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Gpc4 Gene Detail
Summary
  • Symbol
    Gpc4
  • Name
    glypican 4
  • Synonyms
    9530073D23Rik, K-glypican
  • Feature Type
    protein coding gene
  • IDs
    MGI:104902
    NCBI Gene: 14735
  • Gene Overview
    MyGene.info: GPC4
Location & Maps
more
  • Sequence Map
    ChrX:52053021-52165252 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      112232 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    GPC4, glypican 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GPC4, glypican 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    K-glypican
  • Links
    NCBI Gene ID: 2239
    neXtProt AC: NX_O75487

  • Chr Location
    Xq26.1; chrX:133301036-133415177 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 55582
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: GPC4
  • Protein SuperFamily
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human GPC4 associations

Human Disease Mouse Models
       Simpson-Golabi-Behmel Syndrome, Type 1; SGBS1   OMIM: 312870
Wilms Tumor 1; WT1   OMIM: 194070
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Gene trapped
    10
  • Targeted
    6
  • Incidental Mutations
    APF , CvDC
Male mice hemizygous for a null allele exhibit signs of anemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017330 VEGA Gene Model | MGI Sequence Detail 112232 C57BL/6J ±  kb
transcript OTTMUST00000042112 VEGA | MGI Sequence Detail 2651 Not Applicable  
polypeptide OTTMUSP00000018931 VEGA | MGI Sequence Detail 557 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    410 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
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  • All nucleic 25
    cDNA 21
    Primer pair 4

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-29056, MGI:1925872, MGI:2147881, MGI:2147905, MGI:2152785
References
more
  • Summaries
    All 60
    Developmental Gene Expression 12
    Gene Ontology 4
    Phenotypes 14
  • Earliest
    J:28429 Watanabe K, et al., K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney. J Cell Biol. 1995 Sep;130(5):1207-18
  • Latest
    J:219796 Ko JS, et al., PTPsigma functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1874-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory