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Slc9a2
Gene Detail
Symbol

Name
ID
Slc9a2
solute carrier family 9 (sodium/hydrogen exchanger), member 2
MGI:105075
Synonyms
2210416H12Rik, 4932415O19Rik, NHE2
Feature Type
protein coding gene
Genetic Map
Chromosome 1
19.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:40680574-40769273 bp, + strand
From VEGA annotation of GRCm38

  88700 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20661  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Slc9a2

Human
homologs
Human Homolog   SLC9A2, solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
NCBI Gene ID 6549
neXtProt AC  NX_Q9UBY0
Human Synonyms  NHE2
Human Chr (Location)  2q11.2; chr2:102619689-102711350 (+)  GRCh38.p2
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Gastric acid secretion is impaired in homozygous mutant mice. The gastric mucosa becomes inflamed and exhibits an altered cellular composition. Mutant mice do not breed well.
 
Phenotype Images(3)
Interactions
Slc9a2 interacts with 173 markers (Mir7-2, Mir7b, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process hydrogen ion transmembrane transport, protein localization, ...
Component brush border
Function sodium:proton antiporter activity
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (87)    Tissues (44)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 73
RT-PCR 14
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) Genomic(1) cDNA(20) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000050475 (Evidence)
Ensembl Gene ModelENSMUSG00000026062 (Evidence)
Entrez Gene226999 (Evidence)
UniGene256414
DFCITC1586679, TC1600826, TC1623730
DoTSDT.40138781, DT.101290038
NIA Mouse Gene IndexU118277, U000204
Consensus CDS ProjectCCDS14914.1
International Mouse Knockout Project StatusSlc9a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050475 VEGA Gene Model | MGI Sequence Detail 88700 C57BL/6J ±  kb
transcript OTTMUST00000128063 VEGA | MGI Sequence Detail 5019 Not Applicable 
polypeptide OTTMUSP00000068961 VEGA | MGI Sequence Detail 814 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(596 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006153 Cation/H+ exchanger
InterPro IPR018422 Cation/H+ exchanger, CPA1 family
InterPro IPR004709 Na+/H+ exchanger
InterPro IPR001953 Na+/H+ exchanger, isoform 2 (NHE2)
Protein Ontology PR:000015213 sodium/hydrogen exchanger 2
References
(Earliest) J:17335 Szpirer C, et al., Chromosomal assignment of four genes encoding Na/H exchanger isoforms in human and rat. Mamm Genome. 1994 Mar;5(3):153-9
(Latest) J:215845 Singh AK, et al., Molecular transport machinery involved in orchestrating luminal acid-induced duodenal bicarbonate secretion in vivo. J Physiol. 2013 Nov 1;591(Pt 21):5377-91
All references(61)
Other
accession IDs
MGD-MRK-32115, MGI:1917419, MGI:2138533, MGI:3036276

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory