058699 Ensembl | MGI Sequence Detail 791 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(16) UniProt(3)
Polymorphisms
SNPs within 2kb(537 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000175 Sodium:neurotransmitter symporter
Protein Ontology PR:000015190 sodium- and chloride-dependent glycine transporter 2
References
(Earliest) J:22931 Jursky F, et al., Localization of glycine neurotransmitter transporter (GLYT2) reveals correlation with the distribution of glycine receptor. J Neurochem. 1995 Mar;64(3):1026-33
(Latest) J:219115 Foster E, et al., Targeted Ablation, Silencing, and Activation Establish Glycinergic Dorsal Horn Neurons as Key Components of a Spinal Gate for Pain and Itch. Neuron. 2015 Mar 18;85(6):1289-1304
All references(46)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-32130

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory