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Ppp1cc Gene Detail
Summary
  • Symbol
    Ppp1cc
  • Name
    protein phosphatase 1 catalytic subunit gamma
  • Synonyms
    PP1, PP1C gamma, PP1C gamma 1, PP1C gamma 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:104872
    NCBI Gene: 19047
  • Gene Overview
    MyGene.info: PPP1CC
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr5:122158278-122175273 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 62.20 cM, cytoband F-G1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    29 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104872
protein coding gene Chr5:122158254-122175273 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030043
protein coding gene Chr5:125775266-125794436 (+)
A/J MGP_AJ_G0030008
protein coding gene Chr5:120575174-120594320 (+)
AKR/J MGP_AKRJ_G0029944
protein coding gene Chr5:124442198-124458947 (+)
BALB/cJ MGP_BALBcJ_G0030019
protein coding gene Chr5:121923210-121940841 (+)
C3H/HeJ MGP_C3HHeJ_G0029736
protein coding gene Chr5:125059708-125080002 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030472
protein coding gene Chr5:130609301-130628453 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027698
protein coding gene Chr5:115190641-115204862 (+)
CAST/EiJ MGP_CASTEiJ_G0029145
protein coding gene Chr5:124163288-124181972 (+)
CBA/J MGP_CBAJ_G0029706
protein coding gene Chr5:135728011-135744319 (+)
DBA/2J MGP_DBA2J_G0029856
protein coding gene Chr5:120629413-120647145 (+)
FVB/NJ MGP_FVBNJ_G0029812
protein coding gene Chr5:119607451-119626199 (+)
LP/J MGP_LPJ_G0029945
protein coding gene Chr5:126309993-126332625 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029843
protein coding gene Chr5:139501038-139521372 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030513
protein coding gene Chr5:124022577-124041576 (+)
PWK/PhJ MGP_PWKPhJ_G0028859
protein coding gene Chr5:119397502-119415896 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028696
protein coding gene Chr5:121747243-121768229 (+)
WSB/EiJ MGP_WSBEiJ_G0029220
protein coding gene Chr5:124707731-124725266 (+)



Homology
more
  • Human Ortholog
    PPP1CC, protein phosphatase 1 catalytic subunit gamma
  • Vertebrate Orthologs
    2
  • Human Ortholog
    PPP1CC, protein phosphatase 1 catalytic subunit gamma
    Orthology source: HGNC
  • Synonyms
    PP1C, PP-1G, PPP1G
  • Links
    NCBI Gene ID: 5501
    neXtProt AC: NX_P36873
    UniProt: P36873

  • Chr Location
    12q24.11; chr12:110708369-110742978 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 3 alleles in 4 genetic backgrounds
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit male infertility due to severely impaired spermiogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000004455 Ensembl Gene Model | MGI Sequence Detail 16996 C57BL/6J ±  kb
    transcript ENSMUST00000086294 Ensembl | MGI Sequence Detail 1442 Not Applicable  
    polypeptide ENSMUSP00000083474 Ensembl | MGI Sequence Detail 337 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 2
      cDNA 21

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-28171
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 6
      Gene Ontology 12
      Phenotypes 33
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:251541 Silva JV, et al., Construction and analysis of a human testis/sperm-enriched interaction network: Unraveling the PPP1CC2 interactome. Biochim Biophys Acta. 2017 Feb;1861(2):375-385

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory