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Rab10 Gene Detail
Summary
  • Symbol
    Rab10
  • Name
    RAB10, member RAS oncogene family
  • Feature Type
    protein coding gene
  • IDs
    MGI:105066
    NCBI Gene: 19325
  • Gene Overview
    MyGene.info: RAB10
  • Alliance
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:3247428-3309969 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 1.71 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    199 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105066
protein coding gene Chr12:3247428-3309969 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019555
protein coding gene Chr12:19782-86705 (-)
A/J MGP_AJ_G0019522
protein coding gene Chr12:114351-178310 (-)
AKR/J MGP_AKRJ_G0019492
protein coding gene Chr12:212832-282275 (-)
BALB/cJ MGP_BALBcJ_G0019497
protein coding gene Chr12:106633-169049 (-)
C3H/HeJ MGP_C3HHeJ_G0019303
protein coding gene Chr12:15774-80215 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019947
protein coding gene Chr12:38418-110869 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017571
protein coding gene Chr12:59622-116402 (-)
CAST/EiJ MGP_CASTEiJ_G0018858
protein coding gene Chr12:60411-125407 (-)
CBA/J MGP_CBAJ_G0019274
protein coding gene Chr12:239200-305341 (-)
DBA/2J MGP_DBA2J_G0019387
protein coding gene Chr12:66262-132201 (-)
FVB/NJ MGP_FVBNJ_G0019378
protein coding gene Chr12:83467-150799 (-)
LP/J MGP_LPJ_G0019458
protein coding gene Chr12:59516-125670 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019411
protein coding gene Chr12:66102-138752 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019985
protein coding gene Chr12:14153-77513 (-)
PWK/PhJ MGP_PWKPhJ_G0018624
protein coding gene Chr12:66333-134323 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018415
protein coding gene Chr12:73957-148060 (-)
WSB/EiJ MGP_WSBEiJ_G0018910
protein coding gene Chr12:43309-112955 (-)



Homology
more
  • Human Ortholog
    RAB10, RAB10, member RAS oncogene family
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RAB10, RAB10, member RAS oncogene family
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 10890
    neXtProt AC: NX_P61026
    UniProt: P61026

  • Chr Location
    2p23.3; chr2:26033860-26137454 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic growth and development at E7.5 with reduced cell proliferation and complete resorption by E9.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19325 NCBI Gene Model | MGI Sequence Detail 62542 C57BL/6J ±  kb
    transcript NM_016676 RefSeq | MGI Sequence Detail 3531 C57BL/6  
    polypeptide P61027 UniProt | EBI | MGI Sequence Detail 200 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 28

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-32105, MGI:2145003
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 1
      Gene Ontology 12
      Phenotypes 9
    • Earliest
      J:30578 Barbosa MD, et al., The Rab protein family: genetic mapping of six Rab genes in the mouse. Genomics. 1995 Dec 10;30(3):439-44
    • Latest
      J:263149 Zhang ZH, et al., Rab10 Disruption Results in Delayed OPC Maturation. Cell Mol Neurobiol. 2017 Oct;37(7):1303-1310

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory