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P2ry1 Gene Detail
Summary
  • Symbol
    P2ry1
  • Name
    purinergic receptor P2Y, G-protein coupled 1
  • Synonyms
    P2Y1, P2Y1 receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:105049
    NCBI Gene: 18441
  • Gene Overview
    MyGene.info: P2RY1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:61002795-61008982 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 29.24 cM, cytoband E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105049
protein coding gene Chr3:61002785-61008982 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027255
protein coding gene Chr3:59966956-59973145 (+)
A/J MGP_AJ_G0027215
protein coding gene Chr3:58201307-58207496 (+)
AKR/J MGP_AKRJ_G0027185
protein coding gene Chr3:59358650-59364845 (+)
BALB/cJ MGP_BALBcJ_G0027228
protein coding gene Chr3:57944632-57950819 (+)
C3H/HeJ MGP_C3HHeJ_G0026971
protein coding gene Chr3:59548475-59554660 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027674
protein coding gene Chr3:62230383-62236570 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025028
protein coding gene Chr3:54922779-54928974 (+)
CAST/EiJ MGP_CASTEiJ_G0026423
protein coding gene Chr3:59742504-59748689 (+)
CBA/J MGP_CBAJ_G0026947
protein coding gene Chr3:64268282-64274467 (+)
DBA/2J MGP_DBA2J_G0027081
protein coding gene Chr3:57608987-57615180 (+)
FVB/NJ MGP_FVBNJ_G0027049
protein coding gene Chr3:56494430-56500617 (+)
LP/J MGP_LPJ_G0027192
protein coding gene Chr3:60813753-60819942 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027066
protein coding gene Chr3:68534084-68541513 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027732
protein coding gene Chr3:59276307-59282494 (+)
PWK/PhJ MGP_PWKPhJ_G0026155
protein coding gene Chr3:57257579-57263822 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025968
protein coding gene Chr3:58867062-58873284 (+)
WSB/EiJ MGP_WSBEiJ_G0026497
protein coding gene Chr3:59378406-59384591 (+)



Homology
more
  • Human Ortholog
    P2RY1, purinergic receptor P2Y1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    P2RY1, purinergic receptor P2Y1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    P2Y1, SARCC
  • Links
    NCBI Gene ID: 5028
    neXtProt AC: NX_P47900
    UniProt: P47900

  • Chr Location
    3q25.2; chr3:152834693-152841439 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for either one of two independently generated knock-out alleles exhibit decreased platelet aggregation, increased bleeding time, and resistance to induced thromboembolism.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027765 Ensembl Gene Model | MGI Sequence Detail 6188 C57BL/6J ±  kb
transcript ENSMUST00000029331 Ensembl | MGI Sequence Detail 3886 Not Applicable  
polypeptide ENSMUSP00000029331 Ensembl | MGI Sequence Detail 373 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-32088
References
more
  • Summaries
    All 82
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 7
    Phenotypes 38
  • Earliest
    J:25964 Tokuyama Y, et al., Cloning of rat and mouse P2Y purinoceptors. Biochem Biophys Res Commun. 1995 Jun 6;211(1):211-8
  • Latest
    J:256688 Heredia DJ, et al., Activity-induced Ca(2+) signaling in perisynaptic Schwann cells of the early postnatal mouse is mediated by P2Y1 receptors and regulates muscle fatigue. Elife. 2018 Jan 31;7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory