Cobl MGI Mouse Gene Detail - MGI:105056

Symbol

Cobl
Name

cordon-bleu WH2 repeat
Synonyms

C530045F18Rik, mKIAA0633

Feature Type

protein coding gene
IDs

MGI:105056
NCBI Gene: 12808
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr11:12186676-12415022 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 7.30 cM
Mapping Data

4 experiments

SNPs within 2kb

1385 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105056	protein coding gene	Chr11:12186608-12415022 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018049	protein coding gene	Chr11:9550045-9787093 (-)
A/J	MGP_AJ_G0018022	protein coding gene	Chr11:9201364-9432120 (-)
AKR/J	MGP_AKRJ_G0017986	protein coding gene	Chr11:9579580-9813537 (-)
BALB/cJ	MGP_BALBcJ_G0017990	protein coding gene	Chr11:9238339-9468854 (-)
C3H/HeJ	MGP_C3HHeJ_G0017803	protein coding gene	Chr11:9473730-9721264 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018442	protein coding gene	Chr11:9869428-10106424 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016100	protein coding gene	Chr11:8742197-8971757 (-)
CAST/EiJ	MGP_CASTEiJ_G0017365	protein coding gene	Chr11:9496416-9733368 (-)
CBA/J	MGP_CBAJ_G0017778	protein coding gene	Chr11:10547447-10792996 (-)
DBA/2J	MGP_DBA2J_G0017888	protein coding gene	Chr11:9130620-9363772 (-)
FVB/NJ	MGP_FVBNJ_G0017880	protein coding gene	Chr11:9045015-9276866 (-)
LP/J	MGP_LPJ_G0017959	protein coding gene	Chr11:9630459-9868878 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017906	protein coding gene	Chr11:10264254-10519970 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018483	protein coding gene	Chr11:9620179-9873780 (-)
PWK/PhJ	MGP_PWKPhJ_G0017145	protein coding gene	Chr11:9168926-9403716 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016942	protein coding gene	Chr11:9458563-9711863 (-)
WSB/EiJ	MGP_WSBEiJ_G0017419	protein coding gene	Chr11:9352379-9589471 (-)

Human Ortholog

COBL, cordon-bleu WH2 repeat protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

COBL, cordon-bleu WH2 repeat protein
Links

HGNC:22199

NCBI Gene ID: 23242

neXtProt AC: NX_O75128

UniProt: O75128
Chr Location

7p12.1; chr7:51016212-51316818 (-) GRCh38

MGI Vertebrate Homology

Cobl stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: COBL
Gene Tree

Cobl

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

66
Endonuclease-mediated

2
Gene trapped

61
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

78 strains or lines available

Animals homozygous for this mutation do not display a phenotype. However, the allele exacerbates the neural tube defects seen in the loop tail mouse.

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All GO Annotations

53
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1025
Tissues

85
cDNA Data

51
Literature Summary

12

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA COBL

Xenbase cobl

ZFIN cobl

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All Sequences

98
RefSeq

32
UniProt

8
CCDS

CCDS36113.1, CCDS70142.1, CCDS70144.1

Ensembl

ENSMUSG00000020173 (Evidence)
NCBI Gene

12808

			Length	Strain/Species	Flank
genomic	12808	NCBI Gene Model \| MGI Sequence Detail	228347	C57BL/6J	± kb
transcript	NM_172496	RefSeq \| MGI Sequence Detail	5597	ZRU/MplStud
polypeptide	Q5NBX1	UniProt \| EBI \| MGI Sequence Detail	1337	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000005680 protein cordon-bleu

(term hierarchy)
PDB

3TU5, 4JHD, 5YPU, 6JBK, 6JCU, 6JH8, 6JH9
InterPro Domains

IPR019025 Cordon-bleu, ubiquitin-like domain

IPR039895 Protein cordon-bleu-like

IPR029071 Ubiquitin-like domain superfamily

IPR003124 WH2 domain

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All nucleic 55

cDNA 52

Primer pair 3

Microarray probesets 3

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MGD-MRK-32095, MGI:2444561

Summaries

All 53

Developmental Gene Expression 12

Gene Ontology 11

Phenotypes 16
Earliest

J:28764 Gasca S, et al., Characterization of a gene trap insertion into a novel gene, cordon-bleu, expressed in axial structures of the gastrulating mouse embryo. Dev Genet. 1995;17(2):141-54
Latest

J:329940 Juan AM, et al., Tissue-specific Grb10/Ddc insulator drives allelic architecture for cardiac development. Mol Cell. 2022 Oct 6;82(19):3613-3631.e7

TSS for Cobl:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr106930	Chr11:12414881-12414997 (-)	83 bp
Tssr106929	Chr11:12414850-12414879 (-)	157 bp
Tssr106928	Chr11:12414819-12414845 (-)	190 bp
Tssr106927	Chr11:12414746-12414759 (-)	269 bp
Tssr106926	Chr11:12379015-12379028 (-)	36,000 bp
Tssr106925	Chr11:12378969-12378991 (-)	36,042 bp
Tssr106924	Chr11:12362136-12362153 (-)	52,877 bp
Tssr106923	Chr11:12304027-12304032 (-)	110,992 bp
Tssr106922	Chr11:12259760-12259771 (-)	155,256 bp
Tssr106921	Chr11:12259732-12259746 (-)	155,283 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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