About   Help   FAQ
Gpc4
Gene Detail
 Symbol
Name
ID
Gpc4
glypican 4
MGI:104902
Synonyms 9530073D23Rik, K-glypican
Feature Type protein coding gene
Genetic Map
Chromosome X
28.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
ChrX:52053021-52165252 bp, - strand
From VEGA annotation of GRCm38

  112232 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55582  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: glypican
Gene Tree: Gpc4

Human
homologs
Human Homolog GPC4, glypican 4
NCBI Gene ID 2239
neXtProt AC  NX_O75487
Human Synonyms  K-glypican
Human Chr (Location)  Xq26.1; chrX:133301036-133415177 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human GPC4
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(10) Targeted(5)
Incidental mutations (data from APF )
 
Hemizygous male mutant mice exhibit signs of anemia.
 
Interactions
Gpc4 interacts with 134 markers (Mir7-1, Mir17, Mir20a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Component anchored component of membrane, external side of plasma membrane, ...
Function heparan sulfate proteoglycan binding
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (471)    Tissues (108)    Images (73)
Theiler Stages: 11, 12, 13, 14, 15, 16, 17, 23
Assay TypeResults
Immunohistochemistry 6
RNA in situ 460
Western blot 4
RT-PCR 1
cDNA source data(21)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) cDNA(21) Primer pair(4)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000017330 (Evidence)
Ensembl Gene ModelENSMUSG00000031119 (Evidence)
Entrez Gene14735 (Evidence)
DFCITC1581967, TC1620737
DoTSDT.101185035, DT.111022063, DT.526694
NIA Mouse Gene IndexU039381, U260239
Consensus CDS ProjectCCDS30124.1
International Mouse Knockout Project StatusGpc4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017330 VEGA Gene Model | MGI Sequence Detail 112232 C57BL/6J ±  kb
transcript OTTMUST00000042112 VEGA | MGI Sequence Detail 2651 Not Applicable 
polypeptide OTTMUSP00000018931 VEGA | MGI Sequence Detail 557 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(1)
Polymorphisms PCR(1) : SNPs within 2kb(413 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001863 Glypican
InterPro IPR019803 Glypican, conserved site
Protein Ontology PR:000008166 glypican-4
References (Earliest) J:28429 Watanabe K, et al., K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney. J Cell Biol. 1995 Sep;130(5):1207-18
(Latest) J:201656 de Wit J, et al., Unbiased discovery of glypican as a receptor for LRRTM4 in regulating excitatory synapse development. Neuron. 2013 Aug 21;79(4):696-711
All references(60)
Other
accession IDs
MGD-MRK-29056, MGI:1925872, MGI:2147881, MGI:2147905, MGI:2152785

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory