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Gpc4
Gene Detail
Symbol

Name
ID
Gpc4
glypican 4
MGI:104902
Synonyms
9530073D23Rik, K-glypican
Feature Type
protein coding gene
Genetic Map
Chromosome X
28.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
ChrX:52053021-52165252 bp, - strand
From VEGA annotation of GRCm38

  112232 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55582  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GPC4
Protein SuperFamily: glypican
Gene Tree: Gpc4

Human
homologs
GPC4, glypican 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2239
neXtProt AC: NX_O75487

Human Synonyms: K-glypican

Human Chr (Location): Xq26.1; chrX:133301036-133415177 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human GPC4

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(10) Targeted(6)
Incidental mutations (data from APF , CvDC )
Interactions
Gpc4 interacts with 134 markers (Mir7-1, Mir17, Mir20a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Component anchored component of membrane, external side of plasma membrane, ...
Function heparan sulfate proteoglycan binding
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (470)    Tissues (108)    Images (73)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 460
Western blot 3
RT-PCR 1
cDNA source data(21)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA GPC4 ; Xenbase gpc4 ; ZFIN gpc4    NEW 
Molecular
reagents
All nucleic(25) cDNA(21) Primer pair(4)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000017330 (Evidence)
Ensembl Gene Model ENSMUSG00000031119 (Evidence)
Entrez Gene 14735 (Evidence)
DFCI TC1581967, TC1620737
DoTS DT.101185035, DT.111022063, DT.526694
NIA Mouse Gene Index U039381, U260239
Consensus CDS Project CCDS30124.1
International Mouse Phenotyping Consortium Status Gpc4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017330 VEGA Gene Model | MGI Sequence Detail 112232 C57BL/6J ±  kb
transcript OTTMUST00000042112 VEGA | MGI Sequence Detail 2651 Not Applicable 
polypeptide OTTMUSP00000018931 VEGA | MGI Sequence Detail 557 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(4) UniProt(1)
Polymorphisms
PCR(1) : SNPs within 2kb(413 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001863 Glypican
InterPro IPR031180 Glypican-4
InterPro IPR019803 Glypican, conserved site
Protein Ontology PR:000008166 glypican-4
References
(Earliest) J:28429 Watanabe K, et al., K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney. J Cell Biol. 1995 Sep;130(5):1207-18
(Latest) J:219796 Ko JS, et al., PTPsigma functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1874-9
All references(63)
Other
accession IDs
MGD-MRK-29056, MGI:1925872, MGI:2147881, MGI:2147905, MGI:2152785

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory