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Psmb6 Gene Detail
Summary
  • Symbol
    Psmb6
  • Name
    proteasome (prosome, macropain) subunit, beta type 6
  • Synonyms
    Lmp19, Mpnd, subunit 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:104880
    NCBI Gene: 19175
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:70416193-70418684 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 42.99 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    85 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104880
 protein coding gene Chr11:70416116-70418684 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018601
 protein coding gene Chr11:71061490-71063980 (+)
A/J MGP_AJ_G0018569
 protein coding gene Chr11:68366126-68368616 (+)
AKR/J MGP_AKRJ_G0018538
 protein coding gene Chr11:70422517-70425007 (+)
BALB/cJ MGP_BALBcJ_G0018541
 protein coding gene Chr11:68686731-68689221 (+)
C3H/HeJ MGP_C3HHeJ_G0018354
 protein coding gene Chr11:70449256-70451746 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018992
 protein coding gene Chr11:73214542-73217066 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016637
 protein coding gene Chr11:65287718-65290186 (+)
CAST/EiJ MGP_CASTEiJ_G0017909
 protein coding gene Chr11:70704496-70706992 (+)
CBA/J MGP_CBAJ_G0018326
 protein coding gene Chr11:76500917-76503407 (+)
DBA/2J MGP_DBA2J_G0018436
 protein coding gene Chr11:67949483-67951969 (+)
FVB/NJ MGP_FVBNJ_G0018426
 protein coding gene Chr11:67594874-67597364 (+)
LP/J MGP_LPJ_G0018506
 protein coding gene Chr11:71637400-71639890 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018449
 protein coding gene Chr11:77071680-77074170 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019034
 protein coding gene Chr11:70680868-70683358 (+)
PWK/PhJ MGP_PWKPhJ_G0017683
 protein coding gene Chr11:68589892-68592377 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017473
 protein coding gene Chr11:70494367-70496865 (+)
WSB/EiJ MGP_WSBEiJ_G0017963
 protein coding gene Chr11:70343717-70346207 (+)



Homology
more
  • Human Ortholog
    PSMB6, proteasome 20S subunit beta 6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PSMB6, proteasome 20S subunit beta 6
  • Synonyms
    DELTA, LMPY
  • Links
    NCBI Gene ID: 5694
    UniProt: P28072

  • Chr Location
    17p13.2; chr17:4796144-4798502 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    5
  • cDNA Data
    229
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000018286 Ensembl Gene Model | MGI Sequence Detail 2492 C57BL/6J ±  kb
transcript ENSMUST00000018430 Ensembl | MGI Sequence Detail 798 Not Applicable  
polypeptide ENSMUSP00000018430 Ensembl | MGI Sequence Detail 238 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 232
    Genomic 3
    cDNA 229

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-18666, MGD-MRK-24102, MGD-MRK-29033
References
more
  • Summaries
    All 51
    Developmental Gene Expression 5
    Gene Ontology 10
    Phenotypes 16
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:354587 Nedomova M, et al., DDI2 protease controls embryonic development and inflammation via TCF11/NRF1. iScience. 2024 Oct 18;27(10):110893
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory