Abi1 MGI Mouse Gene Detail - MGI:104913

Symbol

Abi1
Name

abl-interactor 1
Synonyms

E3B1, Ssh3bp1

Feature Type

protein coding gene
IDs

MGI:104913
NCBI Gene: 11308
Gene Overview

MyGene.info: ABI1
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:22940073-23040241 bp, - strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 15.18 cM
Mapping Data

4 experiments

SNPs within 2kb

167 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104913	protein coding gene	Chr2:22939989-23040241 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025394	protein coding gene	Chr2:20678220-20781318 (-)
A/J	MGP_AJ_G0025372	protein coding gene	Chr2:19834422-19942591 (-)
AKR/J	MGP_AKRJ_G0025341	protein coding gene	Chr2:20549161-20650246 (-)
BALB/cJ	MGP_BALBcJ_G0025367	protein coding gene	Chr2:19952016-20049892 (-)
C3H/HeJ	MGP_C3HHeJ_G0025128	protein coding gene	Chr2:20450373-20550642 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025811	protein coding gene	Chr2:21277199-21378051 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023225	protein coding gene	Chr2:18926460-19019034 (-)
CAST/EiJ	MGP_CASTEiJ_G0024591	protein coding gene	Chr2:20375697-20480101 (-)
CBA/J	MGP_CBAJ_G0025106	protein coding gene	Chr2:22090070-22203444 (-)
DBA/2J	MGP_DBA2J_G0025239	protein coding gene	Chr2:19736358-19832685 (-)
FVB/NJ	MGP_FVBNJ_G0025201	protein coding gene	Chr2:19521001-19617169 (-)
LP/J	MGP_LPJ_G0025325	protein coding gene	Chr2:20610146-20711582 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025232	protein coding gene	Chr2:22131627-22240746 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025870	protein coding gene	Chr2:20430768-20543869 (-)
PWK/PhJ	MGP_PWKPhJ_G0024340	protein coding gene	Chr2:19558079-19655307 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024140	protein coding gene	Chr2:20556785-20822943 (-)
WSB/EiJ	MGP_WSBEiJ_G0024661	protein coding gene	Chr2:20573097-20673584 (-)

Human Ortholog

ABI1, abl interactor 1

Vertebrate Orthologs

8

Human Ortholog

ABI1, abl interactor 1
Orthology source: HomoloGene, HGNC
Synonyms

ABI-1, ABLBP4, E3B1, NAP1BP, SSH3BP, SSH3BP1
Links

HGNC:11320

NCBI Gene ID: 10006

neXtProt AC: NX_Q8IZP0

UniProt: Q8IZP0
Chr Location

10p12.1; chr10:26746596-26861087 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 38053
1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: ABI1
Gene Tree

Abi1

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Phenotype Summary

22 phenotypes from 2 alleles in 4 genetic backgrounds
4 phenotypes from multigenic genotypes
1 images
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

96
Gene trapped

91
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

72 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit background sensitive embryonic lethality prior during organogenesis associated with about abnormal vasculogenesis and angiogenesis.

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All GO Annotations

38
GO References

21

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

98
Tissues

48
cDNA Data

18
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase abi1

ZFIN abi1a

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Abi1 interacts with 339 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

119
RefSeq

18
UniProt

13
CCDS

CCDS38058.1, CCDS38059.1, CCDS38060.1, CCDS38061.1, CCDS50513.1, CCDS84479.1, CCDS84480.1, CCDS84481.1

Ensembl

ENSMUSG00000058835 (Evidence)
NCBI Gene

11308

			Length	Strain/Species	Flank
genomic	ENSMUSG00000058835	Ensembl Gene Model \| MGI Sequence Detail	100169	C57BL/6J	± kb
transcript	ENSMUST00000123948	Ensembl \| MGI Sequence Detail	3067	Not Applicable
polypeptide	ENSMUSP00000118491	Ensembl \| MGI Sequence Detail	481	Not Applicable

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UniProt

13 Sequences
Protein Ontology

PR:000003578 abl interactor 1

(term hierarchy)
InterPro Domains

IPR028457 ABI family

IPR028456 Abl interactor 1

IPR035725 Abl Interactor 1, SH3 domain

IPR012849 Abl-interactor, homeo-domain homologous domain

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

IPR000727 Target SNARE coiled-coil homology domain

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All nucleic 21

cDNA 19

Primer pair 2

Microarray probesets 3

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MGD-MRK-29067

Summaries

All 63

Developmental Gene Expression 6

Gene Ontology 21

Phenotypes 12
Earliest

J:29673 Shi Y, et al., Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activity. Genes Dev. 1995 Nov 1;9(21):2583-97
Latest

J:236302 Zhang X, et al., Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex. Cell. 2016 Aug 25;166(5):1147-1162.e15

TSS for Abi1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr22889	Chr2:23040177-23040201 (-)	52 bp
Tssr22888	Chr2:23040138-23040174 (-)	85 bp
Tssr22887	Chr2:23040092-23040127 (-)	131 bp
Tssr22878	Chr2:22960836-22960856 (-)	79,395 bp
Tssr22877	Chr2:22953534-22953567 (-)	86,690 bp
Tssr22876	Chr2:22950688-22950707 (-)	89,543 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 11/13/2018 MGI 6.13