Clcn2
Gene Detail

Symbol Name ID

Clcn2 chloride channel 2 MGI:105061

Synonyms

Clc2, ClC-2, nmf240

Feature Type

protein coding gene

Genetic Map

Chromosome 16

12.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr16:20702964-20717746 bp, - strand From VEGA annotation of GRCm38   14783 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3213  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Clcn2

Human homologs

Human Homolog		CLCN2, chloride channel, voltage-sensitive 2
NCBI Gene ID		1181
neXtProt AC		NX_P51788
Human Synonyms		CIC-2, clC-2, CLC2, ECA2, ECA3, EGI11, EGI3, EGMA, EJM6, EJM8
Human Chr (Location)		3q27-q28; chr3:184063973-184079439 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CLCN2

Alleles and phenotypes

All alleles(10) : Targeted(5) Gene trapped(4) Chemically induced(1)
 

Mice homozygous for a null allele exhibit abnormal brain morphology, male infertility, and abnormal eye morphology.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	cell differentiation involved in salivary gland development, chloride transport, ...
Component	chloride channel complex, dendrite, ...
Function	chloride channel activity, ion channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (376)    Tissues (70)    Images (43)
Theiler Stages: 12, 13, 19, 23, 25, 28

Assay Type	Results
RNA in situ	373
RT-PCR	3

cDNA source data(41)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(44) cDNA(43) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000028531 (Evidence)
Ensembl Gene Model	ENSMUSG00000022843 (Evidence)
Entrez Gene	12724 (Evidence)
UniGene	177761
DFCI	TC1579778, TC1630878
NIA Mouse Gene Index	U036893
Consensus CDS Project	CCDS28057.1
International Mouse Knockout Project Status	Clcn2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028531	VEGA Gene Model | MGI Sequence Detail	14783	C57BL/6J
transcript	OTTMUST00000070706	VEGA | MGI Sequence Detail	3128	Not Applicable
polypeptide	OTTMUSP00000036072	VEGA | MGI Sequence Detail	908	Not Applicable

All sequences(49) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(65 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002244	Chloride channel ClC-2
InterPro	IPR014743	Chloride channel, core
InterPro	IPR001807	Chloride channel, voltage gated
InterPro	IPR000644	Cystathionine beta-synthase, core
Protein Ontology	PR:000005529	chloride channel protein 2

References

(Earliest) J:29529 Lengeling A, et al., Chloride channel 2 gene (Clc2) maps to chromosome 16 of the mouse, extending a region of conserved synteny with human chromosome 3q. Genet Res. 1995 Oct;66(2):175-8
(Latest) J:182668 Jeworutzki E, et al., GlialCAM, a protein defective in a leukodystrophy, serves as a ClC-2 Cl(-) channel auxiliary subunit. Neuron. 2012 Mar 8;73(5):951-61
All references(55)

Other accession IDs

MGD-MRK-32100, MGI:3034882, MGI:3056296