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Slc6a5
Gene Detail
 Symbol
Name
ID
Slc6a5
solute carrier family 6 (neurotransmitter transporter, glycine), member 5
MGI:105090
Synonyms Glyt2
Feature Type protein coding gene
Genetic Map
Chromosome 7
31.71 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:49910299-49959493 bp, + strand
From NCBI annotation of GRCm38

  49195 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37901  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Slc6a5

Human
homologs
Human Homolog SLC6A5, solute carrier family 6 (neurotransmitter transporter), member 5
NCBI Gene ID 9152
neXtProt AC  NX_Q9Y345
Human Synonyms  GLYT2, GLYT-2, HKPX3, NET1
Human Chr (Location)  11p15.1; chr11:20599400-20655064 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SLC6A5
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice appear normal at birth but develop a complex neuromotor phenotype involving tremors, rigidity, and an impaired righting ability. Mutant mice die approximately 2 weeks after birth.
 
Human Diseases Modeled Using Mouse Slc6a5 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Slc6a5 interacts with 382 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process glycine import, glycine transport, ...
Component integral component of membrane, membrane, ...
Function glycine:sodium symporter activity, glycine transmembrane transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (224)    Tissues (47)    Images (40)
Theiler Stages: 19, 20, 23, 28
Assay TypeResults
RNA in situ 224
cDNA source data(8)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(8) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000039728 (Evidence)
Entrez Gene104245 (Evidence)
UniGene207053
DFCITC1587291
DoTSDT.101150091, DT.97343240
NIA Mouse Gene IndexU008132
Consensus CDS ProjectCCDS21308.1
International Mouse Knockout Project StatusSlc6a5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 104245 NCBI Gene Model | MGI Sequence Detail 49195 C57BL/6J ±  kb
transcript NM_001146013 RefSeq | MGI Sequence Detail 2549 Not Specified 
polypeptide Q761V0 UniProt | EBI | MGI Sequence Detail 799 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(14) UniProt(3)
Polymorphisms SNPs within 2kb(494 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000175 Sodium:neurotransmitter symporter
Protein Ontology PR:000015190 sodium- and chloride-dependent glycine transporter 2
Graphical View of Protein Domain Structure
References (Earliest) J:22931 Jursky F, et al., Localization of glycine neurotransmitter transporter (GLYT2) reveals correlation with the distribution of glycine receptor. J Neurochem. 1995 Mar;64(3):1026-33
(Latest) J:196947 Wildner H, et al., Genome-wide expression analysis of Ptf1a- and Ascl1-deficient mice reveals new markers for distinct dorsal horn interneuron populations contributing to nociceptive reflex plasticity. J Neurosci. 2013 Apr 24;33(17):7299-307
All references(46)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-32130

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory