Rest
Gene Detail

Symbol

Name
ID

Rest
RE1-silencing transcription factor
MGI:104897

Synonyms

2610008J04Rik, NRSF

Feature Type

protein coding gene

Genetic Map

Chromosome 5
41.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr5:77265491-77286432 bp, + strand From VEGA annotation of GRCm38   20942 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:4099  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Rest

Human
homologs

Human Homolog		REST, RE1-silencing transcription factor
NCBI Gene ID		5978
neXtProt AC		NX_Q13127
Human Synonyms		NRSF, XBR
Human Chr (Location)		4q12; chr4:56907876-56935844 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(152) : Gene trapped(140) Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 

Targeted mutation of this gene results in embryonic lethality preceded by growth retardation and abnormal cellular organization in several tissues, including the hindbrain and somites. Mice with conditional deletions exhibit increased apoptosis in affected cells.

 

Interactions

Rest interacts with 376 markers (Mir7-1, Mir7-2, Mir7b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (69 annotations)

Process	cardiac muscle cell myoblast differentiation, cellular response to drug, ...
Component	chromatin, cytosol, ...
Function	chromatin binding, core promoter binding, ...

External Resources: FuncBase

Expression

Literature Summary: (25 records)

Data Summary: Results (128)    Tissues (95)    Images (16)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	106
RT-PCR	22

cDNA source data(17)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular
reagents

All nucleic(22) cDNA(18) Primer pair(4)
Microarray probesets(7)

Other database
links

VEGA Gene Model	OTTMUSG00000021414 (Evidence)
Ensembl Gene Model	ENSMUSG00000029249 (Evidence)
Entrez Gene	19712 (Evidence)
DFCI	TC1629649, TC1613389, TC1680681, TC1647156, TC1688514
DoTS	DT.94020992, DT.91569213, DT.492464, DT.101375132, DT.101142681, DT.97411880, DT.94223288
NIA Mouse Gene Index	U042648
Consensus CDS Project	CCDS19372.1
International Mouse Knockout Project Status	Rest

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021414	VEGA Gene Model | MGI Sequence Detail	20942	C57BL/6J
transcript	OTTMUST00000050751	VEGA | MGI Sequence Detail	7004	Not Applicable
polypeptide	OTTMUSP00000023777	VEGA | MGI Sequence Detail	1082	Not Applicable

All sequences(58) RefSeq(6) UniProt(3)

Polymorphisms

SNPs within 2kb(69 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000013894	RE1-silencing transcription factor

References

(Earliest) J:23978 Schoenherr CJ, et al., The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes. Science. 1995 Mar 3;267(5202):1360-3
(Latest) J:214998 Tint GS, et al., Desmosterol in brain is elevated because DHCR24 needs REST for Robust Expression but REST is poorly expressed. Dev Neurosci. 2014;36(2):132-42
All references(103)

Other
accession IDs

MGD-MRK-29050, MGI:1919377