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Tnfaip1 Gene Detail
Summary
  • Symbol
    Tnfaip1
  • Name
    tumor necrosis factor, alpha-induced protein 1 (endothelial)
  • Synonyms
    Bacurd2, Edp1, Edp-1, Tnfip1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104961
    NCBI Gene: 21927
  • Gene Overview
    MyGene.info: TNFAIP1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:78522850-78536332 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13483 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 46.74 cM
  • Mapping Data
    13 experiments
Homology
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  • Human Ortholog
    TNFAIP1, TNF alpha induced protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TNFAIP1, TNF alpha induced protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    B12, B61, BTBD34, EDP1, hBACURD2
  • Links
    NCBI Gene ID: 7126
    neXtProt AC: NX_Q13829
    UniProt: Q13829

  • Chr Location
    17q11.2; chr17:28335522-28347009 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000144 VEGA Gene Model | MGI Sequence Detail 13483 C57BL/6J ±  kb
transcript OTTMUST00000000463 VEGA | MGI Sequence Detail 3720 Not Applicable  
polypeptide OTTMUSP00000000200 VEGA | MGI Sequence Detail 316 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    17 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000016472 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
  • InterPro Domains
    IPR000210 BTB/POZ domain
    IPR003131 Potassium channel tetramerisation-type BTB domain
    IPR011333 SKP1/BTB/POZ domain superfamily
Molecular
Reagents
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  • All nucleic 25
    Genomic 6
    cDNA 17
    Primer pair 1
    Other 1

    Microarray probesets 8
Other
Accession IDs
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MGD-MRK-19447, MGD-MRK-31034, MGD-MRK-9301, MGD-MRK-9302
References
more
  • Summaries
    All 54
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 17
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:231580 Gladwyn-Ng I, et al., Bacurd1/Kctd13 and Bacurd2/Tnfaip1 are interacting partners to Rnd proteins which influence the long-term positioning and dendritic maturation of cerebral cortical neurons. Neural Dev. 2016;11:7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory