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Pou2af1 Gene Detail
Summary
  • Symbol
    Pou2af1
  • Name
    POU domain, class 2, associating factor 1
  • Synonyms
    Bob1, Bob-1, BOB.1, OBF-1, OBF.1, OCAB, OCA-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:105086
    NCBI Gene: 18985
  • Gene Overview
    MyGene.info: POU2AF1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:51213708-51240080 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 27.95 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    282 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105086
protein coding gene Chr9:51213690-51240080 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034798
protein coding gene Chr9:50133354-50164712 (+)
A/J MGP_AJ_G0034779
protein coding gene Chr9:48610718-48636946 (+)
AKR/J MGP_AKRJ_G0034707
protein coding gene Chr9:49623863-49651935 (+)
BALB/cJ MGP_BALBcJ_G0034771
protein coding gene Chr9:48359850-48386467 (+)
C3H/HeJ MGP_C3HHeJ_G0034481
protein coding gene Chr9:50116668-50143522 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035291
protein coding gene Chr9:51543636-51571139 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032204
protein coding gene Chr9:48068303-48094573 (+)
CAST/EiJ MGP_CASTEiJ_G0033803
protein coding gene Chr9:50057905-50085267 (+)
CBA/J MGP_CBAJ_G0034453
protein coding gene Chr9:53357880-53385494 (+)
DBA/2J MGP_DBA2J_G0034612
protein coding gene Chr9:48467386-48493809 (+)
FVB/NJ MGP_FVBNJ_G0034553
protein coding gene Chr9:47683050-47710113 (+)
LP/J MGP_LPJ_G0034693
protein coding gene Chr9:50501660-50529102 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034596
protein coding gene Chr9:54931541-54963110 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035312
protein coding gene Chr9:49617059-49644758 (+)
PWK/PhJ MGP_PWKPhJ_G0033508
protein coding gene Chr9:48442600-48469189 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033343
protein coding gene Chr9:49912126-49938221 (+)
WSB/EiJ MGP_WSBEiJ_G0033916
protein coding gene Chr9:49621923-49649964 (+)



Homology
more
  • Human Ortholog
    POU2AF1, POU class 2 associating factor 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    POU2AF1, POU class 2 associating factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BOB1, OBF1, OBF-1, OCAB
  • Links
    NCBI Gene ID: 5450
    neXtProt AC: NX_Q16633
    UniProt: Q16633

  • Chr Location
    11q23.1; chr11:111352251-111379432 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 3 alleles in 4 genetic backgrounds
    21 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit reduced numbers of mature B cells, absence of germinal centers, and low serum levels of non-IgM immunoglobulins.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032053 Ensembl Gene Model | MGI Sequence Detail 26373 C57BL/6J ±  kb
    transcript ENSMUST00000034554 Ensembl | MGI Sequence Detail 2548 Not Applicable  
    polypeptide ENSMUSP00000034554 Ensembl | MGI Sequence Detail 256 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 2
      cDNA 36
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-32126
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 9
      Gene Ontology 5
      Phenotypes 37
    • Earliest
      J:30126 Pfisterer P, et al., Functional characterization of the murine homolog of the B cell-specific coactivator BOB.1/OBF.1. J Biol Chem. 1995 Dec 15;270(50):29870-80
    • Latest
      J:264813 Carter S, et al., Loss of OcaB Prevents Age-Induced Fat Accretion and Insulin Resistance by Altering B-Lymphocyte Transition and Promoting Energy Expenditure. Diabetes. 2018 Jul;67(7):1285-1296

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory