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Rab4a
Gene Detail
Symbol

Name
ID
Rab4a
RAB4A, member RAS oncogene family
MGI:105069
Synonyms
Rab4
Feature Type
protein coding gene
Genetic Map
Chromosome 8
72.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:123805985-123835287 bp, + strand
From VEGA annotation of GRCm38

  29303 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:101538  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: RAB4A
Protein SuperFamily: Ras-related protein Rab
Gene Tree: Rab4a

Human
homologs
RAB4A, RAB4A, member RAS oncogene family
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5867
neXtProt AC: NX_P20338

Human Synonyms: HRES1, HRES-1, HRES-1/RAB4, RAB4

Human Chr (Location): 1q42-q43; chr1:229271062-229305894 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Rab4a interacts with 77 markers (Mir20a, Mir23a, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process antigen processing and presentation, intracellular protein transport, ...
Component cytoplasm, cytosol, ...
Function ATPase activator activity, ATPase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (29)    Tissues (6)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 29
cDNA source data(56)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN rab4a    NEW 
Molecular
reagents
All nucleic(57) cDNA(57)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000030744 (Evidence)
Ensembl Gene Model ENSMUSG00000019478 (Evidence)
Entrez Gene 19341 (Evidence)
UniGene 9221
DFCI TC1580726, TC1603518, TC1674163
DoTS DT.532528
NIA Mouse Gene Index U009947
Consensus CDS Project CCDS52703.1
International Mouse Phenotyping Consortium Status Rab4a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030744 VEGA Gene Model | MGI Sequence Detail 29303 C57BL/6J ±  kb
transcript OTTMUST00000076111 VEGA | MGI Sequence Detail 1419 Not Applicable 
polypeptide OTTMUSP00000040010 VEGA | MGI Sequence Detail 218 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(267 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR003579 Small GTPase superfamily, Rab type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000013631 ras-related protein Rab-4A
References
(Earliest) J:30578 Barbosa MD, et al., The Rab protein family: genetic mapping of six Rab genes in the mouse. Genomics. 1995 Dec 10;30(3):439-44
(Latest) J:186307 Peng C, et al., Ablation of vacuole protein sorting 18 (Vps18) gene leads to neurodegeneration and impaired neuronal migration by disrupting multiple vesicle transport pathways to lysosomes. J Biol Chem. 2012 Aug 1;
All references(37)
Other
accession IDs
MGD-MRK-32108, MGI:2142629

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory