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Tnfaip1
Gene Detail
 Symbol
Name
ID
Tnfaip1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
MGI:104961
Synonyms Edp1, Edp-1, Tnfaip1, Tnfip1
Feature Type protein coding gene
Genetic Map
Chromosome 11
46.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr11:78522850-78536332 bp, - strand
From VEGA annotation of GRCm38

  13483 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22519  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Tnfaip1

Human
homologs
Human Homolog TNFAIP1, tumor necrosis factor, alpha-induced protein 1 (endothelial)
NCBI Gene ID 7126
neXtProt AC  NX_Q13829
Human Synonyms  B12, B61, BTBD34, EDP1, hBACURD2
Human Chr (Location)  17q22-q23; chr17:28335522-28347009 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(11) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Tnfaip1 interacts with 321 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cell migration, DNA replication, ...
Component Cul3-RING ubiquitin ligase complex, cytoplasm, ...
Function GTP-Rho binding, protein domain specific binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (139)    Tissues (18)    Images (22)
Theiler Stages: 23
Assay TypeResults
RNA in situ 139
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) Genomic(6) cDNA(17) Primer pair(1) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000000144 (Evidence)
Ensembl Gene ModelENSMUSG00000017615 (Evidence)
Entrez Gene21927 (Evidence)
DFCITC1571867, TC1622543, TC1678087, TC1693289
DoTSDT.493879, DT.94351652, DT.94351675, DT.97348093, DT.99854811
NIA Mouse Gene IndexU033134
Consensus CDS ProjectCCDS25110.1
International Mouse Knockout Project StatusTnfaip1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000144 VEGA Gene Model | MGI Sequence Detail 13483 C57BL/6J ±  kb
transcript OTTMUST00000000463 VEGA | MGI Sequence Detail 3720 Not Applicable 
polypeptide OTTMUSP00000000200 VEGA | MGI Sequence Detail 316 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(6) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(17 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR003131 Potassium channel tetramerisation-type BTB domain
Protein Ontology PR:000016472 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
References (Earliest) J:11410 Buckwalter MS, et al., Localization of the panhypopituitary dwarf mutation (df) on mouse chromosome 11 in an intersubspecific backcross. Genomics. 1991 Jul;10(3):515-26
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(48)
Other
accession IDs
MGD-MRK-19447, MGD-MRK-31034, MGD-MRK-9301, MGD-MRK-9302

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory