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Tead2 Gene Detail
Summary
  • Symbol
    Tead2
  • Name
    TEA domain family member 2
  • Synonyms
    Etdf, TEAD-2, TEF-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:104904
    NCBI Gene: 21677
Location & Maps
more
  • Sequence Map
    Chr7:45215753-45233635 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17883 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TEAD2, TEA domain transcription factor 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TEAD2, TEA domain transcription factor 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ETF, TEAD-2, TEF4, TEF-4
  • Links
    NCBI Gene ID: 8463
    neXtProt AC: NX_Q15562

  • Chr Location
    19q13.3; chr19:49340595-49362457 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    29 phenotypes from multigenic genotypes
    2 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a functionally null allele of this gene exhibit no gross abnormalities and are fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025380 VEGA Gene Model | MGI Sequence Detail 17883 C57BL/6J ±  kb
transcript OTTMUST00000062478 VEGA | MGI Sequence Detail 2115 Not Applicable  
polypeptide OTTMUSP00000030804 VEGA | MGI Sequence Detail 445 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    136 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    7 Sequences
  • InterPro Domains
    IPR000818 TEA/ATTS
    IPR016361 Transcriptional enhancer factor, metazoa
Molecular
Reagents
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  • All nucleic 29
    Genomic 3
    cDNA 22
    Primer pair 3
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-29058
References
more
  • Summaries
    All 62
    Developmental Gene Expression 27
    Gene Ontology 12
    Phenotypes 10
  • Earliest
    J:48110 Burglin TR, The TEA domain: a novel, highly conserved DNA-binding motif [letter]. Cell. 1991 Jul 12;66(1):11-2
  • Latest
    J:224392 Poncy A, et al., Transcription factors SOX4 and SOX9 cooperatively control development of bile ducts. Dev Biol. 2015 Aug 15;404(2):136-48

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory