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Slc9a3
Gene Detail
 Symbol
Name
ID
Slc9a3
solute carrier family 9 (sodium/hydrogen exchanger), member 3
MGI:105064
Synonyms 9030624O13Rik, NHE3, NHE-3
Feature Type protein coding gene
Genetic Map
Chromosome 13
40.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr13:74121515-74166064 bp, + strand
From NCBI annotation of GRCm38

  44550 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55804  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Slc9a3

Human
homologs
Human Homolog SLC9A3, solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
NCBI Gene ID 6550
neXtProt AC  NX_P48764
Human Synonyms  NHE3
Human Chr (Location)  5p15.3; chr5:473219-524434 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice have diarrhea associated with defects of renal and intestinal absorption. Males are infertile.
 
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process hydrogen ion transmembrane transport, ion transport, ...
Component apical plasma membrane, brush border, ...
Function antiporter activity, PDZ domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (75)    Tissues (61)    Images (7)
Theiler Stages: 1, 2, 3, 4, 5, 26, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 47
RT-PCR 22
RNase protection 2
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(6) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000036123 (Evidence)
Entrez Gene105243 (Evidence)
DFCITC1631201, TC1654288, TC1753574
DoTSDT.110976097, DT.40176361
NIA Mouse Gene IndexU015012
Consensus CDS ProjectCCDS36731.1
International Mouse Knockout Project StatusSlc9a3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 105243 NCBI Gene Model | MGI Sequence Detail 44550 C57BL/6J ±  kb
transcript NM_001081060 RefSeq | MGI Sequence Detail 2490 Not Specified 
polypeptide NP_001074529 RefSeq | MGI Sequence Detail 829 Not Specified 

For the selected sequences
All sequences(26) RefSeq(6) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(361 from dbSNP Build 137)    SNPs within 2kb including multiple locations(365)
Protein-related
information
ResourceIDDescription
InterPro IPR006153 Cation/H+ exchanger
InterPro IPR018422 Cation/H+ exchanger, CPA1 family
InterPro IPR004709 Na+/H+ exchanger
InterPro IPR018410 Na+/H+ exchanger, isoforms 3/5
InterPro IPR011256 Regulatory factor, effector, bacterial
Protein Ontology PR:000015214 sodium/hydrogen exchanger 3
References (Earliest) J:31188 Pathak BG, et al., Mouse chromosomal location of four Na/H exchanger isoform genes. Genomics. 1996 Jan 15;31(2):261-3
(Latest) J:210564 Larmonier CB, et al., Reduced colonic microbial diversity is associated with colitis in NHE3-deficient mice. Am J Physiol Gastrointest Liver Physiol. 2013 Nov 15;305(10):G667-77
All references(81)
Other
accession IDs
MGD-MRK-32103, MGI:2145314

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory