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Slc6a5 Gene Detail
Summary
  • Symbol
    Slc6a5
  • Name
    solute carrier family 6 (neurotransmitter transporter, glycine), member 5
  • Synonyms
    Glyt2
  • Feature Type
    protein coding gene
  • IDs
    MGI:105090
    NCBI Gene: 104245
  • Gene Overview
    MyGene.info: SLC6A5
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:49910146-49963856 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 31.71 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    553 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105090
protein coding gene Chr7:49906971-49963864 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032301
protein coding gene Chr7:50596600-50656882 (+)
A/J MGP_AJ_G0032280
protein coding gene Chr7:49827801-49889131 (+)
AKR/J MGP_AKRJ_G0032216
protein coding gene Chr7:51028039-51082835 (+)
BALB/cJ MGP_BALBcJ_G0032292
protein coding gene Chr7:49498062-49558190 (+)
C3H/HeJ MGP_C3HHeJ_G0032005
protein coding gene Chr7:51393028-51450488 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032785
protein coding gene Chr7:52903000-52958364 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029791
protein coding gene Chr7:53002720-53055900 (+)
CAST/EiJ MGP_CASTEiJ_G0031333
protein coding gene Chr7:42810221-42865057 (+)
CBA/J MGP_CBAJ_G0031970
protein coding gene Chr7:54694651-54753260 (+)
DBA/2J MGP_DBA2J_G0032127
protein coding gene Chr7:49051623-49105333 (+)
FVB/NJ MGP_FVBNJ_G0032081
protein coding gene Chr7:48988832-49041962 (+)
LP/J MGP_LPJ_G0032208
protein coding gene Chr7:51536318-51593606 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032118
protein coding gene Chr7:53780450-53840756 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032802
protein coding gene Chr7:50003747-50062264 (+)
PWK/PhJ MGP_PWKPhJ_G0031053
protein coding gene Chr7:42393086-42450651 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030894
protein coding gene Chr7:38175602-38234472 (+)
WSB/EiJ MGP_WSBEiJ_G0031451
protein coding gene Chr7:50659066-50716319 (+)



Homology
more
  • Human Ortholog
    SLC6A5, solute carrier family 6 member 5
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SLC6A5, solute carrier family 6 member 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GLYT2, GLYT-2, HKPX3, NET1
  • Links
    NCBI Gene ID: 9152
    neXtProt AC: NX_Q9Y345
    UniProt: Q9Y345

  • Chr Location
    11p15.1; chr11:20599400-20659285 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 37901
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SLC6A5
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Slc6a5 mouse models; 1 with human SLC6A5 associations

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 4 alleles in 4 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice appear normal at birth but develop a complex neuromotor phenotype involving tremors, rigidity, and an impaired righting ability. Mutant mice die approximately 2 weeks after birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039728 Ensembl Gene Model | MGI Sequence Detail 53711 C57BL/6J ±  kb
    transcript ENSMUST00000207753 Ensembl | MGI Sequence Detail 6966 Not Applicable  
    polypeptide ENSMUSP00000146917 Ensembl | MGI Sequence Detail 791 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000015190 sodium- and chloride-dependent glycine transporter 2
    • InterPro Domains
      IPR000175 Sodium:neurotransmitter symporter
      IPR037272 Sodium:neurotransmitter symporter superfamily
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 9
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-32130
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 13
      Diseases 2
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:22931 Jursky F, et al., Localization of glycine neurotransmitter transporter (GLYT2) reveals correlation with the distribution of glycine receptor. J Neurochem. 1995 Mar;64(3):1026-33
    • Latest
      J:243154 Sunagawa M, et al., Distinct development of the glycinergic terminals in the ventral and dorsal horns of the mouse cervical spinal cord. Neuroscience. 2017 Feb 20;343:459-471

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory