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Pou2af1 Gene Detail
Summary
  • Symbol
    Pou2af1
  • Name
    POU domain, class 2, associating factor 1
  • Synonyms
    Bob1, Bob-1, BOB.1, OBF-1, OBF.1, OCAB, OCA-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:105086
    NCBI Gene: 18985
  • Gene Overview
    MyGene.info: POU2AF1
Location & Maps
more
  • Sequence Map
    Chr9:51213690-51240079 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      26390 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 27.95 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    POU2AF1, POU class 2 associating factor 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    POU2AF1, POU class 2 associating factor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BOB1, OBF1, OBF-1, OCAB
  • Links
    NCBI Gene ID: 5450
    neXtProt AC: NX_Q16633

  • Chr Location
    11q23.1; chr11:111352251-111379432 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 3 alleles in 4 genetic backgrounds
    21 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Targeted
    5
Homozygotes for targeted null mutations exhibit reduced numbers of mature B cells, absence of germinal centers, and low serum levels of non-IgM immunoglobulins.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18985 NCBI Gene Model | MGI Sequence Detail 26390 C57BL/6J ±  kb
transcript NM_011136 RefSeq | MGI Sequence Detail 2566 C57BL/6  
polypeptide Q64693 UniProt | EBI | MGI Sequence Detail 256 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    282 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000013034 POU domain class 2-associating factor 1
  • InterPro Domains
    IPR015389 POU, class 2, associating factor 1
Molecular
Reagents
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  • All nucleic 40
    Genomic 2
    cDNA 35
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-32126
References
more
  • Summaries
    All 68
    Developmental Gene Expression 9
    Gene Ontology 4
    Phenotypes 35
  • Earliest
    J:30126 Pfisterer P, et al., Functional characterization of the murine homolog of the B cell-specific coactivator BOB.1/OBF.1. J Biol Chem. 1995 Dec 15;270(50):29870-80
  • Latest
    J:231914 Stauss D, et al., The transcriptional coactivator Bob1 promotes the development of follicular T helper cells via Bcl6. EMBO J. 2016 Apr 15;35(8):881-98

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory