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Slc9a3 Gene Detail
Summary
  • Symbol
    Slc9a3
  • Name
    solute carrier family 9 (sodium/hydrogen exchanger), member 3
  • Synonyms
    9030624O13Rik, NHE3, NHE-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:105064
    NCBI Gene: 105243
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:74269576-74317561 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 13, 40.15 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    389 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105064
protein coding gene Chr13:74234374-74317561 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020759
protein coding gene Chr13:74619066-74664715 (+)
A/J MGP_AJ_G0020715
protein coding gene Chr13:71948331-71993969 (+)
AKR/J MGP_AKRJ_G0020689
protein coding gene Chr13:74203998-74249704 (+)
BALB/cJ MGP_BALBcJ_G0020712
protein coding gene Chr13:72442714-72488352 (+)
C3H/HeJ MGP_C3HHeJ_G0020506
protein coding gene Chr13:73889053-73936126 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021149
protein coding gene Chr13:77091064-77136406 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018716
protein coding gene Chr13:68774932-68825369 (+)
CAST/EiJ MGP_CASTEiJ_G0020023
protein coding gene Chr13:72966572-73013528 (+)
CBA/J MGP_CBAJ_G0020465
protein coding gene Chr13:79963664-80008210 (+)
DBA/2J MGP_DBA2J_G0020590
protein coding gene Chr13:71766170-71810711 (+)
FVB/NJ MGP_FVBNJ_G0020570
protein coding gene Chr13:70789942-70835591 (+)
LP/J MGP_LPJ_G0020663
protein coding gene Chr13:74850224-74895902 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020598
protein coding gene Chr13:78360532-78406200 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021188
protein coding gene Chr13:73522158-73567803 (+)
PWK/PhJ MGP_PWKPhJ_G0019777
protein coding gene Chr13:70509702-70555979 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019600
protein coding gene Chr13:70002346-70047440 (+)
WSB/EiJ MGP_WSBEiJ_G0020081
protein coding gene Chr13:74078418-74124080 (+)



Homology
more
  • Human Ortholog
    SLC9A3, solute carrier family 9 member A3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC9A3, solute carrier family 9 member A3
  • Synonyms
    DIAR8, NHE3, NHE-3
  • Links
    NCBI Gene ID: 6550
    neXtProt AC: NX_P48764
    UniProt: P48764

  • Chr Location
    5p15.33; chr5:470456-524449 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human SLC9A3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    72 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice have diarrhea associated with defects of renal and intestinal absorption. Males are infertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036123 Ensembl Gene Model | MGI Sequence Detail 47986 C57BL/6J ±  kb
    transcript ENSMUST00000225423 Ensembl | MGI Sequence Detail 2589 Not Applicable  
    polypeptide ENSMUSP00000153255 Ensembl | MGI Sequence Detail 862 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 7
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-32103, MGI:2145314
    References
    more
    • Summaries
      All 140
      Developmental Gene Expression 9
      Gene Ontology 9
      Phenotypes 72
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:342643 Oh Y, et al., Rhox8 homeobox gene ablation leads to rete testis abnormality and male subfertility in mice. Biol Reprod. 2023 Oct 13;109(4):520-532

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory