Gpc4
Gene Detail

Symbol Name ID

Gpc4 glypican 4 MGI:104902

Synonyms

9530073D23Rik, K-glypican

Feature Type

protein coding gene

Genetic Map

Chromosome X

28.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

ChrX:52053021-52165252 bp, - strand From VEGA annotation of GRCm38   112232 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55582  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: glypican
Gene Tree: Gpc4

Human homologs

Human Homolog		GPC4, glypican 4
NCBI Gene ID		2239
neXtProt AC		NX_O75487
Human Synonyms		K-glypican
Human Chr (Location)		Xq26.1; chrX:132435064-132549205 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GPC4

Alleles and phenotypes

All alleles(15) : Targeted(5) Gene trapped(10)
 

Hemizygous male mutant mice exhibit signs of anemia.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Component	anchored to membrane, external side of plasma membrane, ...
Function	heparan sulfate proteoglycan binding

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (471)    Tissues (108)    Images (73)
Theiler Stages: 11, 12, 13, 14, 15, 16, 17, 23

Assay Type	Results
Immunohistochemistry	6
RNA in situ	460
Western blot	4
RT-PCR	1

cDNA source data(21)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(25) cDNA(21) Primer pair(4)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000017330 (Evidence)
Ensembl Gene Model	ENSMUSG00000031119 (Evidence)
Entrez Gene	14735 (Evidence)
DFCI	TC1581967, TC1620737
DoTS	DT.101185035, DT.111022063, DT.526694
NIA Mouse Gene Index	U039381, U260239
Consensus CDS Project	CCDS30124.1
International Mouse Knockout Project Status	Gpc4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017330	VEGA Gene Model | MGI Sequence Detail	112232	C57BL/6J
transcript	OTTMUST00000042112	VEGA | MGI Sequence Detail	2651	Not Applicable
polypeptide	OTTMUSP00000018931	VEGA | MGI Sequence Detail	557	Not Applicable

All sequences(35) RefSeq(2) UniProt(2)

Polymorphisms

PCR(1) : SNPs(385 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001863	Glypican
InterPro	IPR019803	Glypican, conserved site
Protein Ontology	PR:000008166	glypican-4

References

(Earliest) J:28429 Watanabe K, et al., K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney. J Cell Biol. 1995 Sep;130(5):1207-18
(Latest) J:186711 Allen NJ, et al., Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors. Nature. 2012 Jun 21;486(7403):410-4
All references(57)

Other accession IDs

MGD-MRK-29056, MGI:1925872, MGI:2147881, MGI:2147905, MGI:2152785