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Clcn2
Gene Detail
Symbol

Name
ID
Clcn2
chloride channel 2
MGI:105061
Synonyms
Clc2, ClC-2, nmf240
Feature Type
protein coding gene
Genetic Map
Chromosome 16
12.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:20702964-20717746 bp, - strand
From VEGA annotation of GRCm38

  14783 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3213  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Clcn2

Human
homologs
Human Homolog CLCN2, chloride channel, voltage-sensitive 2
NCBI Gene ID 1181
neXtProt AC  NX_P51788
Human Synonyms  CIC-2, clC-2, CLC2, ECA2, ECA3, EGI11, EGI3, EGMA, EJM6, EJM8, LKPAT
Human Chr (Location)  3q27.1; chr3:184346185-184361651 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human CLCN2
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(1) Gene trapped(4) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit abnormal brain morphology, male infertility, and abnormal eye morphology.
 
Phenotype Images(2)
Interactions
Clcn2 interacts with 230 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (376)    Tissues (71)    Images (43)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 373
RT-PCR 3
cDNA source data(41)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(44) cDNA(43) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000028531 (Evidence)
Ensembl Gene ModelENSMUSG00000022843 (Evidence)
Entrez Gene12724 (Evidence)
UniGene177761
DFCITC1579778, TC1630878
NIA Mouse Gene IndexU036893
Consensus CDS ProjectCCDS28057.1
International Mouse Knockout Project StatusClcn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028531 VEGA Gene Model | MGI Sequence Detail 14783 C57BL/6J ±  kb
transcript OTTMUST00000070706 VEGA | MGI Sequence Detail 3128 Not Applicable 
polypeptide OTTMUSP00000036072 VEGA | MGI Sequence Detail 908 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(5) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(77 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002244 Chloride channel ClC-2
InterPro IPR014743 Chloride channel, core
InterPro IPR001807 Chloride channel, voltage gated
InterPro IPR000644 Cystathionine beta-synthase, core
Protein Ontology PR:000005529 chloride channel protein 2
References
(Earliest) J:29529 Lengeling A, et al., Chloride channel 2 gene (Clc2) maps to chromosome 16 of the mouse, extending a region of conserved synteny with human chromosome 3q. Genet Res. 1995 Oct;66(2):175-8
(Latest) J:195944 Arnaiz I, et al., Changing expression of chloride channels during preimplantation mouse development. Reproduction. 2013 Jan;145(1):73-84
All references(58)
Other
accession IDs
MGD-MRK-32100, MGI:3034882, MGI:3056296

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory