Abi1 MGI Mouse Gene Detail - MGI:104913

Abi1 Gene Detail

Symbol

Abi1
Name

abl-interactor 1
Synonyms

E3B1, Ssh3bp1

Feature Type

protein coding gene
IDs

MGI:104913
NCBI Gene: 11308
Gene Overview

MyGene.info: ABI1

Sequence Map

Chr2:22940073-23040241 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

100169 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 15.18 cM
Mapping Data

4 experiments

Human Ortholog

ABI1, abl interactor 1

Vertebrate Orthologs

8

Human Ortholog

ABI1, abl interactor 1
Orthology source: HomoloGene, HGNC
Synonyms

ABI-1, ABLBP4, E3B1, NAP1BP, SSH3BP, SSH3BP1
Links

HGNC:11320

NCBI Gene ID: 10006

neXtProt AC: NX_Q8IZP0
Chr Location

10p11.2; chr10:26746596-26861087 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 38053
1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: ABI1
Gene Tree

Abi1

less

Phenotype Summary

22 phenotypes from 2 alleles in 4 genetic backgrounds
4 phenotypes from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

96
Gene trapped

91
Targeted

5
Incidental Mutations

Mutagenetix , APF

Mice homozygous for a knock-out allele exhibit background sensitive embryonic lethality prior during organogenesis associated with about abnormal vasculogenesis and angiogenesis.

less

All GO Annotations

34
GO References

14

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

98
Tissues

48
cDNA Data

17
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase abi1

ZFIN abi1a

less

Abi1 interacts with 339 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

less

All Sequences

127
RefSeq

18
UniProt

13
CCDS

CCDS38058.1, CCDS38059.1, CCDS38060.1, CCDS38061.1, CCDS50513.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000016621	VEGA Gene Model \| MGI Sequence Detail	100169	C57BL/6J	± kb
transcript	OTTMUST00000083345	VEGA \| MGI Sequence Detail	3067	Not Applicable
polypeptide	OTTMUSP00000044764	VEGA \| MGI Sequence Detail	481	Not Applicable

less

SNPs within 2kb

167 from dbSNP Build 142

PCR

1

less

UniProt

13 Sequences
Protein Ontology

PR:000003578 abl interactor 1
InterPro Domains

IPR028457 ABI family

IPR028456 Abl interactor 1

IPR012849 Abl-interactor, homeo-domain homologous domain

IPR001452 SH3 domain

IPR000727 Target SNARE coiled-coil homology domain

less

All nucleic 20

cDNA 18

Primer pair 2

Microarray probesets 3

less

MGD-MRK-29067

Summaries

All 54

Developmental Gene Expression 5

Gene Ontology 14

Phenotypes 12
Earliest

J:29673 Shi Y, et al., Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activity. Genes Dev. 1995 Nov 1;9(21):2583-97
Latest

J:216588 Jia JM, et al., The schizophrenia susceptibility gene dysbindin regulates dendritic spine dynamics. J Neurosci. 2014 Oct 8;34(41):13725-36

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 09/27/2016 MGI 6.05