About   Help   FAQ
Slc9a2
Gene Detail
 Symbol
Name
ID
Slc9a2
solute carrier family 9 (sodium/hydrogen exchanger), member 2
MGI:105075
Synonyms 2210416H12Rik, 4932415O19Rik, NHE2
Feature Type protein coding gene
Genetic Map
Chromosome 1
19.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:40681712-40768885 bp, + strand
From NCBI annotation of GRCm38

  87174 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20661  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Slc9a2

Human
homologs
Human Homolog SLC9A2, solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
NCBI Gene ID 6549
neXtProt AC  NX_Q9UBY0
Human Synonyms  NHE2
Human Chr (Location)  2q11.2; chr2:102619707-102711350 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Gastric acid secretion is impaired in homozygous mutant mice. The gastric mucosa becomes inflamed and exhibits an altered cellular composition. Mutant mice do not breed well.
 
Phenotype Images(3)
Interactions
Slc9a2 interacts with 173 markers (Mir7-2, Mir7b, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process hydrogen ion transmembrane transport, ion transport, ...
Component brush border, integral component of membrane, ...
Function antiporter activity, sodium:proton antiporter activity
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (87)    Tissues (44)    Images (27)
Theiler Stages: 1, 2, 3, 5, 21, 23, 26, 28
Assay TypeResults
RNA in situ 73
RT-PCR 14
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) Genomic(1) cDNA(20) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000026062 (Evidence)
Entrez Gene226999 (Evidence)
UniGene256414
DFCITC1586679, TC1600826, TC1623730
DoTSDT.101290038, DT.40138781
NIA Mouse Gene IndexU000204, U118277
Consensus CDS ProjectCCDS14914.1
International Mouse Knockout Project StatusSlc9a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 226999 NCBI Gene Model | MGI Sequence Detail 87174 C57BL/6J ±  kb
transcript NM_001033289 RefSeq | MGI Sequence Detail 3493 Not Specified 
polypeptide NP_001028461 RefSeq | MGI Sequence Detail 814 Not Specified 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(592 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006153 Cation/H+ exchanger
InterPro IPR018422 Cation/H+ exchanger, CPA1 family
InterPro IPR004709 Na+/H+ exchanger
InterPro IPR001953 Na+/H+ exchanger, isoform 2 (NHE2)
Protein Ontology PR:000015213 sodium/hydrogen exchanger 2
References (Earliest) J:17335 Szpirer C, et al., Chromosomal assignment of four genes encoding Na/H exchanger isoforms in human and rat. Mamm Genome. 1994 Mar;5(3):153-9
(Latest) J:202055 Siyanov V, et al., NHE1 is the sodium-hydrogen exchanger active in acute intracellular pH regulation in preimplantation mouse embryos. Biol Reprod. 2013 Jun;88(6):157
All references(60)
Other
accession IDs
MGD-MRK-32115, MGI:1917419, MGI:2138533, MGI:3036276

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory