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Rest Gene Detail
Summary
  • Symbol
    Rest
  • Name
    RE1-silencing transcription factor
  • Synonyms
    2610008J04Rik, NRSF
  • Feature Type
    protein coding gene
  • IDs
    MGI:104897
    NCBI Gene: 19712
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr5:77265491-77286432 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      20942 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 41.61 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    REST, RE1 silencing transcription factor
  • Vertebrate Orthologs
    8
  • Human Ortholog
    REST, RE1 silencing transcription factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GINGF5, HGF5, NRSF, WT6, XBR
  • Links
    NCBI Gene ID: 5978
    neXtProt AC: NX_Q13127
    UniProt: Q13127

  • Chr Location
    4q12; chr4:56907876-56935847 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human REST associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 8 alleles in 7 genetic backgrounds
    21 phenotypes from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted mutation of this gene results in embryonic lethality preceded by growth retardation and abnormal cellular organization in several tissues, including the hindbrain and somites. Mice with conditional deletions exhibit increased apoptosis in affected cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    62
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    148
  • Tissues
    105
  • cDNA Data
    17
  • Literature Summary
    35
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000021414 VEGA Gene Model | MGI Sequence Detail 20942 C57BL/6J ±  kb
    transcript OTTMUST00000050751 VEGA | MGI Sequence Detail 7004 Not Applicable  
    polypeptide OTTMUSP00000023777 VEGA | MGI Sequence Detail 1082 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      85 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 18
      Primer pair 6

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-29050, MGI:1919377
    References
    more
    • Summaries
      All 144
      Developmental Gene Expression 35
      Diseases 1
      Gene Ontology 16
      Phenotypes 44
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:255076 Zhang D, et al., REST regulates the cell cycle for cardiac development and regeneration. Nat Commun. 2017 Dec 7;8(1):1979
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/12/2018
    MGI 6.12     		The Jackson Laboratory