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Cd55 Gene Detail
Summary
  • Symbol
    Cd55
  • Name
    CD55 molecule, decay accelerating factor for complement
  • Synonyms
    complement-glycosylphosphatidylinositol, Cromer blood group, Daf1, Daf-GPI, GPI-DAF
  • Feature Type
    protein coding gene
  • IDs
    MGI:104850
    NCBI Gene: 13136
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:130366764-130390481 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 56.89 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    378 from dbSNP Build 142
  • Strain Annotations
    15
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104850
 protein coding gene Chr1:130357526-130390513 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016434
 protein coding gene Chr1:133822616-133851431 (-)
A/J MGP_AJ_G0016417
 protein coding gene Chr1:128865409-128894181 (-)
AKR/J MGP_AKRJ_G0016382
 protein coding gene Chr1:132628902-132698680 (-)
BALB/cJ MGP_BALBcJ_G0016377
 protein coding gene Chr1:129114678-129230238 (-)
C3H/HeJ MGP_C3HHeJ_G0016203
 protein coding gene Chr1:132804021-132838980 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016837
 protein coding gene Chr1:138712873-138818146 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014552
 protein coding gene Chr1:121967435-122058116 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0016175
 protein coding gene Chr1:143559020-143614590 (-)
DBA/2J MGP_DBA2J_G0016282
 protein coding gene Chr1:127834157-127864649 (-)
FVB/NJ MGP_FVBNJ_G0016281
 protein coding gene Chr1:126470433-126508380 (-)
LP/J MGP_LPJ_G0016353
 protein coding gene Chr1:135081821-135167999 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016305
 protein coding gene Chr1:149284784-149397284 (-)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0015569
 protein coding gene Chr1:126748127-126781355 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0015845
 protein coding gene Chr1:132310579-132399997 (-)



Homology
more
  • Human Ortholog
    CD55, CD55 molecule (Cromer blood group)
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD55, CD55 molecule (Cromer blood group)
  • Synonyms
    CHAPLE, CR, CROM, DAF, TC
  • Links
    NCBI Gene ID: 1604
    UniProt: P08174

  • Chr Location
    1q32.2; chr1:207321519-207386804 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CD55 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 3 alleles in 5 genetic backgrounds
    9 phenotypes from multigenic genotypes
    73 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice show increased susceptibility to injury following ethanol exposure, to experimental autoimmune myasthenia gravis and to acute nephrotoxic nephritis. Another allele results in an abnormal complement cascade leading to increased C3 deposition.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    775
  • Tissues
    56
  • cDNA Data
    22
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026399 Ensembl Gene Model | MGI Sequence Detail 23718 C57BL/6J ±  kb
    transcript ENSMUST00000027650 Ensembl | MGI Sequence Detail 2533 Not Applicable  
    polypeptide ENSMUSP00000027650 Ensembl | MGI Sequence Detail 390 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR050350 Complement & Cell Adhesion Regulators
      IPR000436 Sushi/SCR/CCP domain
      IPR035976 Sushi/SCR/CCP superfamily
    • GlyGen
      Q61475 4 sites, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 1
      cDNA 23
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-28146
    References
    more
    • Summaries
      All 117
      Developmental Gene Expression 5
      Gene Ontology 10
      Phenotypes 73
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:363617 Hsu AY, et al., Neutrophil-derived vesicles control complement activation to facilitate inflammation resolution. Cell. 2025 Mar 20;188(6):1623-1641.e26
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory