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Ksr1 Gene Detail
Summary
  • Symbol
    Ksr1
  • Name
    kinase suppressor of ras 1
  • Synonyms
    B-KSR1, D11Bhm183e, D11Bhm184e
  • Feature Type
    protein coding gene
  • IDs
    MGI:105051
    NCBI Gene: 16706
  • Gene Overview
    MyGene.info: KSR1
Location & Maps
more
  • Sequence Map
    Chr11:79013440-79146407 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      132968 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    KSR1, kinase suppressor of ras 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KSR1, kinase suppressor of ras 1
    Orthology source: HomoloGene
  • Synonyms
    KSR, RSU2
  • Links
    NCBI Gene ID: 8844
    neXtProt AC: NX_Q8IVT5

  • Chr Location
    17q11.2; chr17:27456464-27626441 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 2 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    22
  • Chemically induced (other)
    1
  • Gene trapped
    14
  • Targeted
    7
  • Genomic Mutations
    2 involving Ksr1
  • Incidental Mutations
Homozygous mutant mice exhibit disorganized hair follicles and a decreased susceptibility to papilloma formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000155 VEGA Gene Model | MGI Sequence Detail 132968 C57BL/6J ±  kb
transcript OTTMUST00000000478 VEGA | MGI Sequence Detail 5495 Not Applicable  
polypeptide OTTMUSP00000000212 VEGA | MGI Sequence Detail 873 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    753 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000009591 kinase suppressor of Ras 1
  • PDB
  • InterPro Domains
    IPR025561 Kinase suppressor of RAS, SAM-like domain
    IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR008271 Serine/threonine-protein kinase, active site
    IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
Molecular
Reagents
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  • All nucleic 20
    Genomic 9
    cDNA 7
    Primer pair 3
    Other 1

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-32090, MGD-MRK-35271, MGD-MRK-35272, MGI:106811, MGI:106812, MGI:2144543
References
more
  • Summaries
    All 67
    Developmental Gene Expression 2
    Gene Ontology 10
    Phenotypes 29
  • Earliest
    J:25181 Nehls M, et al., YAC/P1 contigs defining the location of 56 microsatellite markers and several genes across a 3.4-cM interval on mouse chromosome 11. Mamm Genome. 1995 May;6(5):321-31
  • Latest
    J:224351 Kortum RL, et al., Caveolin-1 is required for kinase suppressor of Ras 1 (KSR1)-mediated extracellular signal-regulated kinase 1/2 activation, H-RasV12-induced senescence, and transformation. Mol Cell Biol. 2014 Sep 15;34(18):3461-72

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory