About   Help   FAQ
Fdps Gene Detail
Summary
  • Symbol
    Fdps
  • Name
    farnesyl diphosphate synthetase
  • Synonyms
    6030492I17Rik, Fdpsl1, mKIAA1293
  • Feature Type
    protein coding gene
  • IDs
    MGI:104888
    NCBI Gene: 110196
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:89000895-89009266 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 39.01 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    258 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104888
 protein coding gene Chr3:89000895-89009274 (-)
129S1/SvImJ ENSMUSG00200037535
 protein coding gene Chr3:85855863-85864234 (-)
A/J ENSMUSG00195049849
 protein coding gene Chr3:85871197-85879566 (-)
AKR/J ENSMUSG00220050337
 protein coding gene Chr3:85825749-85834117 (-)
BALB/cJ ENSMUSG00180041719
 protein coding gene Chr3:85952662-85961033 (-)
C3H/HeJ ENSMUSG00175037924
 protein coding gene Chr3:85803837-85812205 (-)
C57BL/6NJ ENSMUSG00215049172
 protein coding gene Chr3:86243604-86251975 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025186
 protein coding gene Chr3:81819699-81828443 (-)
CAST/EiJ ENSTCUG00005045534
 protein coding gene Chr3:85319531-85327905 (-)
CBA/J ENSMUSG00210038584
 protein coding gene Chr3:85941505-85949873 (-)
DBA/2J ENSMUSG00185050533
 protein coding gene Chr3:86041192-86049563 (-)
FVB/NJ ENSMUSG00205047092
 protein coding gene Chr3:84865440-84873809 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230027453
 protein coding gene Chr3:88077196-88085567 (-)
NOD/ShiLtJ ENSMUSG00190044687
 protein coding gene Chr3:86326087-86334457 (-)
NZO/HlLtJ ENSMUSG00225006659
 protein coding gene Chr3:90832809-90841177 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010048045
 protein coding gene Chr3:86550814-86559189 (-)
WSB/EiJ ENSIUOG00005047493
 protein coding gene Chr3:86347146-86355517 (-)



Homology
more
  • Human Ortholog
    FDPS, farnesyl diphosphate synthase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FDPS, farnesyl diphosphate synthase
  • Synonyms
    FPPS, FPS, POROK9
  • Links
    NCBI Gene ID: 2224
    UniProt: P14324

  • Chr Location
    1q22; chr1:155304786-155320666 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human FDPS associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with cardiac-specific conditional deletion exhibit cardiac remodeling and dysfunction and death by 4 months of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1001
  • Tissues
    140
  • cDNA Data
    12
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059743 Ensembl Gene Model | MGI Sequence Detail 8372 C57BL/6J ±  kb
    transcript ENSMUST00000081848 Ensembl | MGI Sequence Detail 1237 Not Applicable  
    polypeptide ENSMUSP00000080531 Ensembl | MGI Sequence Detail 353 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 14
      Primer pair 4
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-29041, MGD-MRK-9744, MGI:2139654
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 14
      Phenotypes 11
    • Earliest
      J:371708 Bruenger E, et al., Determination of isopentenyl diphosphate and farnesyl diphosphate in tissue samples with a comment on secondary regulation of polyisoprenoid biosynthesis. Anal Biochem. 1988 Sep;173(2):321-7
    • Latest
      J:390602 Ji Z, et al., A metabolic alarmin from keratinocytes potentiates systemic humoral immunity. Nature. 2026 Apr;652(8108):209-219
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory