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Ssr1
Gene Detail
 Symbol
Name
ID
Ssr1
signal sequence receptor, alpha
MGI:105082
Synonyms SSR, TRAPalpha
Feature Type protein coding gene
Genetic Map
Chromosome 13
17.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:37971401-37994190 bp, - strand
From NCBI annotation of GRCm38

  22790 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2368  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: translocon-associated protein alpha subunit
Gene Tree: Ssr1

Human
homologs
Human Homolog SSR1, signal sequence receptor, alpha
NCBI Gene ID 6745
neXtProt AC  NX_P43307
Human Synonyms  TRAPA
Human Chr (Location)  6p24.3; chr6:7281050-7313308 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(6) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in neonatal lethality, subcutaneous edema, and cardiac defects, including absence of septation of the proximal part of the outflow tract, double outlet right ventricle, persistent truncus arteriosis, and abnormal development of the endocardial cushion.
 
Interactions
Ssr1 interacts with 513 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Component endoplasmic reticulum, endoplasmic reticulum membrane, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (266)    Tissues (68)    Images (31)
Theiler Stages: 17, 20, 22, 23
Assay TypeResults
RNA in situ 266
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(24)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000021427 (Evidence)
Entrez Gene107513 (Evidence)
DFCITC1573438, TC1588481, TC1594476, TC1600615, TC1639013
DoTSDT.101183545, DT.101386313, DT.486660, DT.494504, DT.91324046
NIA Mouse Gene IndexU034695, U348879
Consensus CDS ProjectCCDS26459.1
International Mouse Knockout Project StatusSsr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 107513 NCBI Gene Model | MGI Sequence Detail 22790 C57BL/6J ±  kb
transcript NM_025965 RefSeq | MGI Sequence Detail 9306 C57BL/6 
polypeptide Q9CY50 UniProt | EBI | MGI Sequence Detail 286 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(6) UniProt(4)
Polymorphisms SNPs within 2kb(218 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005595 Translocon-associated protein (TRAP), alpha subunit
Protein Ontology PR:000015659 translocon-associated protein subunit alpha
Graphical View of Protein Domain Structure
References (Earliest) J:28191 Antony C, et al., Developmental regulation of membrane traffic organization during synaptogenesis in mouse diaphragm muscle. J Cell Biol. 1995 Aug;130(4):959-68
(Latest) J:177067 Zhang B, et al., Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of {alpha}1-antitrypsin. Blood. 2011 Sep 22;118(12):3384-91
All references(41)
Other
accession IDs
MGD-MRK-32122, MGI:1914350, MGI:2145188, MGI:2145248

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory