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Rab4b Gene Detail
Summary
  • Symbol
    Rab4b
  • Name
    RAB4B, member RAS oncogene family
  • Synonyms
    1500031G17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:105071
    NCBI Gene: 19342
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:27168433-27178883 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 15.84 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    33 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105071
 protein coding gene Chr7:27168424-27178896 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031898
 protein coding gene Chr7:25782287-25796473 (-)
A/J MGP_AJ_G0031877
 protein coding gene Chr7:25174944-25191687 (-)
AKR/J MGP_AKRJ_G0031807
 protein coding gene Chr7:25847504-25857887 (-)
BALB/cJ MGP_BALBcJ_G0031882
 protein coding gene Chr7:25404815-25415982 (-)
C3H/HeJ MGP_C3HHeJ_G0031604
 protein coding gene Chr7:26227332-26238146 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032347
 protein coding gene Chr7:26640027-26651011 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029399
 protein coding gene Chr7:26419355-26429555 (-)
CAST/EiJ MGP_CASTEiJ_G0030939
 protein coding gene Chr7:19523896-19538423 (-)
CBA/J MGP_CBAJ_G0031569
 protein coding gene Chr7:27804787-27816666 (-)
DBA/2J MGP_DBA2J_G0031721
 protein coding gene Chr7:24982927-24993308 (-)
FVB/NJ MGP_FVBNJ_G0031677
 protein coding gene Chr7:25065291-25076797 (-)
LP/J MGP_LPJ_G0031801
 protein coding gene Chr7:26124913-26138092 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031712
 protein coding gene Chr7:27418913-27429390 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032378
 protein coding gene Chr7:25379348-25389676 (-)
PWK/PhJ MGP_PWKPhJ_G0030663
 protein coding gene Chr7:20012607-20023517 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030497
 protein coding gene Chr7:16368291-16378533 (-)
WSB/EiJ MGP_WSBEiJ_G0031047
 protein coding gene Chr7:25665995-25676428 (-)



Homology
more
  • Human Ortholog
    RAB4B, RAB4B, member RAS oncogene family
  • Vertebrate Orthologs
    7
  • Human Ortholog
    RAB4B, RAB4B, member RAS oncogene family
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 53916
    neXtProt AC: NX_P61018
    UniProt: P61018

  • Chr Location
    19q13.2; chr19:40778219-40796944 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    684
  • Tissues
    6
  • cDNA Data
    72
  • Literature Summary
    2
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 19342 NCBI Gene Model | MGI Sequence Detail 10451 C57BL/6J ±  kb
transcript NM_029391 RefSeq | MGI Sequence Detail 1170 C57BL/6  
polypeptide Q91ZR1 UniProt | EBI | MGI Sequence Detail 213 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 73
    cDNA 73

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-32110, MGI:1922952
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:30578 Barbosa MD, et al., The Rab protein family: genetic mapping of six Rab genes in the mouse. Genomics. 1995 Dec 10;30(3):439-44
  • Latest
    J:271040 Gilleron J, et al., Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance. Cell Rep. 2018 Dec 18;25(12):3329-3341.e5
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/16/2021
MGI 6.16 		The Jackson Laboratory