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Tnfaip1
Gene Detail
Symbol

Name
ID
Tnfaip1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
MGI:104961
Synonyms
Edp1, Edp-1, Tnfaip1, Tnfip1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
46.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr11:78522850-78536332 bp, - strand
From VEGA annotation of GRCm38

  13483 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22519  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TNFAIP1
Gene Tree: Tnfaip1

Human
homologs
TNFAIP1, tumor necrosis factor, alpha-induced protein 1 (endothelial)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7126
neXtProt AC: NX_Q13829

Human Synonyms: B12, B61, BTBD34, EDP1, hBACURD2

Human Chr (Location): 17q22-q23; chr17:28335522-28347009 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(11) Targeted(5)
Genomic Mutations involving Tnfaip1 (1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Tnfaip1 interacts with 321 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cell migration, DNA replication, ...
Component Cul3-RING ubiquitin ligase complex, cytoplasm, ...
Function GTP-Rho binding, protein domain specific binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (139)    Tissues (18)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 139
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tnfaip1    NEW 
Molecular
reagents
All nucleic(25) Genomic(6) cDNA(17) Primer pair(1) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000000144 (Evidence)
Ensembl Gene Model ENSMUSG00000017615 (Evidence)
Entrez Gene 21927 (Evidence)
DFCI TC1678087, TC1622543, TC1571867, TC1693289
DoTS DT.97348093, DT.94351675, DT.94351652, DT.493879, DT.99854811
NIA Mouse Gene Index U033134
Consensus CDS Project CCDS25110.1
International Mouse Phenotyping Consortium Status Tnfaip1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000144 VEGA Gene Model | MGI Sequence Detail 13483 C57BL/6J ±  kb
transcript OTTMUST00000000463 VEGA | MGI Sequence Detail 3720 Not Applicable 
polypeptide OTTMUSP00000000200 VEGA | MGI Sequence Detail 316 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(17 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR003131 Potassium channel tetramerisation-type BTB domain
Protein Ontology PR:000016472 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
References
(Earliest) J:11410 Buckwalter MS, et al., Localization of the panhypopituitary dwarf mutation (df) on mouse chromosome 11 in an intersubspecific backcross. Genomics. 1991 Jul;10(3):515-26
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(47)
Other
accession IDs
MGD-MRK-19447, MGD-MRK-31034, MGD-MRK-9301, MGD-MRK-9302

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory