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Mxd4
Gene Detail
 Symbol
Name
ID
Mxd4
Max dimerization protein 4
MGI:104991
Synonyms 2810410A03Rik, bHLHc12, Mad4
Feature Type protein coding gene
Genetic Map
Chromosome 5
17.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr5:34173887-34187720 bp, - strand
From VEGA annotation of GRCm38

  13834 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4712  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: MAX interacting protein
Gene Tree: Mxd4

Human
homologs
Human Homolog MXD4, MAX dimerization protein 4
NCBI Gene ID 10608
neXtProt AC  NX_Q14582
Human Synonyms  bHLHc12, MAD4, MST149, MSTP149
Human Chr (Location)  4p16.3; chr4:2247432-2262143 (-)  GRCh38
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process negative regulation of transcription, DNA-templated, regulation of transcription, DNA-templated, ...
Component nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (76)    Tissues (20)    Images (21)
Theiler Stages: 2, 3, 4, 5, 15, 17, 19, 23, 28
Assay TypeResults
RNA in situ 61
RT-PCR 15
cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(14) cDNA(13) Primer pair(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000026714 (Evidence)
Ensembl Gene ModelENSMUSG00000037235 (Evidence)
Entrez Gene17122 (Evidence)
DFCITC1583243, TC1621470, TC1638757
DoTSDT.492662, DT.91568034, DT.94343319, DT.94382623
NIA Mouse Gene IndexU045361, U211515, U360992
Consensus CDS ProjectCCDS19212.1
International Mouse Knockout Project StatusMxd4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026714 VEGA Gene Model | MGI Sequence Detail 13834 C57BL/6J ±  kb
transcript OTTMUST00000066093 VEGA | MGI Sequence Detail 3872 Not Applicable 
polypeptide OTTMUSP00000033054 VEGA | MGI Sequence Detail 209 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000010792 max dimerization protein 4
References (Earliest) J:29949 Hurlin PJ, et al., Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. EMBO J. 1995 Nov 15;14(22):5646-59
(Latest) J:186794 Boros K, et al., The transcription factor Mxd4 controls the proliferation of the first blood precursors at the onset of hematopoietic development in vitro. Exp Hematol. 2011 Nov;39(11):1090-100
All references(38)
Other
accession IDs
MGD-MRK-31064, MGI:1916497

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory