About   Help   FAQ
Pou2af1
Gene Detail
Symbol

Name
ID
Pou2af1
POU domain, class 2, associating factor 1
MGI:105086
Synonyms
Bob1, Bob-1, BOB.1, OBF-1, OBF.1, OCAB, OCA-B
Feature Type
protein coding gene
Genetic Map
Chromosome 9
27.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:51213690-51240079 bp, + strand
From NCBI annotation of GRCm38

  26390 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4543  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Pou2af1

Human
homologs
Human Homolog POU2AF1, POU class 2 associating factor 1
NCBI Gene ID 5450
neXtProt AC  NX_Q16633
Human Synonyms  BOB1, OBF1, OBF-1, OCAB
Human Chr (Location)  11q23.1; chr11:111352251-111379619 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
 
Homozygotes for targeted null mutations exhibit reduced numbers of mature B cells, absence of germinal centers, and low serum levels of non-IgM immunoglobulins.
 
Interactions
Pou2af1 interacts with 228 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process regulation of transcription, DNA-templated, transcription, DNA-templated
Component nucleus
Function DNA binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (198)    Tissues (194)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 151
RT-PCR 47
cDNA source data(35)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) Genomic(2) cDNA(35) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000032053 (Evidence)
Entrez Gene18985 (Evidence)
UniGene897
DFCITC1580604
DoTSDT.490430
NIA Mouse Gene IndexU010474
Consensus CDS ProjectCCDS23176.1
International Mouse Knockout Project StatusPou2af1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18985 NCBI Gene Model | MGI Sequence Detail 26390 C57BL/6J ±  kb
transcript NM_011136 RefSeq | MGI Sequence Detail 2566 C57BL/6 
polypeptide Q64693 UniProt | EBI | MGI Sequence Detail 256 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(283 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015389 POU, class 2, associating factor 1
Protein Ontology PR:000013034 POU domain class 2-associating factor 1
Graphical View of Protein Domain Structure
References
(Earliest) J:30126 Pfisterer P, et al., Functional characterization of the murine homolog of the B cell-specific coactivator BOB.1/OBF.1. J Biol Chem. 1995 Dec 15;270(50):29870-80
(Latest) J:190912 Karnowski A, et al., B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1. J Exp Med. 2012 Oct 22;209(11):2049-64
All references(70)
Other
accession IDs
MGD-MRK-32126

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/11/2014
MGI 5.20
The Jackson Laboratory