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Ppp1cb Gene Detail
Summary
  • Symbol
    Ppp1cb
  • Name
    protein phosphatase 1, catalytic subunit, beta isoform
  • Feature Type
    protein coding gene
  • IDs
    MGI:104871
    NCBI Gene: 19046
  • Gene Overview
    MyGene.info: PPP1CB
Location & Maps
more
  • Sequence Map
    Chr5:32458843-32517433 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      58591 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PPP1CB, protein phosphatase 1 catalytic subunit beta
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PPP1CB, protein phosphatase 1 catalytic subunit beta
    Orthology source: HomoloGene
  • Synonyms
    HEL-S-80p, PP1B, PP-1B, PP1beta, PPP1CD
  • Links
    NCBI Gene ID: 5500
    neXtProt AC: NX_P62140

  • Chr Location
    2p23; chr2:28751748-28802940 (+)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    24
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Gene trapped
    16
  • Radiation induced
    3
  • Spontaneous
    1
  • Targeted
    1
  • Genomic Mutations
    7 involving Ppp1cb
  • Incidental Mutations
Homozygous mutation of this gene results in lethality before weaning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024328 VEGA Gene Model | MGI Sequence Detail 58591 C57BL/6J ±  kb
transcript OTTMUST00000059606 VEGA | MGI Sequence Detail 2347 Not Applicable  
polypeptide OTTMUSP00000029006 VEGA | MGI Sequence Detail 327 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    211 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000013103 serine/threonine-protein phosphatase PP1-beta catalytic subunit
  • EC
  • InterPro Domains
    IPR004843 Calcineurin-like phosphoesterase domain, apaH type
    IPR029052 Metallo-dependent phosphatase-like
    IPR031675 Serine-threonine protein phosphatase, N-terminal
    IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Molecular
Reagents
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  • All nucleic 22
    cDNA 19
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-28170
References
more
  • Summaries
    All 44
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 8
    Phenotypes 30
  • Earliest
    J:30044 Ohkura H, et al., The fission yeast dis2+ gene required for chromosome disjoining encodes one of two putative type 1 protein phosphatases. Cell. 1989 Jun 16;57(6):997-1007
  • Latest
    J:191730 Garcia-Haro L, et al., Glucose-dependent regulation of AMP-activated protein kinase in MIN6 beta cells is not affected by the protein kinase A pathway. FEBS Lett. 2012 Nov 30;586(23):4241-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory