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Crybb1
Gene Detail
Symbol

Name
ID
Crybb1
crystallin, beta B1
MGI:104992
Synonyms
3110006K12Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 5
54.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr5:112255815-112269585 bp, + strand
From VEGA annotation of GRCm38

  13771 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1423  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CRYBB1
Protein SuperFamily: beta/gamma crystallins
Gene Tree: Crybb1

Human
homologs
CRYBB1, crystallin, beta B1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1414
neXtProt AC: NX_P53674

Human Synonyms: CATCN3, CTRCT17

Human Chr (Location): 22q12.1; chr22:26599278-26618087 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CRYBB1

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(11)
Incidental mutations (data from CvDC )
Interactions
Crybb1 interacts with 3 markers (Mir1895, Mir1963, Mir3092)
Gene Ontology
(GO)
classifications
All GO classifications: (2 annotations)
Function protein binding, structural constituent of eye lens
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (24)    Tissues (7)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 3
Northern blot 3
RT-PCR 18
cDNA source data(305)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase crybb1 ; ZFIN crybb1    NEW 
Molecular
reagents
All nucleic(309) Genomic(3) cDNA(305) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000024817 (Evidence)
Ensembl Gene Model ENSMUSG00000029343 (Evidence)
Entrez Gene 12960 (Evidence)
UniGene 29488
DFCI TC1572552
DoTS DT.101173221, DT.101738908
Consensus CDS Project CCDS19537.1
International Mouse Phenotyping Consortium Status Crybb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024817 VEGA Gene Model | MGI Sequence Detail 13771 C57BL/6J ±  kb
transcript OTTMUST00000061118 VEGA | MGI Sequence Detail 882 Not Applicable 
polypeptide OTTMUSP00000029911 VEGA | MGI Sequence Detail 250 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(14) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(25 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001064 Beta/gamma crystallin
InterPro IPR011024 Gamma-crystallin-related
Protein Ontology PR:000005911 beta-crystallin B1
References
(Earliest) J:29365 Hulsebos TJ, et al., Assignment of the beta B1 crystallin gene (CRYBB1) to human chromosome 22 and mouse chromosome 5. Genomics. 1995 Oct 10;29(3):712-8
(Latest) J:214344 Kerr CL, et al., AP-2alpha is required after lens vesicle formation to maintain lens integrity. Dev Dyn. 2014 Oct;243(10):1298-309
All references(42)
Other
accession IDs
MGD-MRK-31065, MGI:1920360

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory