Ppp1cb
Gene Detail

Symbol Name ID

Ppp1cb protein phosphatase 1, catalytic subunit, beta isoform MGI:104871

Feature Type

protein coding gene

Genetic Map

Chromosome 5

17.33 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr5:32458974-32517433 bp, + strand From VEGA annotation of GRCm38   58460 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic; rabbit, European    (Mammalian Orthology)
Comparative Map (Mouse/Human Ppp1cb ± 2 cM)

Protein SuperFamily: serine/threonine-protein phosphatase, conventional type
Gene Tree: Ppp1cb

Human ortholog

PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme NCBI Gene ID 5500
Human Synonyms: PP1B, PP-1B, PP1beta, PPP1CD
Human Chr2:28974614-29025806 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(22) : Targeted(1) Gene trapped(21)
 

Homozygous mutation of this gene results in lethality before weaning.

 

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	carbohydrate metabolic process, cell cycle, ...
Component	cytoplasm, glycogen granule, ...
Function	hydrolase activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (15)    Tissues (6)    Images (1)
Theiler Stages: 17, 21, 28

Assay Type	Results
RNA in situ	1
Western blot	5
RT-PCR	9

cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(22) cDNA(19) Primer pair(3)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000024328 (Evidence)
Ensembl Gene Model	ENSMUSG00000014956 (Evidence)
Entrez Gene	19046 (Evidence)
DFCI	TC1573823, TC1581286, TC1621021, TC1760500
DoTS	DT.101220720, DT.101739134, DT.101739135, DT.97403589
NIA Mouse Gene Index	U005461
EC	3.1.3.16, 3.1.3.53
Consensus CDS Project	CCDS19193.1
International Mouse Knockout Project Status	Ppp1cb

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024328	VEGA Gene Model | MGI Sequence Detail	58460	C57BL/6J
transcript	OTTMUST00000059605	VEGA | MGI Sequence Detail	5831	Not Applicable
polypeptide	OTTMUSP00000029005	VEGA | MGI Sequence Detail	327	Not Applicable

All sequences(54) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(82 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004843	Metallophosphoesterase domain
InterPro	IPR006186	Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Protein Ontology	PR:000013103	serine/threonine-protein phosphatase PP1-beta catalytic subunit

References

(Earliest) J:30044 Ohkura H, et al., The fission yeast dis2+ gene required for chromosome disjoining encodes one of two putative type 1 protein phosphatases. Cell. 1989 Jun 16;57(6):997-1007
(Latest) J:191730 Garcia-Haro L, et al., Glucose-dependent regulation of AMP-activated protein kinase in MIN6 beta cells is not affected by the protein kinase A pathway. FEBS Lett. 2012 Nov 30;586(23):4241-7
All references(48)

Other accession IDs

MGD-MRK-28170