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Rest
Gene Detail
Symbol

Name
ID
Rest
RE1-silencing transcription factor
MGI:104897
Synonyms
2610008J04Rik, NRSF
Feature Type
protein coding gene
Genetic Map
Chromosome 5
41.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:77265491-77286432 bp, + strand
From VEGA annotation of GRCm38

  20942 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4099  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: REST
Gene Tree: Rest

Human
homologs
REST, RE1-silencing transcription factor
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5978
neXtProt AC: NX_Q13127

Human Synonyms: NRSF, XBR

Human Chr (Location): 4q12; chr4:56907876-56935845 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(152) : Gene trapped(140) Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted mutation of this gene results in embryonic lethality preceded by growth retardation and abnormal cellular organization in several tissues, including the hindbrain and somites. Mice with conditional deletions exhibit increased apoptosis in affected cells.
 
Interactions
Rest interacts with 376 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (70 annotations)
Process cardiac muscle cell myoblast differentiation, cellular response to drug, ...
Component chromatin, cytosol, ...
Function chromatin binding, core promoter binding, ...
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (133)    Tissues (97)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 106
RT-PCR 27
cDNA source data(17)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA REST ; Xenbase rest ; ZFIN rest    NEW 
Molecular
reagents
All nucleic(23) cDNA(18) Primer pair(5)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000021414 (Evidence)
Ensembl Gene Model ENSMUSG00000029249 (Evidence)
Entrez Gene 19712 (Evidence)
DFCI TC1613389, TC1629649, TC1647156, TC1680681, TC1688514
DoTS DT.101142681, DT.101375132, DT.492464, DT.91569213, DT.94020992, DT.94223288, DT.97411880
NIA Mouse Gene Index U042648
Consensus CDS Project CCDS19372.1
International Mouse Phenotyping Consortium Status Rest
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021414 VEGA Gene Model | MGI Sequence Detail 20942 C57BL/6J ±  kb
transcript OTTMUST00000050752 VEGA | MGI Sequence Detail 6924 Not Applicable 
polypeptide OTTMUSP00000023778 VEGA | MGI Sequence Detail 1082 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(69 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000013894 RE1-silencing transcription factor
References
(Earliest) J:23978 Schoenherr CJ, et al., The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes. Science. 1995 Mar 3;267(5202):1360-3
(Latest) J:215180 Seki M, et al., A comparison of the rest complex binding patterns in embryonic stem cells and epiblast stem cells. PLoS One. 2014;9(4):e95374
All references(105)
Other
accession IDs
MGD-MRK-29050, MGI:1919377

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory