About   Help   FAQ
Slc1a1 Gene Detail
Summary
  • Symbol
    Slc1a1
  • Name
    solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
  • Synonyms
    D130048G10Rik, EAAC1, EAAT3, MEAAC1
  • Feature Type
    protein coding gene
  • IDs
    MGI:105083
    NCBI Gene: 20510
  • Gene Overview
    MyGene.info: SLC1A1
Location & Maps
more
  • Sequence Map
    Chr19:28835049-28913960 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      78912 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SLC1A1, solute carrier family 1 member 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC1A1, solute carrier family 1 member 1
    Orthology source: HomoloGene
  • Synonyms
    DCBXA, EAAC1, EAAT3, SCZD18
  • Links
    NCBI Gene ID: 6505
    neXtProt AC: NX_P43005

  • Chr Location
    9p24; chr9:4490427-4587469 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Slc1a1 mouse models; 1 with human SLC1A1 associations

Human Disease Mouse Models
       Dicarboxylic Aminoaciduria; DCBXA   OMIM: 222730 View 1 model
Glaucoma, Normal Tension, Susceptibility to   OMIM: 606657 View 1 model
       Schizophrenia 18; SCZD18   OMIM: 615232
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display reduced locomotor activity and excessive excretion of glutamate and aspartate.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033893 VEGA Gene Model | MGI Sequence Detail 78912 C57BL/6J ±  kb
transcript OTTMUST00000085484 VEGA | MGI Sequence Detail 3800 Not Applicable  
polypeptide OTTMUSP00000046182 VEGA | MGI Sequence Detail 523 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    395 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000014972 excitatory amino acid transporter 3
  • InterPro Domains
    IPR001991 Sodium:dicarboxylate symporter
    IPR018107 Sodium:dicarboxylate symporter, conserved site
Molecular
Reagents
less
  • All nucleic 57
    cDNA 54
    Primer pair 3

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-32123, MGI:2441941
References
more
  • Summaries
    All 74
    Developmental Gene Expression 10
    Diseases 2
    Gene Ontology 9
    Phenotypes 27
  • Earliest
    J:47073 Swarna M, et al., Dicarboxylic aminoaciduria associated with mental retardation. Hum Genet. 1989 Jun;82(3):299-300
  • Latest
    J:230946 Noro T, et al., Spermidine Ameliorates Neurodegeneration in a Mouse Model of Normal Tension Glaucoma. Invest Ophthalmol Vis Sci. 2015 Jul;56(8):5012-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/17/2016
MGI 6.03
The Jackson Laboratory