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Slc1a1
Gene Detail
 Symbol
Name
ID
Slc1a1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
MGI:105083
Synonyms D130048G10Rik, EAAC1, EAAT3, MEAAC1
Feature Type protein coding gene
Genetic Map
Chromosome 19
23.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:28835049-28913960 bp, + strand
From VEGA annotation of GRCm38

  78912 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20881  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: glutamate/aspartate transport protein
Gene Tree: Slc1a1

Human
homologs
Human Homolog SLC1A1, solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
NCBI Gene ID 6505
neXtProt AC  NX_P43005
Human Synonyms  EAAC1, EAAT3, SCZD18
Human Chr (Location)  9p24; chr9:4490427-4587469 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SLC1A1
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display reduced locomotor activity and excessive excretion of glutamate and aspartate.
 
Human Diseases Modeled Using Mouse Slc1a1 (2)    Alleles Annotated to Human Diseases(1)   
Interactions
Slc1a1 interacts with 254 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process D-aspartate import, dicarboxylic acid transport, ...
Component extracellular vesicular exosome, integral component of membrane, ...
Function glutamate binding, glutamate:sodium symporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (254)    Tissues (185)    Images (42)
Theiler Stages: 19, 22, 23, 26, 28
Assay TypeResults
RNA in situ 208
RT-PCR 46
cDNA source data(51)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(57) cDNA(54) Primer pair(3)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000033893 (Evidence)
Ensembl Gene ModelENSMUSG00000024935 (Evidence)
Entrez Gene20510 (Evidence)
UniGene246670
DFCITC1577160, TC1602985
DoTSDT.101379424, DT.487051, DT.87056498
NIA Mouse Gene IndexU019335
Consensus CDS ProjectCCDS29727.1
International Mouse Knockout Project StatusSlc1a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033893 VEGA Gene Model | MGI Sequence Detail 78912 C57BL/6J ±  kb
transcript OTTMUST00000085484 VEGA | MGI Sequence Detail 3800 Not Applicable 
polypeptide OTTMUSP00000046182 VEGA | MGI Sequence Detail 523 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(2) UniProt(4)
Polymorphisms SNPs within 2kb(395 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001991 Sodium:dicarboxylate symporter
InterPro IPR018107 Sodium:dicarboxylate symporter, conserved site
Protein Ontology PR:000014972 excitatory amino acid transporter 3
References (Earliest) J:47073 Swarna M, et al., Dicarboxylic aminoaciduria associated with mental retardation. Hum Genet. 1989 Jun;82(3):299-300
(Latest) J:210853 Cao J, et al., Glutamate transporter type 3 regulates mouse hippocampal GluR1 trafficking. Biochim Biophys Acta. 2014 Jun;1840(6):1640-5
All references(73)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-32123, MGI:2441941

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory