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Cobl Gene Detail
Summary
  • Symbol
    Cobl
  • Name
    cordon-bleu WH2 repeat
  • Synonyms
    C530045F18Rik, mKIAA0633
  • Feature Type
    protein coding gene
  • IDs
    MGI:105056
    NCBI Gene: 12808
Location & Maps
more
  • Sequence Map
    Chr11:12236608-12464960 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      228353 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 7.30 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    COBL, cordon-bleu WH2 repeat protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    COBL, cordon-bleu WH2 repeat protein
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 23242
    neXtProt AC: NX_O75128

  • Chr Location
    7p12.1; chr7:51016212-51316818 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    11 phenotype references
Animals homozygous for this mutation do not display a phenotype. However, the allele exacerbates the neural tube defects seen in the loop tail mouse.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005168 VEGA Gene Model | MGI Sequence Detail 228353 C57BL/6J ±  kb
transcript OTTMUST00000011560 VEGA | MGI Sequence Detail 5615 Not Applicable  
polypeptide OTTMUSP00000005377 VEGA | MGI Sequence Detail 1337 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1385 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 52
    cDNA 50
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-32095, MGI:2444561
References
more
  • Summaries
    All 38
    Developmental Gene Expression 6
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:28764 Gasca S, et al., Characterization of a gene trap insertion into a novel gene, cordon-bleu, expressed in axial structures of the gastrulating mouse embryo. Dev Genet. 1995;17(2):141-54
  • Latest
    J:193189 Haag N, et al., The actin nucleator Cobl is crucial for Purkinje cell development and works in close conjunction with the F-actin binding protein Abp1. J Neurosci. 2012 Dec 5;32(49):17842-56

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory