Cd55 MGI Mouse Gene Detail - MGI:104850 - CD55 molecule, decay accelerating factor for complement

Cd55 Gene Detail

Symbol

Cd55
Name

CD55 molecule, decay accelerating factor for complement
Synonyms

complement-glycosylphosphatidylinositol, Cromer blood group, Daf1, Daf-GPI, GPI-DAF

Feature Type

protein coding gene
IDs

MGI:104850
NCBI Gene: 13136
Gene Overview

MyGene.info: CD55
Alliance

gene page

Sequence Map

Chr1:130439027-130462744 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

23718 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 56.89 cM
Mapping Data

6 experiments

Human Ortholog

CD55, CD55 molecule (Cromer blood group)

Vertebrate Orthologs

8

Human Ortholog

CD55, CD55 molecule (Cromer blood group)
Orthology source: HomoloGene, HGNC
Synonyms

CHAPLE, CR, CROM, DAF, TC
Links

HGNC:2665

NCBI Gene ID: 1604

neXtProt AC: NX_P08174

UniProt: P08174
Chr Location

1q32.2; chr1:207321472-207360966 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 479
1 human;2 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 macaque, rhesus
HCOP

human homology predictions: CD55
Protein SuperFamily

decay-accelerating factor DAF (CD55 antigen)
Gene Tree

Cd55

Diseases

1 with human CD55 associations

				Human Disease	Mouse Models
				protein-losing enteropathy IDs protein-losing enteropathy DOID:10611 MESH:D011504 OMIM:226300 UMLS_CUI:C0033680

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

10 phenotypes from 2 alleles in 4 genetic backgrounds
9 phenotypes from multigenic genotypes
57 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

2
Radiation induced

1
Targeted

5
Transgenic

1
Genomic Mutations

3 involving Cd55
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

28 strains or lines available

Homozygous mutant mice show increased susceptibility to injury following ethanol exposure, to experimental autoimmune myasthenia gravis and to acute nephrotoxic nephritis. Another allele results in an abnormal complement cascade leading to increased C3 deposition.

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All GO Annotations

14
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

52
Tissues

47
cDNA Data

21
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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Cd55 interacts with 228 markers (Mir7-1, Mir9-1, Mir9-2, ...) View All

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All Sequences

50
RefSeq

12
UniProt

3
CCDS

CCDS15256.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000025169	VEGA Gene Model \| MGI Sequence Detail	23718	C57BL/6J	± kb
transcript	OTTMUST00000061930	VEGA \| MGI Sequence Detail	2533	Not Applicable
polypeptide	OTTMUSP00000030472	VEGA \| MGI Sequence Detail	390	Not Applicable

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SNPs within 2kb

182 from dbSNP Build 142

RFLP

1

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UniProt

3 Sequences
InterPro Domains

IPR000436 Sushi/SCR/CCP domain

IPR035976 Sushi/SCR/CCP superfamily

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All nucleic 24

Genomic 1

cDNA 22

Primer pair 1

Microarray probesets 8

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MGD-MRK-28146

Summaries

All 93

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 57
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:230770 Yu M, et al., Deficiency of CC chemokine ligand 2 and decay-accelerating factor causes retinal degeneration in mice. Exp Eye Res. 2015 Sep;138:126-33

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 06/12/2018 MGI 6.12