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Npy1r Gene Detail
Summary
  • Symbol
    Npy1r
  • Name
    neuropeptide Y receptor Y1
  • Synonyms
    Npyr, Y1-R
  • Feature Type
    protein coding gene
  • IDs
    MGI:104963
    NCBI Gene: 18166
  • Gene Overview
    MyGene.info: NPY1R
Location & Maps
more
  • Sequence Map
    Chr8:66697422-66706798 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9377 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 33.15 cM, cytoband B3-C2
  • Mapping Data
    12 experiments
Homology
more
  • Human Ortholog
    NPY1R, neuropeptide Y receptor Y1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NPY1R, neuropeptide Y receptor Y1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NPY1-R, NPYR
  • Links
    NCBI Gene ID: 4886
    neXtProt AC: NX_P25929

  • Chr Location
    4q32.2; chr4:163323962-163344832 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Npy1r mouse models

Human Disease Mouse Models
       Obesity   OMIM: 601665 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    89 phenotypes from 7 alleles in 8 genetic backgrounds
    16 phenotypes from multigenic genotypes
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Targeted
    11
  • Genomic Mutations
    2 involving Npy1r
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit moderate obesity, mild hyperinsulinemia, reduced activity and energy expenditure, lowered fast-induced refeeding, hyperalgesia, increased neuropathic pain, and resistance to barbiturates.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036437 Ensembl Gene Model | MGI Sequence Detail 9377 C57BL/6J ±  kb
transcript ENSMUST00000039303 Ensembl | MGI Sequence Detail 3007 Not Applicable  
polypeptide ENSMUSP00000045530 Ensembl | MGI Sequence Detail 382 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    59 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001622 neuropeptide Y receptor type 1
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR000351 Neuropeptide Y1 receptor
    IPR000611 Neuropeptide Y receptor family
Molecular
Reagents
less
  • All nucleic 29
    Genomic 6
    cDNA 14
    Primer pair 7
    Other 2

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-12929, MGD-MRK-31036
References
more
  • Summaries
    All 94
    Developmental Gene Expression 8
    Diseases 1
    Gene Ontology 9
    Phenotypes 50
  • Earliest
    J:3466 Eva C, et al., The murine NPY-1 receptor gene. Structure and delineation of tissue-specific expression. FEBS Lett. 1992 Dec 21;314(3):285-8
  • Latest
    J:222788 Park MH, et al., Neuropeptide Y regulates the hematopoietic stem cell microenvironment and prevents nerve injury in the bone marrow. EMBO J. 2015 Jun 12;34(12):1648-60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory