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Ptcra Gene Detail
Summary
  • Symbol
    Ptcra
  • Name
    pre T cell antigen receptor alpha
  • Synonyms
    pT[a], pTalpha, pT-alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:104857
    NCBI Gene: 19208
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:46755663-46763712 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 22.90 cM, cytoband D-E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    87 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104857
protein coding gene Chr17:46755663-46763712 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023832
protein coding gene Chr17:47850406-47859840 (-)
A/J MGP_AJ_G0023790
protein coding gene Chr17:46689214-46697879 (-)
AKR/J MGP_AKRJ_G0023761
protein coding gene Chr17:47036099-47044146 (-)
BALB/cJ MGP_BALBcJ_G0023794
protein coding gene Chr17:46590182-46598915 (-)
C3H/HeJ MGP_C3HHeJ_G0023557
protein coding gene Chr17:47786486-47794535 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024237
protein coding gene Chr17:49896611-49904660 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021687
protein coding gene Chr17:43469105-43477285 (-)
CAST/EiJ MGP_CASTEiJ_G0023039
protein coding gene Chr17:47874905-47884699 (-)
CBA/J MGP_CBAJ_G0023534
protein coding gene Chr17:51690439-51698418 (-)
DBA/2J MGP_DBA2J_G0023660
protein coding gene Chr17:45458231-45466280 (-)
FVB/NJ MGP_FVBNJ_G0023627
protein coding gene Chr17:45089208-45097235 (-)
LP/J MGP_LPJ_G0023741
protein coding gene Chr17:48521855-48531372 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023656
protein coding gene Chr17:51229107-51237178 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024282
protein coding gene Chr17:47391220-47407578 (-)
PWK/PhJ MGP_PWKPhJ_G0022783
protein coding gene Chr17:44799842-44808168 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022599
protein coding gene Chr17:44275801-44286789 (-)
WSB/EiJ MGP_WSBEiJ_G0023104
protein coding gene Chr17:47949104-47957368 (-)



Homology
more
  • Human Ortholog
    PTCRA, pre T cell antigen receptor alpha
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PTCRA, pre T cell antigen receptor alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PTA, PT-ALPHA
  • Links
    NCBI Gene ID: 171558
    neXtProt AC: NX_Q6ISU1
    UniProt: Q6ISU1

  • Chr Location
    6p21.1; chr6:42915989-42925838 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 4 alleles in 5 genetic backgrounds
    4 phenotypes from multigenic genotypes
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a knock-out allele show thymus hypoplasia, arrested T cell differentiation, decreased DN4 cell number, and increased DN3 T cell number. Homozygotes for a knock-in allele show decreased double-positive T cell count, increased DN3 number, and increased gamma-delta T cell number.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19208 NCBI Gene Model | MGI Sequence Detail 8050 C57BL/6J ±  kb
    transcript NM_011195 RefSeq | MGI Sequence Detail 1283 Not Specified  
    polypeptide P0C6B2 UniProt | EBI | MGI Sequence Detail 199 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR027834 Pre-T-cell antigen receptor
    Molecular
    Reagents
    less
    • All nucleic 11
      Genomic 3
      cDNA 7
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-28154
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 55
    • Earliest
      J:39556 Kishi H, et al., Surface expression of the beta T cell receptor (TCR) chain in the absence of other TCR or CD3 proteins on immature T cells. EMBO J. 1991 Jan;10(1):93-100
    • Latest
      J:275319 Klein F, et al., The transcription factor Duxbl mediates elimination of pre-T cells that fail beta-selection. J Exp Med. 2019 Mar 4;216(3):638-655

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory