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Slc9a3
Gene Detail
Symbol

Name
ID
Slc9a3
solute carrier family 9 (sodium/hydrogen exchanger), member 3
MGI:105064
Synonyms
9030624O13Rik, NHE3, NHE-3
Feature Type
protein coding gene
Genetic Map
Chromosome 13
40.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr13:74121515-74166064 bp, + strand
From Ensembl annotation of GRCm38

  44550 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55804  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: SLC9A3
Gene Tree: Slc9a3

Human
homologs
SLC9A3, solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6550
neXtProt AC: NX_P48764

Human Synonyms: NHE3

Human Chr (Location): 5p15.3; chr5:470510-570428 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutant mice have diarrhea associated with defects of renal and intestinal absorption. Males are infertile.
 
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process cation transport, hydrogen ion transmembrane transport, ...
Component apical plasma membrane, brush border, ...
Function antiporter activity, PDZ domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (75)    Tissues (61)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 47
RT-PCR 22
RNase protection 2
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN slc9a3.1, slc9a3.2    NEW 
Molecular
reagents
All nucleic(10) cDNA(6) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000036123 (Evidence)
Entrez Gene 105243 (Evidence)
DFCI TC1631201, TC1654288, TC1753574
DoTS DT.110976097, DT.40176361
NIA Mouse Gene Index U015012
Consensus CDS Project CCDS36731.1
International Mouse Phenotyping Consortium Status Slc9a3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036123 Ensembl Gene Model | MGI Sequence Detail 44550 C57BL/6J ±  kb
transcript ENSMUST00000036208 Ensembl | MGI Sequence Detail 2490 Not Applicable 
polypeptide ENSMUSP00000038142 Ensembl | MGI Sequence Detail 829 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(6) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(361 from dbSNP Build 137)    SNPs within 2kb including multiple locations(365)
Protein-related
information
ResourceIDDescription
InterPro IPR006153 Cation/H+ exchanger
InterPro IPR018422 Cation/H+ exchanger, CPA1 family
InterPro IPR004709 Na+/H+ exchanger
InterPro IPR018410 Na+/H+ exchanger, isoforms 3/5
InterPro IPR011256 Regulatory factor, effector binding domain
Protein Ontology PR:000015214 sodium/hydrogen exchanger 3
References
(Earliest) J:31188 Pathak BG, et al., Mouse chromosomal location of four Na/H exchanger isoform genes. Genomics. 1996 Jan 15;31(2):261-3
(Latest) J:218378 Chen T, et al., Cyclic GMP Kinase II (cGKII) Inhibits NHE3 by Altering Its Trafficking and Phosphorylating NHE3 at Three Required Sites: IDENTIFICATION OF A MULTIFUNCTIONAL PHOSPHORYLATION SITE. J Biol Chem. 2015 Jan 23;290(4):1952-65
All references(84)
Other
accession IDs
MGD-MRK-32103, MGI:2145314

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory