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Ppp1cb
Gene Detail
 Symbol
Name
ID
Ppp1cb
protein phosphatase 1, catalytic subunit, beta isoform
MGI:104871
Feature Type protein coding gene
Genetic Map
Chromosome 5
17.33 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:32458974-32517433 bp, + strand
From VEGA annotation of GRCm38

  58460 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37659  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: serine/threonine-protein phosphatase, conventional type
Gene Tree: Ppp1cb

Human
homologs
Human Homolog PPP1CB, protein phosphatase 1, catalytic subunit, beta isozyme
NCBI Gene ID 5500
neXtProt AC  NX_P62140
Human Synonyms  HEL-S-80p, PP1B, PP-1B, PP1beta, PPP1CD
Human Chr (Location)  2p23; chr2:28751748-28802940 (+)  GRCh38
Alleles
and
phenotypes
All alleles(22) : Gene trapped(21) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in lethality before weaning.
 
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process carbohydrate metabolic process, cell cycle, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function hydrolase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (15)    Tissues (6)    Images (1)
Theiler Stages: 17, 21, 28
Assay TypeResults
RNA in situ 1
Western blot 5
RT-PCR 9
cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(22) cDNA(19) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000024328 (Evidence)
Ensembl Gene ModelENSMUSG00000014956 (Evidence)
Entrez Gene19046 (Evidence)
DFCITC1573823, TC1581286, TC1621021, TC1760500
DoTSDT.101220720, DT.101739134, DT.101739135, DT.97403589
NIA Mouse Gene IndexU005461
EC3.1.3.16, 3.1.3.53
Consensus CDS ProjectCCDS19193.1
International Mouse Knockout Project StatusPpp1cb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024328 VEGA Gene Model | MGI Sequence Detail 58460 C57BL/6J ±  kb
transcript OTTMUST00000059605 VEGA | MGI Sequence Detail 5831 Not Applicable 
polypeptide OTTMUSP00000029005 VEGA | MGI Sequence Detail 327 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(213 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004843 Metallophosphoesterase domain
InterPro IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Protein Ontology PR:000013103 serine/threonine-protein phosphatase PP1-beta catalytic subunit
References (Earliest) J:30044 Ohkura H, et al., The fission yeast dis2+ gene required for chromosome disjoining encodes one of two putative type 1 protein phosphatases. Cell. 1989 Jun 16;57(6):997-1007
(Latest) J:191730 Garcia-Haro L, et al., Glucose-dependent regulation of AMP-activated protein kinase in MIN6 beta cells is not affected by the protein kinase A pathway. FEBS Lett. 2012 Nov 30;586(23):4241-7
All references(49)
Other
accession IDs
MGD-MRK-28170

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory