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Cd55 Gene Detail
Summary
  • Symbol
    Cd55
  • Name
    CD55 molecule, decay accelerating factor for complement
  • Synonyms
    complement-glycosylphosphatidylinositol, Cromer blood group, Daf1, Daf-GPI, GPI-DAF
  • Feature Type
    protein coding gene
  • IDs
    MGI:104850
    NCBI Gene: 13136
  • Gene Overview
    MyGene.info: CD55
Location & Maps
more
  • Sequence Map
    Chr1:130439027-130462744 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23718 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 56.89 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    CD55, CD55 molecule (Cromer blood group)
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CD55, CD55 molecule (Cromer blood group)
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CR, CROM, DAF, TC
  • Links
    NCBI Gene ID: 1604
    neXtProt AC: NX_P08174

  • Chr Location
    1q32; chr1:207321472-207360966 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 4 genetic backgrounds
    9 phenotypes from multigenic genotypes
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    5
  • Transgenic
    1
  • Genomic Mutations
    3 involving Cd55
  • Incidental Mutations
Homozygous mutant mice show increased susceptibility to injury following ethanol exposure, to experimental autoimmune myasthenia gravis and to acute nephrotoxic nephritis. Another allele results in an abnormal complement cascade leading to increased C3 deposition.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Other Mouse Links
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025169 VEGA Gene Model | MGI Sequence Detail 23718 C57BL/6J ±  kb
transcript OTTMUST00000061930 VEGA | MGI Sequence Detail 2533 Not Applicable  
polypeptide OTTMUSP00000030472 VEGA | MGI Sequence Detail 390 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    182 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR000436 Sushi/SCR/CCP domain
Molecular
Reagents
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  • All nucleic 24
    Genomic 1
    cDNA 22
    Primer pair 1

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-28146
References
more
  • Summaries
    All 85
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 57
  • Earliest
    J:29133 Spicer AP, et al., Molecular cloning and chromosomal localization of the mouse decay-accelerating factor genes. Duplicated genes encode glycosylphosphatidylinositol-anchored and transmembrane forms. J Immunol. 1995 Sep 15;155(6):3079-91
  • Latest
    J:230770 Yu M, et al., Deficiency of CC chemokine ligand 2 and decay-accelerating factor causes retinal degeneration in mice. Exp Eye Res. 2015 Sep;138:126-33

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory