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Slc9a2 Gene Detail
Summary
  • Symbol
    Slc9a2
  • Name
    solute carrier family 9 (sodium/hydrogen exchanger), member 2
  • Synonyms
    2210416H12Rik, 4932415O19Rik, NHE2
  • Feature Type
    protein coding gene
  • IDs
    MGI:105075
    NCBI Gene: 226999
  • Gene Overview
    MyGene.info: SLC9A2
Location & Maps
more
  • Sequence Map
    Chr1:40680574-40769273 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      88700 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 19.66 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    SLC9A2, solute carrier family 9 member A2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC9A2, solute carrier family 9 member A2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NHE2
  • Links
    NCBI Gene ID: 6549
    neXtProt AC: NX_Q9UBY0

  • Chr Location
    2q11.2; chr2:102619689-102711350 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    3 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    2
  • Chemically induced (other)
    1
  • Targeted
    1
  • Genomic Mutations
    1 involving Slc9a2
  • Incidental Mutations
Gastric acid secretion is impaired in homozygous mutant mice. The gastric mucosa becomes inflamed and exhibits an altered cellular composition. Mutant mice do not breed well.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050475 VEGA Gene Model | MGI Sequence Detail 88700 C57BL/6J ±  kb
transcript OTTMUST00000128063 VEGA | MGI Sequence Detail 5019 Not Applicable  
polypeptide OTTMUSP00000068961 VEGA | MGI Sequence Detail 814 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    593 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR006153 Cation/H+ exchanger
    IPR018422 Cation/H+ exchanger, CPA1 family
    IPR004709 Na+/H+ exchanger
    IPR001953 Na+/H+ exchanger, isoform 2 (NHE2)
    IPR032103 Sodium/hydrogen exchanger, regulatory region
Molecular
Reagents
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  • All nucleic 24
    Genomic 1
    cDNA 20
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-32115, MGI:1917419, MGI:2138533, MGI:3036276
References
more
  • Summaries
    All 56
    Developmental Gene Expression 6
    Gene Ontology 4
    Phenotypes 23
  • Earliest
    J:17335 Szpirer C, et al., Chromosomal assignment of four genes encoding Na/H exchanger isoforms in human and rat. Mamm Genome. 1994 Mar;5(3):153-9
  • Latest
    J:215845 Singh AK, et al., Molecular transport machinery involved in orchestrating luminal acid-induced duodenal bicarbonate secretion in vivo. J Physiol. 2013 Nov 1;591(Pt 21):5377-91

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory