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Ksr1
Gene Detail
Symbol

Name
ID
Ksr1
kinase suppressor of ras 1
MGI:105051
Synonyms
B-KSR1, D11Bhm183e, D11Bhm184e
Feature Type
protein coding gene
Genetic Map
Chromosome 11
46.74 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:79013440-79146407 bp, - strand
From VEGA annotation of GRCm38

  132968 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8410  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: KSR1
Protein SuperFamily: kinase suppressor of Ras
Gene Tree: Ksr1

Human
homologs
KSR1, kinase suppressor of ras 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8844
neXtProt AC: NX_Q8IVT5

Human Synonyms: KSR, RSU2

Human Chr (Location): 17q11.2; chr17:27456464-27626441 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(14) Targeted(7)
Genomic Mutations involving Ksr1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutant mice exhibit disorganized hair follicles and a decreased susceptibility to papilloma formation.
 
Interactions
Ksr1 interacts with 244 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process intracellular signal transduction, positive regulation of MAPK cascade, ...
Component cytoplasm, endoplasmic reticulum, ...
Function ATP binding, MAP-kinase scaffold activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (48)    Tissues (31)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 19
Western blot 13
RT-PCR 16
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ksr1    NEW 
Molecular
reagents
All nucleic(20) Genomic(9) cDNA(7) Primer pair(3) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000000155 (Evidence)
Ensembl Gene Model ENSMUSG00000018334 (Evidence)
Entrez Gene 16706 (Evidence)
DFCI TC1586210, TC1624539, TC1670424, TC1641696, TC1627265
DoTS DT.55157101, DT.527592, DT.40170747, DT.101178996, DT.94236826
NIA Mouse Gene Index U033143
PDB 1KBF, 1KBE, 2LPE
Consensus CDS Project CCDS25117.1
International Mouse Phenotyping Consortium Status Ksr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000155 VEGA Gene Model | MGI Sequence Detail 132968 C57BL/6J ±  kb
transcript OTTMUST00000000478 VEGA | MGI Sequence Detail 5495 Not Applicable 
polypeptide OTTMUSP00000000212 VEGA | MGI Sequence Detail 873 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(23) UniProt(5)
Polymorphisms
SNPs within 2kb(751 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025561 Kinase suppressor of RAS, SAM-like domain
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR011009 Protein kinase-like domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
Protein Ontology PR:000009591 kinase suppressor of Ras 1
References
(Earliest) J:25181 Nehls M, et al., YAC/P1 contigs defining the location of 56 microsatellite markers and several genes across a 3.4-cM interval on mouse chromosome 11. Mamm Genome. 1995 May;6(5):321-31
(Latest) J:209645 Cullis J, et al., The RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1. Cancer Cell. 2014 Feb 10;25(2):181-95
All references(69)
Other
accession IDs
MGD-MRK-32090, MGD-MRK-35271, MGD-MRK-35272, MGI:106811, MGI:106812, MGI:2144543

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory