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Tpt1 Gene Detail
Summary
  • Symbol
    Tpt1
  • Name
    tumor protein, translationally-controlled 1
  • Synonyms
    fortilin, TCTP, Trt
  • Feature Type
    protein coding gene
  • IDs
    MGI:104890
    NCBI Gene: 22070
Location & Maps
more
  • Sequence Map
    Chr14:75845093-75848525 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3433 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 40.29 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TPT1, tumor protein, translationally-controlled 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TPT1, tumor protein, translationally-controlled 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HRF, p02, p23, TCTP
  • Links
    NCBI Gene ID: 7178
    neXtProt AC: NX_P13693

  • Chr Location
    13q14; chr13:45333471-45341284 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 4 alleles in 6 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Gene trapped
    7
  • Targeted
    6
  • Genomic Mutations
    1 involving Tpt1
  • Incidental Mutations
Mice homozygous for a knock-out allele die prior to embryo turning due to defects in embryogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018220 VEGA Gene Model | MGI Sequence Detail 3433 C57BL/6J ±  kb
transcript OTTMUST00000044014 VEGA | MGI Sequence Detail 1169 Not Applicable  
polypeptide OTTMUSP00000019766 VEGA | MGI Sequence Detail 172 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    6 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000016596 translationally-controlled tumor protein
  • InterPro Domains
    IPR011057 Mss4-like
    IPR011323 Mss4/translationally controlled tumour-associated TCTP
    IPR018105 Translationally controlled tumour protein
    IPR018103 Translationally controlled tumour protein, conserved site
Molecular
Reagents
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  • All nucleic 998
    cDNA 996
    Primer pair 1
    Other 1

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-29043
References
more
  • Summaries
    All 53
    Developmental Gene Expression 7
    Gene Ontology 6
    Phenotypes 16
  • Earliest
    J:30851 Chitpatima ST, et al., Nucleotide sequence of a major messenger RNA for a 21 kilodalton polypeptide that is under translational control in mouse tumor cells. Nucleic Acids Res. 1988 Mar 25;16(5):2350
  • Latest
    J:216451 Choi SW, et al., Osteoclastogenic activity of translationally-controlled tumor protein (TCTP) with reciprocal repression of p21. FEBS Lett. 2014 Nov 3;588(21):4026-31

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory