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Cyp7b1
Gene Detail
 Symbol
Name
ID
Cyp7b1
cytochrome P450, family 7, subfamily b, polypeptide 1
MGI:104978
Synonyms D3Ertd552e, hct-1
Feature Type protein coding gene
Genetic Map
Chromosome 3
4.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:18071950-18243338 bp, - strand
From NCBI annotation of GRCm38

  171389 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3544  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cytochrome P450, CYP7A1 type
Gene Tree: Cyp7b1

Human
homologs
Human Homolog CYP7B1, cytochrome P450, family 7, subfamily B, polypeptide 1
NCBI Gene ID 9420
neXtProt AC  NX_O75881
Human Synonyms  CBAS3, CP7B, SPG5A
Human Chr (Location)  8q21.3; chr8:64595972-64798791 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human CYP7B1
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele show significantly increased levels of 25- and 27-hydroxycholesterol, and reduced IgA levels. Female mice homozygous for a reporter allele display early onset of puberty and early ovarian failure.
 
Interactions
Cyp7b1 interacts with 105 markers (Mir10a, Mir10b, Mir28b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process bile acid biosynthetic process, cholesterol metabolic process, ...
Component endoplasmic reticulum, intracellular membrane-bounded organelle, ...
Function 25-hydroxycholesterol 7alpha-hydroxylase activity, heme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (257)    Tissues (191)    Images (39)
Theiler Stages: 10, 18, 22, 23, 25, 26, 28
Assay TypeResults
RNA in situ 199
RT-PCR 58
cDNA source data(30)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(33) cDNA(30) Primer pair(3)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000039519 (Evidence)
Entrez Gene13123 (Evidence)
UniGene316000
DFCITC1583577, TC1674910
DoTSDT.40175633, DT.40178557, DT.94346043
NIA Mouse Gene IndexU023852
EC1.14.13.100
Consensus CDS ProjectCCDS17254.1
International Mouse Knockout Project StatusCyp7b1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13123 NCBI Gene Model | MGI Sequence Detail 171389 C57BL/6J ±  kb
transcript NM_007825 RefSeq | MGI Sequence Detail 2166 C57BL/6 
polypeptide Q60991 UniProt | EBI | MGI Sequence Detail 507 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(6) UniProt(4)
Polymorphisms SNPs within 2kb(1138 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1140)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR024204 Cytochrome P450, cholesterol 7-alpha-monooxygenase-type
InterPro IPR002403 Cytochrome P450, E-class, group IV
Protein Ontology PR:000006149 cytochrome P450 7B1
Graphical View of Protein Domain Structure
References (Earliest) J:30123 Stapleton G, et al., A novel cytochrome P450 expressed primarily in brain. J Biol Chem. 1995 Dec 15;270(50):29739-45
(Latest) J:198681 Yi T, et al., EBI2-mediated bridging channel positioning supports splenic dendritic cell homeostasis and particulate antigen capture. Elife. 2013;2:e00757
All references(54)
Other
accession IDs
MGD-MRK-31051, MGI:1261887, MGI:2139981

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory