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Fxr1 Gene Detail
Summary
  • Symbol
    Fxr1
  • Name
    fragile X mental retardation gene 1, autosomal homolog
  • Synonyms
    1110050J02Rik, 9530073J07Rik, Fxr1h, Fxr1p
  • Feature Type
    protein coding gene
  • IDs
    MGI:104860
    NCBI Gene: 14359
  • Gene Overview
    MyGene.info: FXR1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:34019943-34070322 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      50380 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 16.41 cM, cytoband B
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    FXR1, FMR1 autosomal homolog 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FXR1, FMR1 autosomal homolog 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FXR1P
  • Links
    NCBI Gene ID: 8087
    neXtProt AC: NX_P51114
    UniProt: P51114

  • Chr Location
    3q26.33; chr3:180912446-180982753 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3573
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FXR1
  • Gene Tree
Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 3 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display neonatal lethality with impaired muscle development. Mice homozygous for a hypomorphic allele display a reduced life span with impaired muscle development, growth retardation, and reduced grip strength.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000052173 VEGA Gene Model | MGI Sequence Detail 50380 C57BL/6J ±  kb
    transcript OTTMUST00000131174 VEGA | MGI Sequence Detail 2459 Not Applicable  
    polypeptide OTTMUSP00000070202 VEGA | MGI Sequence Detail 677 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      368 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 16
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-28157, MGI:1924160, MGI:1925815, MGI:2139822
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 12
      Phenotypes 15
    • Earliest
      J:30134 Coy JF, et al., Highly conserved 3' UTR and expression pattern of FXR1 points to a divergent gene regulation of FXR1 and FMR1. Hum Mol Genet. 1995 Dec;4(12):2209-18
    • Latest
      J:255973 Qie S, et al., Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma. Nat Commun. 2017 Nov 16;8(1):1534

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory