About   Help   FAQ
Clcn2
Gene Detail
Symbol

Name
ID
Clcn2
chloride channel 2
MGI:105061
Synonyms
Clc2, ClC-2, nmf240
Feature Type
protein coding gene
Genetic Map
Chromosome 16
12.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:20702964-20717746 bp, - strand
From VEGA annotation of GRCm38

  14783 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3213  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CLCN2
Gene Tree: Clcn2

Human
homologs
CLCN2, chloride channel, voltage-sensitive 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1181
neXtProt AC: NX_P51788

Human Synonyms: CIC-2, clC-2, CLC2, ECA2, ECA3, EGI11, EGI3, EGMA, EJM6, EJM8, LKPAT

Human Chr (Location): 3q27.1; chr3:184346185-184361651 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human CLCN2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(1) Gene trapped(4) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit abnormal brain morphology, male infertility, and abnormal eye morphology.
 
Phenotype Images(2)
Interactions
Clcn2 interacts with 230 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (376)    Tissues (71)    Images (43)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 373
RT-PCR 3
cDNA source data(41)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase clcn2    NEW 
Molecular
reagents
All nucleic(44) cDNA(43) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000028531 (Evidence)
Ensembl Gene Model ENSMUSG00000022843 (Evidence)
Entrez Gene 12724 (Evidence)
UniGene 177761
DFCI TC1579778, TC1630878
NIA Mouse Gene Index U036893
Consensus CDS Project CCDS28057.1
International Mouse Phenotyping Consortium Status Clcn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028531 VEGA Gene Model | MGI Sequence Detail 14783 C57BL/6J ±  kb
transcript OTTMUST00000070706 VEGA | MGI Sequence Detail 3128 Not Applicable 
polypeptide OTTMUSP00000036072 VEGA | MGI Sequence Detail 908 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(10) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(77 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000644 CBS domain
InterPro IPR002244 Chloride channel ClC-2
InterPro IPR014743 Chloride channel, core
InterPro IPR001807 Chloride channel, voltage gated
Protein Ontology PR:000005529 chloride channel protein 2
References
(Earliest) J:29529 Lengeling A, et al., Chloride channel 2 gene (Clc2) maps to chromosome 16 of the mouse, extending a region of conserved synteny with human chromosome 3q. Genet Res. 1995 Oct;66(2):175-8
(Latest) J:219999 Catalan MA, et al., A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland. Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2263-8
All references(59)
Other
accession IDs
MGD-MRK-32100, MGI:3034882, MGI:3056296

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory