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Cyp7b1
Gene Detail
Symbol

Name
ID
Cyp7b1
cytochrome P450, family 7, subfamily b, polypeptide 1
MGI:104978
Synonyms
D3Ertd552e, hct-1
Feature Type
protein coding gene
Genetic Map
Chromosome 3
4.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:18071950-18243338 bp, - strand
From VEGA annotation of GRCm38

  171389 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3544  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CYP7B1
Protein SuperFamily: cytochrome P450, CYP7A1 type
Gene Tree: Cyp7b1

Human
homologs
CYP7B1, cytochrome P450, family 7, subfamily B, polypeptide 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 9420
neXtProt AC: NX_O75881

Human Synonyms: CBAS3, CP7B, SPG5A

Human Chr (Location): 8q21.3; chr8:64595972-64798791 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human CYP7B1

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele show significantly increased levels of 25- and 27-hydroxycholesterol, and reduced IgA levels. Female mice homozygous for a reporter allele display early onset of puberty and early ovarian failure.
 
Interactions
Cyp7b1 interacts with 104 markers (Mir10a, Mir10b, Mir28b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (9 records)
Data Summary: Results (257)    Tissues (191)    Images (39)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 199
RT-PCR 58
cDNA source data(30)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cyp7b1    NEW 
Molecular
reagents
All nucleic(33) cDNA(30) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000051112 (Evidence)
Ensembl Gene Model ENSMUSG00000039519 (Evidence)
Entrez Gene 13123 (Evidence)
UniGene 316000
DFCI TC1583577, TC1674910
DoTS DT.40175633, DT.94346043, DT.40178557
NIA Mouse Gene Index U023852
EC 1.14.13.100
Consensus CDS Project CCDS17254.1
International Mouse Phenotyping Consortium Status Cyp7b1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051112 VEGA Gene Model | MGI Sequence Detail 171389 C57BL/6J ±  kb
transcript OTTMUST00000129520 VEGA | MGI Sequence Detail 2166 Not Applicable 
polypeptide OTTMUSP00000069551 VEGA | MGI Sequence Detail 507 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(6) UniProt(4)
Polymorphisms
SNPs within 2kb(1138 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1140)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR024204 Cytochrome P450, cholesterol 7-alpha-monooxygenase-type
InterPro IPR002403 Cytochrome P450, E-class, group IV
Protein Ontology PR:000006149 cytochrome P450 7B1
References
(Earliest) J:30123 Stapleton G, et al., A novel cytochrome P450 expressed primarily in brain. J Biol Chem. 1995 Dec 15;270(50):29739-45
(Latest) J:219340 Molyneaux BJ, et al., DeCoN: genome-wide analysis of in vivo transcriptional dynamics during pyramidal neuron fate selection in neocortex. Neuron. 2015 Jan 21;85(2):275-88
All references(58)
Other
accession IDs
MGD-MRK-31051, MGI:1261887, MGI:2139981

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory