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Glg1 Gene Detail
Summary
  • Symbol
    Glg1
  • Name
    golgi apparatus protein 1
  • Synonyms
    CFR, CFR-1, ESL-1, MG160, MG-160, Selel
  • Feature Type
    protein coding gene
  • IDs
    MGI:104967
    NCBI Gene: 20340
  • Gene Overview
    MyGene.info: GLG1
Location & Maps
more
  • Sequence Map
    Chr8:111154421-111259216 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      104796 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 57.98 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    GLG1, golgi glycoprotein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GLG1, golgi glycoprotein 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CFR-1, ESL-1, MG160, MG-160
  • Links
    NCBI Gene ID: 2734
    neXtProt AC: NX_Q92896

  • Chr Location
    16q22.3; chr16:74447427-74607144 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 5 alleles in 5 genetic backgrounds
    14 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    22
  • Gene trapped
    19
  • Targeted
    2
  • Transgenic
    1
  • Incidental Mutations
Nullizygous mice show smaller size, narrow rib cages, short and thin bony elements, and reduced chondrocyte proliferation and growth plates. Homozygotes for a gene trap allele show postnatal death, small size, distorted tails and cleft palate. Homozygotes for another gene trap allele die by E10.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036006 VEGA Gene Model | MGI Sequence Detail 104796 C57BL/6J ±  kb
transcript OTTMUST00000092400 VEGA | MGI Sequence Detail 7021 Not Applicable  
polypeptide OTTMUSP00000051057 VEGA | MGI Sequence Detail 1175 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    210 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000008025 Golgi apparatus protein 1
  • InterPro Domains
    IPR001893 Cysteine-rich Golgi apparatus protein 1 repeat
    IPR017873 Cysteine-rich Golgi apparatus protein 1 repeat, eukaryote
Molecular
Reagents
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  • All nucleic 15
    cDNA 14
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-31040, MGI:2142586, MGI:2142794
References
more
  • Summaries
    All 46
    Developmental Gene Expression 6
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:25676 Steegmaier M, et al., The E-selectin-ligand ESL-1 is a variant of a receptor for fibroblast growth factor. Nature. 1995 Feb 16;373(6515):615-20
  • Latest
    J:222703 Pruenster M, et al., Extracellular MRP8/14 is a regulator of beta2 integrin-dependent neutrophil slow rolling and adhesion. Nat Commun. 2015;6:6915

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory