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Abi1
Gene Detail
Symbol

Name
ID
Abi1
abl-interactor 1
MGI:104913
Synonyms
E3B1, Ssh3bp1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
15.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:22940073-23040241 bp, - strand
From VEGA annotation of GRCm38

  100169 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38053  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Abi1

Human
homologs
Human Homolog ABI1, abl-interactor 1
NCBI Gene ID 10006
neXtProt AC  NX_Q8IZP0
Human Synonyms  ABI-1, ABLBP4, E3B1, NAP1BP, SSH3BP, SSH3BP1
Human Chr (Location)  10p11.2; chr10:26746596-26861087 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(96) : Gene trapped(91) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit background sensitive embryonic lethality prior during organogenesis associated with about abnormal vasculogenesis and angiogenesis.
 
Interactions
Abi1 interacts with 339 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process cellular component movement, cellular process, ...
Component cell junction, cell leading edge, ...
Function protein binding, protein complex binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (98)    Tissues (48)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 6
RT-PCR 92
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(18) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016621 (Evidence)
Ensembl Gene ModelENSMUSG00000058835 (Evidence)
Entrez Gene11308 (Evidence)
DoTSDT.101216599, DT.110723925, DT.101399237, DT.101399232, DT.110723947, DT.94267453, DT.111132759
NIA Mouse Gene IndexU022352
Consensus CDS ProjectCCDS38058.1, CCDS38059.1, CCDS38060.1, CCDS38061.1, CCDS50513.1
International Mouse Knockout Project StatusAbi1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016621 VEGA Gene Model | MGI Sequence Detail 100169 C57BL/6J ±  kb
transcript OTTMUST00000083345 VEGA | MGI Sequence Detail 3067 Not Applicable 
polypeptide OTTMUSP00000044764 VEGA | MGI Sequence Detail 481 Not Applicable 

For the selected sequences
All sequences(140) RefSeq(18) UniProt(25)
Polymorphisms
PCR(1) : SNPs within 2kb(172 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012849 Abl-interactor, homeo-domain homologous domain
InterPro IPR001452 Src homology-3 domain
InterPro IPR000727 Target SNARE coiled-coil domain
Protein Ontology PR:000003578 abl interactor 1
References
(Earliest) J:29673 Shi Y, et al., Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activity. Genes Dev. 1995 Nov 1;9(21):2583-97
(Latest) J:184110 Verpelli C, et al., Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. J Biol Chem. 2011 Oct 7;286(40):34839-50
All references(56)
Other
accession IDs
MGD-MRK-29067

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory