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Cd55
Gene Detail
Symbol

Name
ID
Cd55
CD55 antigen
MGI:104850
Synonyms
complement-glycosylphosphatidylinositol, Cromer blood group, Daf1, Daf-GPI, GPI-DAF
Feature Type
protein coding gene
Genetic Map
Chromosome 1
56.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr1:130439027-130462744 bp, - strand
From VEGA annotation of GRCm38

  23718 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:479  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: decay-accelerating factor DAF (CD55 antigen)
Gene Tree: Cd55

Human
homologs
Human Homolog CD55, CD55 molecule, decay accelerating factor for complement (Cromer blood group)
NCBI Gene ID 1604
neXtProt AC  NX_P08174
Human Synonyms  CR, CROM, DAF, TC
Human Chr (Location)  1q32; chr1:207321472-207360966 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice show increased susceptibility to injury following ethanol exposure, to experimental autoimmune myasthenia gravis and to acute nephrotoxic nephritis. Another allele results in an abnormal complement cascade leading to increased C3 deposition.
 
Interactions
Cd55 interacts with 228 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process complement activation, classical pathway, immune system process, ...
Component anchored component of membrane, apical plasma membrane, ...
Function enzyme inhibitor activity, lipid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (52)    Tissues (47)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RT-PCR 46
cDNA source data(20)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(23) Genomic(1) cDNA(21) Primer pair(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000025169 (Evidence)
Ensembl Gene ModelENSMUSG00000026399 (Evidence)
Entrez Gene13136 (Evidence)
DFCITC1624059, TC1581400, TC1682513, TC1716341, TC1705753
Consensus CDS ProjectCCDS15256.1
International Mouse Knockout Project StatusCd55
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025169 VEGA Gene Model | MGI Sequence Detail 23718 C57BL/6J ±  kb
transcript OTTMUST00000061930 VEGA | MGI Sequence Detail 2533 Not Applicable 
polypeptide OTTMUSP00000030472 VEGA | MGI Sequence Detail 390 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(10) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(212 from dbSNP Build 137)    SNPs within 2kb including multiple locations(260)
Protein-related
information
ResourceIDDescription
InterPro IPR000436 Sushi/SCR/CCP
Protein Ontology PR:000025662 complement decay-accelerating factor
References
(Earliest) J:29133 Spicer AP, et al., Molecular cloning and chromosomal localization of the mouse decay-accelerating factor genes. Duplicated genes encode glycosylphosphatidylinositol-anchored and transmembrane forms. J Immunol. 1995 Sep 15;155(6):3079-91
(Latest) J:204834 van der Touw W, et al., Cutting edge: Receptors for C3a and C5a modulate stability of alloantigen-reactive induced regulatory T cells. J Immunol. 2013 Jun 15;190(12):5921-5
All references(84)
Other
accession IDs
MGD-MRK-28146

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory