About   Help   FAQ
Ssr1
Gene Detail
Symbol

Name
ID
Ssr1
signal sequence receptor, alpha
MGI:105082
Synonyms
SSR, TRAPalpha
Feature Type
protein coding gene
Genetic Map
Chromosome 13
17.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:37971401-37994190 bp, - strand
From Ensembl annotation of GRCm38

  22790 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2368  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SSR1
Protein SuperFamily: translocon-associated protein alpha subunit
Gene Tree: Ssr1

Human
homologs
SSR1, signal sequence receptor, alpha
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6745
neXtProt AC: NX_P43307

Human Synonyms: TRAPA

Human Chr (Location): 6p24.3; chr6:7281143-7313314 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(6) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in neonatal lethality, subcutaneous edema, and cardiac defects, including absence of septation of the proximal part of the outflow tract, double outlet right ventricle, persistent truncus arteriosis, and abnormal development of the endocardial cushion.
 
Interactions
Ssr1 interacts with 512 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Component endoplasmic reticulum, endoplasmic reticulum membrane, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (266)    Tissues (68)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 266
cDNA source data(24)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ssr1    NEW 
Molecular
reagents
All nucleic(24) cDNA(24)
Microarray probesets(7)
Other database
links
Ensembl Gene Model ENSMUSG00000021427 (Evidence)
Entrez Gene 107513 (Evidence)
DFCI TC1594476, TC1588481, TC1573438, TC1600615, TC1639013
DoTS DT.101386313, DT.101183545, DT.486660, DT.91324046, DT.494504
NIA Mouse Gene Index U348879, U034695
Consensus CDS Project CCDS26459.1
International Mouse Phenotyping Consortium Status Ssr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021427 Ensembl Gene Model | MGI Sequence Detail 22790 C57BL/6J ±  kb
transcript ENSMUST00000021864 Ensembl | MGI Sequence Detail 9306 Not Applicable 
polypeptide ENSMUSP00000021864 Ensembl | MGI Sequence Detail 286 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(218 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005595 Translocon-associated protein (TRAP), alpha subunit
Protein Ontology PR:000015659 translocon-associated protein subunit alpha
References
(Earliest) J:28191 Antony C, et al., Developmental regulation of membrane traffic organization during synaptogenesis in mouse diaphragm muscle. J Cell Biol. 1995 Aug;130(4):959-68
(Latest) J:213829 Bard-Chapeau EA, et al., Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects. PLoS One. 2014;9(2):e89397
All references(41)
Other
accession IDs
MGD-MRK-32122, MGI:1914350, MGI:2145188, MGI:2145248

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/30/2015
MGI 5.22
The Jackson Laboratory