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Mxd4 Gene Detail
Summary
  • Symbol
    Mxd4
  • Name
    Max dimerization protein 4
  • Synonyms
    2810410A03Rik, bHLHc12, Mad4
  • Feature Type
    protein coding gene
  • IDs
    MGI:104991
    NCBI Gene: 17122
  • Gene Overview
    MyGene.info: MXD4
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:34176580-34187710 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 17.84 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    32 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104991
protein coding gene Chr5:34173883-34187720 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029460
protein coding gene Chr5:32382475-32397733 (-)
A/J MGP_AJ_G0029427
protein coding gene Chr5:31328821-31343469 (-)
AKR/J MGP_AKRJ_G0029376
protein coding gene Chr5:32535642-32549461 (-)
BALB/cJ MGP_BALBcJ_G0029437
protein coding gene Chr5:31867867-31881686 (-)
C3H/HeJ MGP_C3HHeJ_G0029159
protein coding gene Chr5:32576309-32590132 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029891
protein coding gene Chr5:34274671-34289299 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027128
protein coding gene Chr5:29105992-29119776 (-)
CAST/EiJ MGP_CASTEiJ_G0028568
protein coding gene Chr5:31643889-31659449 (-)
CBA/J MGP_CBAJ_G0029127
protein coding gene Chr5:35030099-35043955 (-)
DBA/2J MGP_DBA2J_G0029275
protein coding gene Chr5:31502045-31515874 (-)
FVB/NJ MGP_FVBNJ_G0029234
protein coding gene Chr5:30942497-30956514 (-)
LP/J MGP_LPJ_G0029360
protein coding gene Chr5:32806020-32819833 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029264
protein coding gene Chr5:35915653-35930902 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029924
protein coding gene Chr5:32043935-32060531 (-)
PWK/PhJ MGP_PWKPhJ_G0028293
protein coding gene Chr5:30639307-30653159 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028124
protein coding gene Chr5:31492318-31506147 (-)
WSB/EiJ MGP_WSBEiJ_G0028649
protein coding gene Chr5:32119797-32134089 (-)



Homology
more
  • Human Ortholog
    MXD4, MAX dimerization protein 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MXD4, MAX dimerization protein 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bHLHc12, MAD4, MST149, MSTP149
  • Links
    NCBI Gene ID: 10608
    neXtProt AC: NX_Q14582
    UniProt: Q14582

  • Chr Location
    4p16.3; chr4:2247432-2262143 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotype references
  • All Mutations and Alleles
    13
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Radiation induced
    5
  • Spontaneous
    1
  • Targeted
    4
  • Genomic Mutations
    9 involving Mxd4
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 17122 NCBI Gene Model | MGI Sequence Detail 11131 C57BL/6J ±  kb
transcript NM_010753 RefSeq | MGI Sequence Detail 1194 Not Specified  
polypeptide Q60948 UniProt | EBI | MGI Sequence Detail 209 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • InterPro Domains
    IPR036638 Helix-loop-helix DNA-binding domain superfamily
    IPR003327 Leucine zipper, Myc
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Molecular
Reagents
less
  • All nucleic 15
    cDNA 14
    Primer pair 1

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-31064, MGI:1916497
References
more
  • Summaries
    All 54
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 4
    Phenotypes 23
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:186794 Boros K, et al., The transcription factor Mxd4 controls the proliferation of the first blood precursors at the onset of hematopoietic development in vitro. Exp Hematol. 2011 Nov;39(11):1090-100

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory