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Ang2 Gene Detail
Summary
  • Symbol
    Ang2
  • Name
    angiogenin, ribonuclease A family, member 2
  • Synonyms
    Angrp, Rnase5b
  • Feature Type
    protein coding gene
  • IDs
    MGI:104984
    NCBI Gene: 11731
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:51432781-51436400 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 26.42 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    52 from dbSNP Build 142
  • Strain Annotations
    9
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104984
 protein coding gene Chr14:51432781-51436605 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021277
 protein coding gene Chr14:45172729-45173166 (-)
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0021671
 protein coding gene Chr14:47037945-47038382 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0020540
 protein coding gene Chr14:42441148-42444740 (-)
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J MGP_LPJ_G0021179
 protein coding gene Chr14:45627718-45628155 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0021700
 protein coding gene Chr14:44944051-44944488 (-)
PWK/PhJ MGP_PWKPhJ_G0020289
 protein coding gene Chr14:40740434-40740871 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021593
 protein coding gene Chr16:32220111-32220548 (-)
WSB/EiJ MGP_WSBEiJ_G0020592
 protein coding gene Chr14:45167987-45168424 (-)



Homology
more
  • Human Ortholog
    ANG, angiogenin
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANG, angiogenin
  • Synonyms
    ALS9, HEL168, RAA1, RNASE4, RNASE5
  • Links
    NCBI Gene ID: 283
    neXtProt AC: NX_P03950
    UniProt: P03950

  • Chr Location
    14q11.2; chr14:20684177-20698971 (+)  GRCh38
Human Diseases
more
  • Diseases
    6 with human ANG associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    4
  • cDNA Data
    1
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 11731 NCBI Gene Model | MGI Sequence Detail 3620 C57BL/6J ±  kb
transcript NM_007449 RefSeq | MGI Sequence Detail 691 C57BL/6  
polypeptide Q64438 UniProt | EBI | MGI Sequence Detail 145 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 2
    Genomic 1
    cDNA 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-31057
References
more
  • Summaries
    All 48
    Developmental Gene Expression 7
    Gene Ontology 9
    Phenotypes 3
  • Earliest
    J:28832 Brown WE, et al., The mouse angiogenin gene family: structures of an angiogenin-related protein gene and two pseudogenes. Genomics. 1995 Sep 1;29(1):200-6
  • Latest
    J:341637 Lee E, et al., Angiopoietin-2 blockade suppresses growth of liver metastases from pancreatic neuroendocrine tumors by promoting T cell recruitment. J Clin Invest. 2023 Oct 16;133(20)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory