Cyp7b1
Gene Detail

Symbol Name ID

Cyp7b1 cytochrome P450, family 7, subfamily b, polypeptide 1 MGI:104978

Synonyms

D3Ertd552e, hct-1

Feature Type

protein coding gene

Genetic Map

Chromosome 3

4.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr3:18071950-18243338 bp, - strand From NCBI annotation of GRCm38   171389 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3544  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cytochrome P450, CYP7A1 type
Gene Tree: Cyp7b1

Human homologs

Human Homolog		CYP7B1, cytochrome P450, family 7, subfamily B, polypeptide 1
NCBI Gene ID		9420
neXtProt AC		NX_O75881
Human Synonyms		CBAS3, CP7B, SPG5A
Human Chr (Location)		8q21.3; chr8:65508529-65711348 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human CYP7B1

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for a knock-out allele show significantly increased levels of 25- and 27-hydroxycholesterol, and reduced IgA levels. Female mice homozygous for a reporter allele display early onset of puberty and early ovarian failure.

 

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	bile acid biosynthetic process, cholesterol metabolic process, ...
Component	endoplasmic reticulum, intracellular membrane-bounded organelle, ...
Function	25-hydroxycholesterol 7alpha-hydroxylase activity, electron carrier activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (229)    Tissues (164)    Images (37)
Theiler Stages: 10, 18, 22, 23, 25, 28

Assay Type	Results
RNA in situ	171
RT-PCR	58

cDNA source data(30)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(33) cDNA(30) Primer pair(3)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000039519 (Evidence)
Entrez Gene	13123 (Evidence)
UniGene	316000
DFCI	TC1583577, TC1674910
DoTS	DT.40175633, DT.40178557, DT.94346043
NIA Mouse Gene Index	U023852
EC	1.14.13.100
Consensus CDS Project	CCDS17254.1
International Mouse Knockout Project Status	Cyp7b1

Sequences

Length	Strain/Species
genomic	13123	NCBI Gene Model | MGI Sequence Detail	171389	C57BL/6J
transcript	NM_007825	RefSeq | MGI Sequence Detail	2166	C57BL/6
polypeptide	Q60991	UniProt | EBI | MGI Sequence Detail	507	Not Applicable

All sequences(25) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(661 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001128	Cytochrome P450
InterPro	IPR024204	Cytochrome P450, cholesterol 7-alpha-monooxygenase-type
InterPro	IPR002403	Cytochrome P450, E-class, group IV
Protein Ontology	PR:000006149	cytochrome P450 7B1

Graphical View of Protein Domain Structure

References

(Earliest) J:30123 Stapleton G, et al., A novel cytochrome P450 expressed primarily in brain. J Biol Chem. 1995 Dec 15;270(50):29739-45
(Latest) J:188276 Yi T, et al., Oxysterol Gradient Generation by Lymphoid Stromal Cells Guides Activated B Cell Movement during Humoral Responses. Immunity. 2012 Sep 21;37(3):535-48
All references(52)

Other accession IDs

MGD-MRK-31051, MGI:1261887, MGI:2139981