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Slc9a3 Gene Detail
Summary
  • Symbol
    Slc9a3
  • Name
    solute carrier family 9 (sodium/hydrogen exchanger), member 3
  • Synonyms
    9030624O13Rik, NHE3, NHE-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:105064
    NCBI Gene: 105243
Location & Maps
more
  • Sequence Map
    Chr13:74121515-74166064 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      44550 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 40.15 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    SLC9A3, solute carrier family 9 member A3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC9A3, solute carrier family 9 member A3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DIAR8, NHE3, NHE-3
  • Links
    NCBI Gene ID: 6550
    neXtProt AC: NX_P48764

  • Chr Location
    5p15.33; chr5:470510-570428 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SLC9A3 associations

Human Disease Mouse Models
       Diarrhea 8, Secretory Sodium, Congenital; DIAR8   OMIM: 616868
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Slc9a3
  • Incidental Mutations
Homozygous mutant mice have diarrhea associated with defects of renal and intestinal absorption. Males are infertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036123 Ensembl Gene Model | MGI Sequence Detail 44550 C57BL/6J ±  kb
transcript ENSMUST00000036208 Ensembl | MGI Sequence Detail 2490 Not Applicable  
polypeptide ENSMUSP00000038142 Ensembl | MGI Sequence Detail 829 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    701 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 10
    cDNA 6
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-32103, MGI:2145314
References
more
  • Summaries
    All 86
    Developmental Gene Expression 6
    Gene Ontology 9
    Phenotypes 48
  • Earliest
    J:31188 Pathak BG, et al., Mouse chromosomal location of four Na/H exchanger isoform genes. Genomics. 1996 Jan 15;31(2):261-3
  • Latest
    J:235885 Chou SY, et al., CLIC4 regulates apical exocytosis and renal tube luminogenesis through retromer- and actin-mediated endocytic trafficking. Nat Commun. 2016 Jan 20;7:10412

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory