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Ppp1cb Gene Detail
Summary
  • Symbol
    Ppp1cb
  • Name
    protein phosphatase 1 catalytic subunit beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:104871
    NCBI Gene: 19046
  • Gene Overview
    MyGene.info: PPP1CB
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:32458848-32493712 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 17.33 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    102 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104871
protein coding gene Chr5:32458843-32517433 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029435
protein coding gene Chr5:30553271-30615437 (+)
A/J MGP_AJ_G0029401
protein coding gene Chr5:29539807-29596840 (+)
AKR/J MGP_AKRJ_G0029351
protein coding gene Chr5:30709310-30771598 (+)
BALB/cJ MGP_BALBcJ_G0029412
protein coding gene Chr5:30067602-30128903 (+)
C3H/HeJ MGP_C3HHeJ_G0029133
protein coding gene Chr5:30726047-30786218 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029865
protein coding gene Chr5:32342653-32415419 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027103
protein coding gene Chr5:27198656-27256609 (+)
CAST/EiJ MGP_CASTEiJ_G0028543
protein coding gene Chr5:29817560-29878184 (+)
CBA/J MGP_CBAJ_G0029101
protein coding gene Chr5:33046937-33110534 (+)
DBA/2J MGP_DBA2J_G0029250
protein coding gene Chr5:29706825-29765491 (+)
FVB/NJ MGP_FVBNJ_G0029208
protein coding gene Chr5:29124732-29181964 (+)
LP/J MGP_LPJ_G0029335
protein coding gene Chr5:30984974-31045034 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029237
protein coding gene Chr5:33839317-33907015 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029899
protein coding gene Chr5:30210430-30271498 (+)
PWK/PhJ MGP_PWKPhJ_G0028268
protein coding gene Chr5:28871926-28932071 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028099
protein coding gene Chr5:29691362-29750383 (+)
WSB/EiJ MGP_WSBEiJ_G0028624
protein coding gene Chr5:30302601-30362834 (+)



Homology
more
  • Human Ortholog
    PPP1CB, protein phosphatase 1 catalytic subunit beta
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PPP1CB, protein phosphatase 1 catalytic subunit beta
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HEL-S-80p, NSLH2, PP1B, PP-1B, PP1beta, PPP1CD
  • Links
    NCBI Gene ID: 5500
    neXtProt AC: NX_P62140
    UniProt: P62140

  • Chr Location
    2p23.2; chr2:28751748-28802940 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Gene trapped
    16
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    1
  • Genomic Mutations
    6 involving Ppp1cb
  • Incidental Mutations
  • Find Mice (IMSR)
Homozygous mutation of this gene results in lethality before weaning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19046 NCBI Gene Model | MGI Sequence Detail 34865 C57BL/6J ±  kb
transcript NM_172707 RefSeq | MGI Sequence Detail 4024 C57BL/6  
polypeptide P62141 UniProt | EBI | MGI Sequence Detail 327 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000013103 serine/threonine-protein phosphatase PP1-beta catalytic subunit
  • EC
  • InterPro Domains
    IPR004843 Calcineurin-like phosphoesterase domain, ApaH type
    IPR029052 Metallo-dependent phosphatase-like
    IPR031675 Serine-threonine protein phosphatase, N-terminal
    IPR037979 Serine/threonine-protein phosphatase PP1 catalytic subunit alpha/beta
    IPR037981 Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
    IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Molecular
Reagents
less
  • All nucleic 23
    cDNA 20
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-28170
References
more
  • Summaries
    All 69
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 10
    Phenotypes 30
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:240750 Bose SK, et al., Hepatic Glucocorticoid Receptor Plays a Greater Role Than Adipose GR in Metabolic Syndrome Despite Renal Compensation. Endocrinology. 2016 Dec;157(12):4943-4960

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/11/2018
MGI 6.13
The Jackson Laboratory