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Gpc4 Gene Detail
Summary
  • Symbol
    Gpc4
  • Name
    glypican 4
  • Synonyms
    9530073D23Rik, K-glypican
  • Feature Type
    protein coding gene
  • IDs
    MGI:104902
    NCBI Gene: 14735
  • Gene Overview
    MyGene.info: GPC4
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:52053021-52165252 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 28.33 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    410 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104902
protein coding gene ChrX:52050885-52165252 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035715
protein coding gene ChrX:47250054-47366966 (-)
A/J MGP_AJ_G0035698
protein coding gene ChrX:47106298-47230274 (-)
AKR/J MGP_AKRJ_G0035618
protein coding gene ChrX:48404580-48521353 (-)
BALB/cJ MGP_BALBcJ_G0035684
protein coding gene ChrX:46658039-46770459 (-)
C3H/HeJ MGP_C3HHeJ_G0035388
protein coding gene ChrX:47499399-47614839 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036214
protein coding gene ChrX:48363969-48484076 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033065
protein coding gene ChrX:44580375-44692994 (-)
CAST/EiJ MGP_CASTEiJ_G0034679
protein coding gene ChrX:34944499-35062772 (-)
CBA/J MGP_CBAJ_G0035362
protein coding gene ChrX:49707924-49828918 (-)
DBA/2J MGP_DBA2J_G0035517
protein coding gene ChrX:46907829-47020770 (-)
FVB/NJ MGP_FVBNJ_G0035465
protein coding gene ChrX:46615139-46728051 (-)
LP/J MGP_LPJ_G0035604
protein coding gene ChrX:47558345-47676372 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035504
protein coding gene ChrX:51278320-51398145 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036231
protein coding gene ChrX:47129599-47243905 (-)
PWK/PhJ MGP_PWKPhJ_G0034378
protein coding gene ChrX:34433729-34548899 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034223
protein coding gene ChrX:35732284-35845353 (-)
WSB/EiJ MGP_WSBEiJ_G0034823
protein coding gene ChrX:46691677-46809116 (-)



Homology
more
  • Human Ortholog
    GPC4, glypican 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GPC4, glypican 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    K-glypican
  • Links
    NCBI Gene ID: 2239
    neXtProt AC: NX_O75487
    UniProt: O75487

  • Chr Location
    Xq26.2; chrX:133301036-133415177 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 55582
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GPC4
  • Protein SuperFamily
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human GPC4 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Male mice hemizygous for a null allele exhibit signs of anemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031119 Ensembl Gene Model | MGI Sequence Detail 112232 C57BL/6J ±  kb
transcript ENSMUST00000033450 Ensembl | MGI Sequence Detail 2651 Not Applicable  
polypeptide ENSMUSP00000033450 Ensembl | MGI Sequence Detail 557 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 28
    cDNA 23
    Primer pair 5

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-29056, MGI:1925872, MGI:2147881, MGI:2147905, MGI:2152785
References
more
  • Summaries
    All 69
    Developmental Gene Expression 14
    Gene Ontology 8
    Phenotypes 15
  • Earliest
    J:59268 Williams BO, et al., Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences. EMBO J. 1994 Sep 15;13(18):4251-9
  • Latest
    J:264113 Lopez-Escobar B, et al., The non-canonical Wnt-PCP pathway shapes the mouse caudal neural plate. Development. 2018 May 8;145(9)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory