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Npy1r
Gene Detail
 Symbol
Name
ID
Npy1r
neuropeptide Y receptor Y1
MGI:104963
Synonyms Npyr, Y1-R
Feature Type protein coding gene
Genetic Map
Chromosome 8
33.15 cM, cytoband B3-C2
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr8:66697422-66706798 bp, + strand
From NCBI annotation of GRCm38

  9377 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:700  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: neuropeptide Y receptor 1/4/6
Gene Tree: Npy1r

Human
homologs
Human Homolog NPY1R, neuropeptide Y receptor Y1
NCBI Gene ID 4886
neXtProt AC  NX_P25929
Human Synonyms  NPY1-R, NPYR
Human Chr (Location)  4q31.3-q32; chr4:163323964-163344832 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit moderate obesity, mild hyperinsulinemia, reduced activity and energy expenditure, lowered fast-induced refeeding, hyperalgesia, increased neuropathic pain, and resistance to barbiturates.
 
Human Diseases Modeled Using Mouse Npy1r (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Npy1r interacts with 221 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process feeding behavior, glucose metabolic process, ...
Component axon, cytosol, ...
Function G-protein coupled receptor activity, neuropeptide Y receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (66)    Tissues (18)    Images (27)
Theiler Stages: 10, 18, 21, 23, 25, 28
Assay TypeResults
RNA in situ 35
Northern blot 24
RT-PCR 7
cDNA source data(13)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(6) cDNA(14) Primer pair(7) Other(2)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000036437 (Evidence)
Entrez Gene18166 (Evidence)
UniGene5112
DFCITC1591126, TC1593010, TC1716861
DoTSDT.60101014, DT.91400554, DT.94258787
NIA Mouse Gene IndexU009387
Consensus CDS ProjectCCDS22336.1
International Mouse Knockout Project StatusNpy1r
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18166 NCBI Gene Model | MGI Sequence Detail 9377 C57BL/6J ±  kb
transcript NM_010934 RefSeq | MGI Sequence Detail 3007 C57BL/6 
polypeptide Q04573 UniProt | EBI | MGI Sequence Detail 382 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(10) UniProt(2)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(59 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR000351 Neuropeptide Y1 receptor
InterPro IPR000611 Neuropeptide Y receptor family
Protein Ontology PR:000001622 neuropeptide Y receptor type 1
Graphical View of Protein Domain Structure
References (Earliest) J:3466 Eva C, et al., The murine NPY-1 receptor gene. Structure and delineation of tissue-specific expression. FEBS Lett. 1992 Dec 21;314(3):285-8
(Latest) J:208015 Xiang J, et al., Huntingtin-associated protein 1 regulates postnatal neurogenesis and neurotrophin receptor sorting. J Clin Invest. 2014 Jan 2;124(1):85-98
All references(93)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-12929, MGD-MRK-31036

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory