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Cobl Gene Detail
Summary
  • Symbol
    Cobl
  • Name
    cordon-bleu WH2 repeat
  • Synonyms
    C530045F18Rik, mKIAA0633
  • Feature Type
    protein coding gene
  • IDs
    MGI:105056
    NCBI Gene: 12808
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:12236676-12464960 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 7.30 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1385 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105056
protein coding gene Chr11:12236608-12464960 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018049
protein coding gene Chr11:9550045-9787093 (-)
A/J MGP_AJ_G0018022
protein coding gene Chr11:9201364-9432120 (-)
AKR/J MGP_AKRJ_G0017986
protein coding gene Chr11:9579580-9813537 (-)
BALB/cJ MGP_BALBcJ_G0017990
protein coding gene Chr11:9238339-9468854 (-)
C3H/HeJ MGP_C3HHeJ_G0017803
protein coding gene Chr11:9473730-9721264 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018442
protein coding gene Chr11:9869428-10106424 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016100
protein coding gene Chr11:8742197-8971757 (-)
CAST/EiJ MGP_CASTEiJ_G0017365
protein coding gene Chr11:9496416-9733368 (-)
CBA/J MGP_CBAJ_G0017778
protein coding gene Chr11:10547447-10792996 (-)
DBA/2J MGP_DBA2J_G0017888
protein coding gene Chr11:9130620-9363772 (-)
FVB/NJ MGP_FVBNJ_G0017880
protein coding gene Chr11:9045015-9276866 (-)
LP/J MGP_LPJ_G0017959
protein coding gene Chr11:9630459-9868878 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017906
protein coding gene Chr11:10264254-10519970 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018483
protein coding gene Chr11:9620179-9873780 (-)
PWK/PhJ MGP_PWKPhJ_G0017145
protein coding gene Chr11:9168926-9403716 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016942
protein coding gene Chr11:9458563-9711863 (-)
WSB/EiJ MGP_WSBEiJ_G0017419
protein coding gene Chr11:9352379-9589471 (-)



Homology
more
  • Human Ortholog
    COBL, cordon-bleu WH2 repeat protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    COBL, cordon-bleu WH2 repeat protein
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 23242
    neXtProt AC: NX_O75128
    UniProt: O75128

  • Chr Location
    7p12.1; chr7:51016212-51316818 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    11 phenotype references
Animals homozygous for this mutation do not display a phenotype. However, the allele exacerbates the neural tube defects seen in the loop tail mouse.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12808 NCBI Gene Model | MGI Sequence Detail 228285 C57BL/6J ±  kb
transcript NM_172496 RefSeq | MGI Sequence Detail 5633 C57BL/6  
polypeptide Q5NBX1 UniProt | EBI | MGI Sequence Detail 1337 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 54
    cDNA 52
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-32095, MGI:2444561
References
more
  • Summaries
    All 44
    Developmental Gene Expression 9
    Gene Ontology 8
    Phenotypes 11
  • Earliest
    J:28764 Gasca S, et al., Characterization of a gene trap insertion into a novel gene, cordon-bleu, expressed in axial structures of the gastrulating mouse embryo. Dev Genet. 1995;17(2):141-54
  • Latest
    J:271615 Haag N, et al., The Actin Nucleator Cobl Is Critical for Centriolar Positioning, Postnatal Planar Cell Polarity Refinement, and Function of the Cochlea. Cell Rep. 2018 Aug 28;24(9):2418-2431.e6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory