Npy1r
Gene Detail

Symbol Name ID

Npy1r neuropeptide Y receptor Y1 MGI:104963

Synonyms

Npyr, Y1-R

Feature Type

protein coding gene

Genetic Map

Chromosome 8

33.15 cM, cytoband B3-C2
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr8:66697422-66706798 bp, + strand From NCBI annotation of GRCm38   9377 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:700  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: neuropeptide Y receptor 1/4/6
Gene Tree: Npy1r

Human homologs

Human Homolog		NPY1R, neuropeptide Y receptor Y1
NCBI Gene ID		4886
neXtProt AC		NX_P25929
Human Synonyms		NPY1-R, NPYR
Human Chr (Location)		4q31.3-q32; chr4:164245117-164253947 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(9) : Targeted(9)
 

Homozygotes for targeted null mutations exhibit moderate obesity, mild hyperinsulinemia, reduced activity and energy expenditure, lowered fast-induced refeeding, hyperalgesia, increased neuropathic pain, and resistance to barbiturates.

 
Human Diseases Modeled Using Mouse Npy1r (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	feeding behavior, glucose metabolic process, ...
Component	axon, cytosol, ...
Function	G-protein coupled receptor activity, neuropeptide Y receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (66)    Tissues (18)    Images (27)
Theiler Stages: 10, 18, 21, 23, 25, 28

Assay Type	Results
RNA in situ	35
Northern blot	24
RT-PCR	7

cDNA source data(13)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(29) Genomic(6) cDNA(14) Primer pair(7) Other(2)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000036437 (Evidence)
Entrez Gene	18166 (Evidence)
UniGene	5112
DFCI	TC1591126, TC1593010, TC1716861
DoTS	DT.60101014, DT.91400554, DT.94258787
NIA Mouse Gene Index	U009387
Consensus CDS Project	CCDS22336.1
International Mouse Knockout Project Status	Npy1r

Sequences

Length	Strain/Species
genomic	18166	NCBI Gene Model | MGI Sequence Detail	9377	C57BL/6J
transcript	NM_010934	RefSeq | MGI Sequence Detail	3007	C57BL/6
polypeptide	Q04573	UniProt | EBI | MGI Sequence Detail	382	Not Applicable

All sequences(24) RefSeq(2) UniProt(2)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(53 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000351	Neuropeptide Y1 receptor
InterPro	IPR000611	Neuropeptide Y receptor
Protein Ontology	PR:000001622	neuropeptide Y receptor 1

Graphical View of Protein Domain Structure

References

(Earliest) J:3466 Eva C, et al., The murine NPY-1 receptor gene. Structure and delineation of tissue-specific expression. FEBS Lett. 1992 Dec 21;314(3):285-8
(Latest) J:192723 Pjetri E, et al., NPY receptor subtype specification for behavioral adaptive strategies during limited food access. Genes Brain Behav. 2012 Feb;11(1):105-12
All references(89)

Other accession IDs

MGD-MRK-12929, MGD-MRK-31036