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Ksr1 Gene Detail
Summary
  • Symbol
    Ksr1
  • Name
    kinase suppressor of ras 1
  • Synonyms
    B-KSR1, D11Bhm183e, D11Bhm184e
  • Feature Type
    protein coding gene
  • IDs
    MGI:105051
    NCBI Gene: 16706
  • Gene Overview
    MyGene.info: KSR1
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:79013440-79146407 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 46.74 cM, cytoband B5
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    753 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105051
protein coding gene Chr11:79013440-79146551 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018793
protein coding gene Chr11:80075385-80217895 (-)
A/J MGP_AJ_G0018760
protein coding gene Chr11:77004503-77138144 (-)
AKR/J MGP_AKRJ_G0018730
protein coding gene Chr11:79318689-79460500 (-)
BALB/cJ MGP_BALBcJ_G0018733
protein coding gene Chr11:77415130-77555055 (-)
C3H/HeJ MGP_C3HHeJ_G0018547
protein coding gene Chr11:79362083-79499149 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019185
protein coding gene Chr11:82549855-82690633 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016820
protein coding gene Chr11:73959995-74092513 (-)
CAST/EiJ MGP_CASTEiJ_G0018102
protein coding gene Chr11:79832388-79980049 (-)
CBA/J MGP_CBAJ_G0018518
protein coding gene Chr11:86129977-86286104 (-)
DBA/2J MGP_DBA2J_G0018626
protein coding gene Chr11:76567056-76701325 (-)
FVB/NJ MGP_FVBNJ_G0018615
protein coding gene Chr11:76161293-76303375 (-)
LP/J MGP_LPJ_G0018696
protein coding gene Chr11:80597040-80732585 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018642
protein coding gene Chr11:86514923-86647415 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019225
protein coding gene Chr11:79578766-79717595 (-)
PWK/PhJ MGP_PWKPhJ_G0017872
protein coding gene Chr11:77373565-77511733 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017663
protein coding gene Chr11:79191079-79325016 (-)
WSB/EiJ MGP_WSBEiJ_G0018154
protein coding gene Chr11:79396319-79537216 (-)



Homology
more
  • Human Ortholog
    KSR1, kinase suppressor of ras 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KSR1, kinase suppressor of ras 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KSR, RSU2
  • Links
    NCBI Gene ID: 8844
    neXtProt AC: NX_Q8IVT5
    UniProt: Q8IVT5

  • Chr Location
    17q11.2; chr17:27456441-27626438 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 2 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit disorganized hair follicles and a decreased susceptibility to papilloma formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018334 Ensembl Gene Model | MGI Sequence Detail 132968 C57BL/6J ±  kb
    transcript ENSMUST00000018478 Ensembl | MGI Sequence Detail 5495 Not Applicable  
    polypeptide ENSMUSP00000018478 Ensembl | MGI Sequence Detail 873 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 9
      cDNA 8
      Primer pair 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-32090, MGD-MRK-35271, MGD-MRK-35272, MGI:106811, MGI:106812, MGI:2144543
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 3
      Gene Ontology 14
      Phenotypes 32
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:261064 Germino EA, et al., Homozygous KSR1 deletion attenuates morbidity but does not prevent tumor development in a mouse model of RAS-driven pancreatic cancer. PLoS One. 2018;13(3):e0194998

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory