Rab4b MGI Mouse Gene Detail - MGI:105071 - RAB4B, member RAS oncogene family

Symbol

Rab4b
Name

RAB4B, member RAS oncogene family
Synonyms

1500031G17Rik

Feature Type

protein coding gene
IDs

MGI:105071
NCBI Gene: 19342
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr7:27168433-27178883 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 15.84 cM
Mapping Data

2 experiments

SNPs within 2kb

33 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105071	protein coding gene	Chr7:27168424-27178896 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031898	protein coding gene	Chr7:25782287-25796473 (-)
A/J	MGP_AJ_G0031877	protein coding gene	Chr7:25174944-25191687 (-)
AKR/J	MGP_AKRJ_G0031807	protein coding gene	Chr7:25847504-25857887 (-)
BALB/cJ	MGP_BALBcJ_G0031882	protein coding gene	Chr7:25404815-25415982 (-)
C3H/HeJ	MGP_C3HHeJ_G0031604	protein coding gene	Chr7:26227332-26238146 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0032347	protein coding gene	Chr7:26640027-26651011 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029399	protein coding gene	Chr7:26419355-26429555 (-)
CAST/EiJ	MGP_CASTEiJ_G0030939	protein coding gene	Chr7:19523896-19538423 (-)
CBA/J	MGP_CBAJ_G0031569	protein coding gene	Chr7:27804787-27816666 (-)
DBA/2J	MGP_DBA2J_G0031721	protein coding gene	Chr7:24982927-24993308 (-)
FVB/NJ	MGP_FVBNJ_G0031677	protein coding gene	Chr7:25065291-25076797 (-)
LP/J	MGP_LPJ_G0031801	protein coding gene	Chr7:26124913-26138092 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031712	protein coding gene	Chr7:27418913-27429390 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032378	protein coding gene	Chr7:25379348-25389676 (-)
PWK/PhJ	MGP_PWKPhJ_G0030663	protein coding gene	Chr7:20012607-20023517 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0030497	protein coding gene	Chr7:16368291-16378533 (-)
WSB/EiJ	MGP_WSBEiJ_G0031047	protein coding gene	Chr7:25665995-25676428 (-)

Human Ortholog

RAB4B, RAB4B, member RAS oncogene family

Vertebrate Orthologs

7

Human Ortholog

RAB4B, RAB4B, member RAS oncogene family
Orthology source: HomoloGene, HGNC
Links

HGNC:9782

NCBI Gene ID: 53916

neXtProt AC: NX_P61018

UniProt: P61018
Chr Location

19q13.2; chr19:40778219-40796944 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 100632
1 human;1 mouse;1 rat;1 cattle;1 dog;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: RAB4B
Protein SuperFamily

Ras-related protein Rab
Gene Tree

Rab4b

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

1
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

7 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

19
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

53
Tissues

6
cDNA Data

72
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rab4b

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Rab4b interacts with 87 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

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All Sequences

46
RefSeq

2
UniProt

4
CCDS

CCDS21012.1
UniGene

482114

Ensembl

ENSMUSG00000053291 (Evidence)
NCBI Gene

19342

			Length	Strain/Species	Flank
genomic	19342	NCBI Gene Model \| MGI Sequence Detail	10451	C57BL/6J	± kb
transcript	NM_029391	RefSeq \| MGI Sequence Detail	1170	C57BL/6
polypeptide	Q91ZR1	UniProt \| EBI \| MGI Sequence Detail	213	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000013632 Ras-related protein Rab-4B

(term hierarchy)
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR041819 Rab4

IPR001806 Small GTPase

IPR005225 Small GTP-binding protein domain

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All nucleic 73

cDNA 73

Microarray probesets 3

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MGD-MRK-32110, MGI:1922952

Summaries

All 31

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 5
Earliest

J:30578 Barbosa MD, et al., The Rab protein family: genetic mapping of six Rab genes in the mouse. Genomics. 1995 Dec 10;30(3):439-44
Latest

J:271040 Gilleron J, et al., Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance. Cell Rep. 2018 Dec 18;25(12):3329-3341.e5

TSS for Rab4b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr71362	Chr7:27178912-27178923 (-)	-35 bp
Tssr71361	Chr7:27178835-27178888 (-)	21 bp
Tssr71360	Chr7:27178814-27178829 (-)	61 bp
Tssr71359	Chr7:27174581-27174603 (-)	4,291 bp
Tssr71358	Chr7:27174552-27174576 (-)	4,319 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/07/2020 MGI 6.14