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Slc1a1
Gene Detail
Symbol

Name
ID
Slc1a1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
MGI:105083
Synonyms
D130048G10Rik, EAAC1, EAAT3, MEAAC1
Feature Type
protein coding gene
Genetic Map
Chromosome 19
23.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:28835049-28913960 bp, + strand
From VEGA annotation of GRCm38

  78912 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20881  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SLC1A1
Protein SuperFamily: glutamate/aspartate transport protein
Gene Tree: Slc1a1

Human
homologs
SLC1A1, solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6505
neXtProt AC: NX_P43005

Human Synonyms: DCBXA, EAAC1, EAAT3, SCZD18

Human Chr (Location): 9p24; chr9:4490427-4587469 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SLC1A1

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display reduced locomotor activity and excessive excretion of glutamate and aspartate.
 
Human Diseases Modeled in Mice Using Slc1a1 (2)    Mutations Annotated to Human Diseases (1)   
Interactions
Slc1a1 interacts with 253 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process cysteine transmembrane transport, cysteine transport, ...
Component apical plasma membrane, extracellular exosome, ...
Function cysteine transmembrane transporter activity, glutamate binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (254)    Tissues (185)    Images (42)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 208
RT-PCR 46
cDNA source data(51)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase slc1a1 ; ZFIN slc1a1    NEW 
Molecular
reagents
All nucleic(57) cDNA(54) Primer pair(3)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000033893 (Evidence)
Ensembl Gene Model ENSMUSG00000024935 (Evidence)
Entrez Gene 20510 (Evidence)
UniGene 246670
DFCI TC1602985, TC1577160
DoTS DT.101379424, DT.87056498, DT.487051
NIA Mouse Gene Index U019335
Consensus CDS Project CCDS29727.1
International Mouse Phenotyping Consortium Status Slc1a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033893 VEGA Gene Model | MGI Sequence Detail 78912 C57BL/6J ±  kb
transcript OTTMUST00000085484 VEGA | MGI Sequence Detail 3800 Not Applicable 
polypeptide OTTMUSP00000046182 VEGA | MGI Sequence Detail 523 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(395 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001991 Sodium:dicarboxylate symporter
InterPro IPR018107 Sodium:dicarboxylate symporter, conserved site
Protein Ontology PR:000014972 excitatory amino acid transporter 3
References
(Earliest) J:47073 Swarna M, et al., Dicarboxylic aminoaciduria associated with mental retardation. Hum Genet. 1989 Jun;82(3):299-300
(Latest) J:221799 Guitart K, et al., Prion protein regulates glutathione metabolism and neural glutamate and cysteine uptake via excitatory amino acid transporter 3. J Neurochem. 2015 May;133(4):558-71
All references(75)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-32123, MGI:2441941

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory