Ppp1cc
Gene Detail

Symbol Name ID

Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform MGI:104872

Synonyms

PP1, PP1C gamma, PP1C gamma 1, PP1C gamma 2

Feature Type

protein coding gene

Genetic Map

Chromosome 5

62.20 cM, cytoband F-G1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr5:122158278-122175273 bp, + strand From VEGA annotation of GRCm38   16996 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:100608  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: serine/threonine-protein phosphatase, conventional type
Gene Tree: Ppp1cc

Human homologs

Human Homolog		PPP1CC, protein phosphatase 1, catalytic subunit, gamma isozyme
NCBI Gene ID		5501
neXtProt AC		NX_P36873
Human Synonyms		PP1C, PP-1G, PPP1G
Human Chr (Location)		12q24.1-q24.2; chr12:111157613-111180783 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(46) : Targeted(5) Gene trapped(41)
 

Homozygotes for a targeted null mutation exhibit male infertility due to severely impaired spermiogenesis.

 

Gene Ontology (GO) classifications

All GO classifications: (34 annotations)

Process	carbohydrate metabolic process, cell cycle, ...
Component	chromosome, chromosome, centromeric region, ...
Function	hydrolase activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (30)    Tissues (30)    Images (9)
Theiler Stages: 19, 21, 23, 28

Assay Type	Results
RNA in situ	29
Western blot	1

cDNA source data(337)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(339) Genomic(2) cDNA(337)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000016349 (Evidence)
Ensembl Gene Model	ENSMUSG00000004455 (Evidence)
Entrez Gene	19047 (Evidence)
UniGene	280784
EC	3.1.3.16
Consensus CDS Project	CCDS19643.1
International Mouse Knockout Project Status	Ppp1cc

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016349	VEGA Gene Model | MGI Sequence Detail	16996	C57BL/6J
transcript	OTTMUST00000039309	VEGA | MGI Sequence Detail	1442	Not Applicable
polypeptide	OTTMUSP00000017568	VEGA | MGI Sequence Detail	337	Not Applicable

All sequences(61) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(19 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004843	Metallophosphoesterase domain
InterPro	IPR006186	Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Protein Ontology	PR:000013104	serine/threonine-protein phosphatase PP1-gamma catalytic subunit

References

(Earliest) J:30044 Ohkura H, et al., The fission yeast dis2+ gene required for chromosome disjoining encodes one of two putative type 1 protein phosphatases. Cell. 1989 Jun 16;57(6):997-1007
(Latest) J:193748 MacLeod G, et al., Tandem affinity purification in transgenic mouse embryonic stem cells identifies DDOST as a novel PPP1CC2 interacting protein. Biochemistry. 2012 Dec 4;51(48):9678-88
All references(70)

Other accession IDs

MGD-MRK-28171