Abi1
Gene Detail

Symbol Name ID

Abi1 abl-interactor 1 MGI:104913

Synonyms

E3B1, Ssh3bp1

Feature Type

protein coding gene

Genetic Map

Chromosome 2

15.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr2:22940073-23040241 bp, - strand From VEGA annotation of GRCm38   100169 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:38053  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Abi1

Human homologs

Human Homolog		ABI1, abl-interactor 1
NCBI Gene ID		10006
neXtProt AC		NX_Q8IZP0
Human Synonyms		ABI-1, ABLBP4, E3B1, NAP1BP, SSH3BP, SSH3BP1
Human Chr (Location)		10p11.2; chr10:26746596-26861087 (-)  GRCh38

Alleles and phenotypes

All alleles(96) : Gene trapped(91) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a knock-out allele exhibit background sensitive embryonic lethality prior during organogenesis associated with about abnormal vasculogenesis and angiogenesis.

 

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	cellular component movement, cellular process, ...
Component	cell junction, cell leading edge, ...
Function	protein binding, protein complex binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)

Data Summary: Results (98)    Tissues (47)    Images (9)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	6
RT-PCR	92

cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) cDNA(18) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000016621 (Evidence)
Ensembl Gene Model	ENSMUSG00000058835 (Evidence)
Entrez Gene	11308 (Evidence)
DoTS	DT.101216599, DT.101399232, DT.101399237, DT.110723925, DT.110723947, DT.111132759, DT.94267453
NIA Mouse Gene Index	U022352
Consensus CDS Project	CCDS38058.1, CCDS38059.1, CCDS38060.1, CCDS38061.1, CCDS50513.1
International Mouse Knockout Project Status	Abi1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016621	VEGA Gene Model | MGI Sequence Detail	100169	C57BL/6J
transcript	OTTMUST00000083345	VEGA | MGI Sequence Detail	3067	Not Applicable
polypeptide	OTTMUSP00000044764	VEGA | MGI Sequence Detail	481	Not Applicable

All sequences(128) RefSeq(18) UniProt(13)

Polymorphisms

PCR(1) : SNPs within 2kb(172 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR012849	Abl-interactor, homeo-domain homologous domain
InterPro	IPR001452	Src homology-3 domain
InterPro	IPR000727	Target SNARE coiled-coil domain
Protein Ontology	PR:000003578	abl interactor 1

References

(Earliest) J:29673 Shi Y, et al., Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activity. Genes Dev. 1995 Nov 1;9(21):2583-97
(Latest) J:184110 Verpelli C, et al., Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. J Biol Chem. 2011 Oct 7;286(40):34839-50
All references(56)

Other accession IDs

MGD-MRK-29067