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Rest Gene Detail
Summary
  • Symbol
    Rest
  • Name
    RE1-silencing transcription factor
  • Synonyms
    2610008J04Rik, NRSF
  • Feature Type
    protein coding gene
  • IDs
    MGI:104897
    NCBI Gene: 19712
Location & Maps
more
  • Sequence Map
    Chr5:77265491-77286432 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      20942 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 41.61 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    REST, RE1 silencing transcription factor
  • Vertebrate Orthologs
    8
  • Human Ortholog
    REST, RE1 silencing transcription factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NRSF, WT6, XBR
  • Links
    NCBI Gene ID: 5978
    neXtProt AC: NX_Q13127

  • Chr Location
    4q12; chr4:56907876-56935845 (+)  GRCh38.p2
Human Diseases
more
  • Diseases
    1 with human REST associations

Human Disease Mouse Models
       Wilms Tumor 6; WT6   OMIM: 616806
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 8 alleles in 7 genetic backgrounds
    5 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    157
  • Chemically induced (other)
    2
  • Gene trapped
    140
  • Spontaneous
    1
  • Targeted
    14
  • Genomic Mutations
    3 involving Rest
  • Incidental Mutations
    Mutagenetix , APF
Targeted mutation of this gene results in embryonic lethality preceded by growth retardation and abnormal cellular organization in several tissues, including the hindbrain and somites. Mice with conditional deletions exhibit increased apoptosis in affected cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    64
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    145
  • Tissues
    104
  • cDNA Data
    17
  • Literature Summary
    30
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021414 VEGA Gene Model | MGI Sequence Detail 20942 C57BL/6J ±  kb
transcript OTTMUST00000050751 VEGA | MGI Sequence Detail 7004 Not Applicable  
polypeptide OTTMUSP00000023777 VEGA | MGI Sequence Detail 1082 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    85 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000013894 RE1-silencing transcription factor
  • InterPro Domains
    IPR027775 C2H2- zinc finger protein family
    IPR027757 RE1-silencing transcription factor
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
less
  • All nucleic 23
    cDNA 18
    Primer pair 5

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-29050, MGI:1919377
References
more
  • Summaries
    All 115
    Developmental Gene Expression 30
    Gene Ontology 14
    Phenotypes 36
  • Earliest
    J:23978 Schoenherr CJ, et al., The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes. Science. 1995 Mar 3;267(5202):1360-3
  • Latest
    J:229930 Nechiporuk T, et al., The REST remodeling complex protects genomic integrity during embryonic neurogenesis. Elife. 2016;5
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory