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Rest
Gene Detail
 Symbol
Name
ID
Rest
RE1-silencing transcription factor
MGI:104897
Synonyms 2610008J04Rik, NRSF
Feature Type protein coding gene
Genetic Map
Chromosome 5
41.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:77265491-77286432 bp, + strand
From VEGA annotation of GRCm38

  20942 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4099  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Rest

Human
homologs
Human Homolog REST, RE1-silencing transcription factor
NCBI Gene ID 5978
neXtProt AC  NX_Q13127
Human Synonyms  NRSF, XBR
Human Chr (Location)  4q12; chr4:56907876-56935844 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(152) : Gene trapped(140) Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted mutation of this gene results in embryonic lethality preceded by growth retardation and abnormal cellular organization in several tissues, including the hindbrain and somites. Mice with conditional deletions exhibit increased apoptosis in affected cells.
 
Interactions
Rest interacts with 376 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (67 annotations)
Process cardiac muscle cell myoblast differentiation, cellular response to drug, ...
Component chromatin, cytosol, ...
Function chromatin binding, core promoter binding, ...
External Resources: FuncBase
Expression
Literature Summary: (24 records)
Data Summary: Results (128)    Tissues (95)    Images (16)
Theiler Stages: 2, 3, 4, 5, 17, 18, 19, 21, 22, 23, 24, 27, 28
Assay TypeResults
RNA in situ 106
RT-PCR 22
cDNA source data(17)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) cDNA(18) Primer pair(4)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000021414 (Evidence)
Ensembl Gene ModelENSMUSG00000029249 (Evidence)
Entrez Gene19712 (Evidence)
DFCITC1613389, TC1629649, TC1647156, TC1680681, TC1688514
DoTSDT.101142681, DT.101375132, DT.492464, DT.91569213, DT.94020992, DT.94223288, DT.97411880
NIA Mouse Gene IndexU042648
Consensus CDS ProjectCCDS19372.1
International Mouse Knockout Project StatusRest
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021414 VEGA Gene Model | MGI Sequence Detail 20942 C57BL/6J ±  kb
transcript OTTMUST00000050751 VEGA | MGI Sequence Detail 7004 Not Applicable 
polypeptide OTTMUSP00000023777 VEGA | MGI Sequence Detail 1082 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(6) UniProt(2)
Polymorphisms SNPs within 2kb(69 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000013894 RE1-silencing transcription factor
References (Earliest) J:23978 Schoenherr CJ, et al., The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes. Science. 1995 Mar 3;267(5202):1360-3
(Latest) J:208883 Lu T, et al., REST and stress resistance in ageing and Alzheimer's disease. Nature. 2014 Mar 27;507(7493):448-54
All references(102)
Other
accession IDs
MGD-MRK-29050, MGI:1919377

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory