Slc1a1
Gene Detail

Symbol Name ID

Slc1a1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 MGI:105083

Synonyms

D130048G10Rik, EAAC1, EAAT3, MEAAC1

Feature Type

protein coding gene

Genetic Map

Chromosome 19

23.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr19:28835049-28913960 bp, + strand From VEGA annotation of GRCm38   78912 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20881  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: glutamate/aspartate transport protein
Gene Tree: Slc1a1

Human homologs

Human Homolog		SLC1A1, solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
NCBI Gene ID		6505
neXtProt AC		NX_P43005
Human Synonyms		EAAC1, EAAT3
Human Chr (Location)		9p24; chr9:4490427-4587469 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SLC1A1

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for disruptions in this gene display reduced locomotor activity and excessive excretion of glutamate and aspartate.

 
Human Diseases Modeled Using Mouse Slc1a1 (2)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	amino acid transmembrane transport, D-aspartate import, ...
Component	integral to membrane, membrane, ...
Function	glutamate binding, glutamate:sodium symporter activity, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (232)    Tissues (164)    Images (40)
Theiler Stages: 19, 22, 23, 28

Assay Type	Results
RNA in situ	186
RT-PCR	46

cDNA source data(51)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(57) cDNA(54) Primer pair(3)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000033893 (Evidence)
Ensembl Gene Model	ENSMUSG00000024935 (Evidence)
Entrez Gene	20510 (Evidence)
UniGene	246670
DFCI	TC1577160, TC1602985
DoTS	DT.101379424, DT.487051, DT.87056498
NIA Mouse Gene Index	U019335
Consensus CDS Project	CCDS29727.1
International Mouse Knockout Project Status	Slc1a1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033893	VEGA Gene Model | MGI Sequence Detail	78912	C57BL/6J
transcript	OTTMUST00000085484	VEGA | MGI Sequence Detail	3800	Not Applicable
polypeptide	OTTMUSP00000046182	VEGA | MGI Sequence Detail	523	Not Applicable

All sequences(35) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(47 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001991	Sodium:dicarboxylate symporter
InterPro	IPR018107	Sodium:dicarboxylate symporter, conserved site
Protein Ontology	PR:000014972	excitatory amino acid transporter 3

References

(Earliest) J:47073 Swarna M, et al., Dicarboxylic aminoaciduria associated with mental retardation. Hum Genet. 1989 Jun;82(3):299-300
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(68)

Other accession IDs

MGD-MRK-32123, MGI:2441941