|Human Homolog||CYP7B1, cytochrome P450, family 7, subfamily B, polypeptide 1|
|NCBI Gene ID||9420|
|Human Synonyms||CBAS3, CP7B, SPG5A|
|Human Chr (Location)||8q21.3; chr8:64595972-64798791 (-) GRCh38|
|Disease Associations||(2) Diseases Associated with Human CYP7B1|
Mice homozygous for a knock-out allele show significantly increased levels of 25- and 27-hydroxycholesterol, and reduced IgA levels. Female mice homozygous for a reporter allele display early onset of puberty and early ovarian failure.
|Process||bile acid biosynthetic process, cholesterol metabolic process, ...|
|Component||endoplasmic reticulum, intracellular membrane-bounded organelle, ...|
|Function||25-hydroxycholesterol 7alpha-hydroxylase activity, heme binding, ...|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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