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Tnfaip1 Gene Detail
Summary
  • Symbol
    Tnfaip1
  • Name
    tumor necrosis factor, alpha-induced protein 1 (endothelial)
  • Synonyms
    Bacurd2, Edp1, Edp-1, Tnfip1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104961
    NCBI Gene: 21927
  • Gene Overview
    MyGene.info: TNFAIP1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:78522850-78536260 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 46.74 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    17 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104961
protein coding gene Chr11:78522850-78536332 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018786
protein coding gene Chr11:79542633-79556199 (-)
A/J MGP_AJ_G0018752
protein coding gene Chr11:76495440-76508949 (-)
AKR/J MGP_AKRJ_G0018722
protein coding gene Chr11:78799888-78813384 (-)
BALB/cJ MGP_BALBcJ_G0018726
protein coding gene Chr11:76897234-76910682 (-)
C3H/HeJ MGP_C3HHeJ_G0018539
protein coding gene Chr11:78846387-78861400 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019177
protein coding gene Chr11:82011503-82025031 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016812
protein coding gene Chr11:73464071-73477178 (-)
CAST/EiJ MGP_CASTEiJ_G0018093
protein coding gene Chr11:79303526-79315246 (-)
CBA/J MGP_CBAJ_G0018510
protein coding gene Chr11:85624640-85640479 (-)
DBA/2J MGP_DBA2J_G0018618
protein coding gene Chr11:76068792-76081950 (-)
FVB/NJ MGP_FVBNJ_G0018608
protein coding gene Chr11:75658792-75672865 (-)
LP/J MGP_LPJ_G0018689
protein coding gene Chr11:80056803-80069981 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018634
protein coding gene Chr11:85983953-85997497 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019217
protein coding gene Chr11:79048181-79061659 (-)
PWK/PhJ MGP_PWKPhJ_G0017864
protein coding gene Chr11:76865243-76878521 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017655
protein coding gene Chr11:78663111-78676280 (-)
WSB/EiJ MGP_WSBEiJ_G0018146
protein coding gene Chr11:78878466-78892009 (-)



Homology
more
  • Human Ortholog
    TNFAIP1, TNF alpha induced protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TNFAIP1, TNF alpha induced protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    B12, B61, BTBD34, EDP1, hBACURD2
  • Links
    NCBI Gene ID: 7126
    neXtProt AC: NX_Q13829
    UniProt: Q13829

  • Chr Location
    17q11.2; chr17:28335522-28347009 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21927 NCBI Gene Model | MGI Sequence Detail 13411 C57BL/6J ±  kb
    transcript NM_009395 RefSeq | MGI Sequence Detail 3709 C57BL/6  
    polypeptide O70479 UniProt | EBI | MGI Sequence Detail 316 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000016472 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
    • InterPro Domains
      IPR000210 BTB/POZ domain
      IPR003131 Potassium channel tetramerisation-type BTB domain
      IPR011333 SKP1/BTB/POZ domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 6
      cDNA 18
      Primer pair 1
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-19447, MGD-MRK-31034, MGD-MRK-9301, MGD-MRK-9302
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 17
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:231580 Gladwyn-Ng I, et al., Bacurd1/Kctd13 and Bacurd2/Tnfaip1 are interacting partners to Rnd proteins which influence the long-term positioning and dendritic maturation of cerebral cortical neurons. Neural Dev. 2016;11:7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory