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Ssr1
Gene Detail
Symbol

Name
ID
Ssr1
signal sequence receptor, alpha
MGI:105082
Synonyms
SSR, TRAPalpha
Feature Type
protein coding gene
Genetic Map
Chromosome 13
17.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:37971401-37994190 bp, - strand
From Ensembl annotation of GRCm38

  22790 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2368  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: translocon-associated protein alpha subunit
Gene Tree: Ssr1

Human
homologs
Human Homolog SSR1, signal sequence receptor, alpha
NCBI Gene ID 6745
neXtProt AC  NX_P43307
Human Synonyms  TRAPA
Human Chr (Location)  6p24.3; chr6:7281050-7313308 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(6) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in neonatal lethality, subcutaneous edema, and cardiac defects, including absence of septation of the proximal part of the outflow tract, double outlet right ventricle, persistent truncus arteriosis, and abnormal development of the endocardial cushion.
 
Interactions
Ssr1 interacts with 513 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Component endoplasmic reticulum, endoplasmic reticulum membrane, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (266)    Tissues (68)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 266
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(24)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000021427 (Evidence)
Entrez Gene107513 (Evidence)
DFCITC1573438, TC1588481, TC1639013, TC1600615, TC1594476
DoTSDT.91324046, DT.101183545, DT.494504, DT.486660, DT.101386313
NIA Mouse Gene IndexU348879, U034695
Consensus CDS ProjectCCDS26459.1
International Mouse Knockout Project StatusSsr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021427 Ensembl Gene Model | MGI Sequence Detail 22790 C57BL/6J ±  kb
transcript ENSMUST00000021864 Ensembl | MGI Sequence Detail 9306 Not Applicable 
polypeptide ENSMUSP00000021864 Ensembl | MGI Sequence Detail 286 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(6) UniProt(7)
Polymorphisms
SNPs within 2kb(218 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005595 Translocon-associated protein (TRAP), alpha subunit
Protein Ontology PR:000015659 translocon-associated protein subunit alpha
References
(Earliest) J:28191 Antony C, et al., Developmental regulation of membrane traffic organization during synaptogenesis in mouse diaphragm muscle. J Cell Biol. 1995 Aug;130(4):959-68
(Latest) J:213829 Bard-Chapeau EA, et al., Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects. PLoS One. 2014;9(2):e89397
All references(42)
Other
accession IDs
MGD-MRK-32122, MGI:1914350, MGI:2145188, MGI:2145248

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory