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Psmc5 Gene Detail
Summary
  • Symbol
    Psmc5
  • Name
    protease (prosome, macropain) 26S subunit, ATPase 5
  • Synonyms
    mSUG1, Rpt6
  • Feature Type
    protein coding gene
  • IDs
    MGI:105047
    NCBI Gene: 19184
  • Gene Overview
    MyGene.info: PSMC5
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:106256185-106263112 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 68.89 cM, cytoband E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    33 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105047
protein coding gene Chr11:106256154-106263120 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019300
protein coding gene Chr11:109545066-109553205 (+)
A/J MGP_AJ_G0019268
protein coding gene Chr11:104883120-104890026 (+)
AKR/J MGP_AKRJ_G0019237
protein coding gene Chr11:108010360-108017326 (+)
BALB/cJ MGP_BALBcJ_G0019242
protein coding gene Chr11:105283852-105298314 (+)
C3H/HeJ MGP_C3HHeJ_G0019051
protein coding gene Chr11:108299878-108306880 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019692
protein coding gene Chr11:112895656-112902649 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017316
protein coding gene Chr11:102160766-102167687 (+)
CAST/EiJ MGP_CASTEiJ_G0018604
protein coding gene Chr11:109355608-109362559 (+)
CBA/J MGP_CBAJ_G0019020
protein coding gene Chr11:117595359-117602777 (+)
DBA/2J MGP_DBA2J_G0019132
protein coding gene Chr11:104350950-104358007 (+)
FVB/NJ MGP_FVBNJ_G0019123
protein coding gene Chr11:103852317-103861695 (+)
LP/J MGP_LPJ_G0019202
protein coding gene Chr11:109984507-109994160 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019153
protein coding gene Chr11:116878862-116886863 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019729
protein coding gene Chr11:108502846-108510379 (+)
PWK/PhJ MGP_PWKPhJ_G0018369
protein coding gene Chr11:105447952-105455093 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018160
protein coding gene Chr11:108265938-108272775 (+)
WSB/EiJ MGP_WSBEiJ_G0018655
protein coding gene Chr11:108465831-108472325 (+)



Homology
more
  • Human Ortholog
    PSMC5, proteasome 26S subunit, ATPase 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PSMC5, proteasome 26S subunit, ATPase 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    p45, p45/SUG, S8, SUG1, SUG-1, TBP10, TRIP1
  • Links
    NCBI Gene ID: 5705
    neXtProt AC: NX_P62195
    UniProt: P62195

  • Chr Location
    17q23.3; chr17:63827410-63832027 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a phospho-mimetic allele exhibit absence of cocaine locomotor activity sensitization.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19184 NCBI Gene Model | MGI Sequence Detail 6928 C57BL/6J ±  kb
transcript NM_008950 RefSeq | MGI Sequence Detail 1277 Not Specified  
polypeptide P62196 UniProt | EBI | MGI Sequence Detail 406 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 195
    cDNA 193
    Other 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-32086
References
more
  • Summaries
    All 43
    Developmental Gene Expression 5
    Gene Ontology 12
    Phenotypes 7
  • Earliest
    J:30618 vom Baur E, et al., Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1. EMBO J. 1996 Jan 2;15(1):110-24
  • Latest
    J:260973 Gonzales FR, et al., Proteasome phosphorylation regulates cocaine-induced sensitization. Mol Cell Neurosci. 2018 Apr;88:62-69

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory