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Ppp1cc Gene Detail
Summary
  • Symbol
    Ppp1cc
  • Name
    protein phosphatase 1, catalytic subunit, gamma isoform
  • Synonyms
    PP1, PP1C gamma, PP1C gamma 1, PP1C gamma 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:104872
    NCBI Gene: 19047
  • Gene Overview
    MyGene.info: PPP1CC
Location & Maps
more
  • Sequence Map
    Chr5:122158278-122175273 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16996 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 62.20 cM, cytoband F-G1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PPP1CC, protein phosphatase 1 catalytic subunit gamma
  • Vertebrate Orthologs
    2
  • Human Ortholog
    PPP1CC, protein phosphatase 1 catalytic subunit gamma
    Orthology source: HGNC
  • Synonyms
    PP1C, PP-1G, PPP1G
  • Links
    NCBI Gene ID: 5501
    neXtProt AC: NX_P36873

  • Chr Location
    12q24.1-q24.2; chr12:110708970-110742978 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 2 alleles in 3 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    45
  • Chemically induced (other)
    1
  • Gene trapped
    37
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    2 involving Ppp1cc
Homozygotes for a targeted null mutation exhibit male infertility due to severely impaired spermiogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016349 VEGA Gene Model | MGI Sequence Detail 16996 C57BL/6J ±  kb
transcript OTTMUST00000039309 VEGA | MGI Sequence Detail 1442 Not Applicable  
polypeptide OTTMUSP00000017568 VEGA | MGI Sequence Detail 337 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    29 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000013104 serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Molecular
Reagents
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  • All nucleic 22
    Genomic 2
    cDNA 20

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-28171
References
more
  • Summaries
    All 71
    Developmental Gene Expression 6
    Gene Ontology 12
    Phenotypes 30
  • Earliest
    J:30044 Ohkura H, et al., The fission yeast dis2+ gene required for chromosome disjoining encodes one of two putative type 1 protein phosphatases. Cell. 1989 Jun 16;57(6):997-1007
  • Latest
    J:229419 Liu R, et al., Cardiac-specific deletion of protein phosphatase 1beta promotes increased myofilament protein phosphorylation and contractile alterations. J Mol Cell Cardiol. 2015 Oct;87:204-13

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory