Cd55
Gene Detail

Symbol Name ID

Cd55 CD55 antigen MGI:104850

Synonyms

complement-glycosylphosphatidylinositol, Cromer blood group, Daf1, Daf-GPI, GPI-DAF

Feature Type

protein coding gene

Genetic Map

Chromosome 1

56.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr1:130439027-130462744 bp, - strand From VEGA annotation of GRCm38   23718 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:479  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: decay-accelerating factor DAF (CD55 antigen)
Gene Tree: Cd55

Human homologs

Human Homolog		CD55, CD55 molecule, decay accelerating factor for complement (Cromer blood group)
NCBI Gene ID		1604
neXtProt AC		NX_P08174
Human Synonyms		CR, CROM, DAF, TC
Human Chr (Location)		1q32; chr1:207321472-207360966 (+)  GRCh38

Alleles and phenotypes

All alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous mutant mice show increased susceptibility to injury following ethanol exposure, to experimental autoimmune myasthenia gravis and to acute nephrotoxic nephritis. Another allele results in an abnormal complement cascade leading to increased C3 deposition.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	complement activation, classical pathway, immune system process, ...
Component	anchored component of membrane, apical plasma membrane, ...
Function	enzyme inhibitor activity, lipid binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)

Data Summary: Results (52)    Tissues (47)    Images (1)
Theiler Stages: 17, 23, 28

Assay Type	Results
Immunohistochemistry	6
RT-PCR	46

cDNA source data(20)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(23) Genomic(1) cDNA(21) Primer pair(1)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000025169 (Evidence)
Ensembl Gene Model	ENSMUSG00000026399 (Evidence)
Entrez Gene	13136 (Evidence)
DFCI	TC1581400, TC1624059, TC1682513, TC1705753, TC1716341
DoTS	DT.101324108, DT.101370688, DT.110933568, DT.91572708, DT.94208342, DT.94208343, DT.94208368
Consensus CDS Project	CCDS15256.1
International Mouse Knockout Project Status	Cd55

Sequences

Length	Strain/Species
genomic	OTTMUSG00000025169	VEGA Gene Model | MGI Sequence Detail	23718	C57BL/6J
transcript	OTTMUST00000061930	VEGA | MGI Sequence Detail	2533	Not Applicable
polypeptide	OTTMUSP00000030472	VEGA | MGI Sequence Detail	390	Not Applicable

All sequences(57) RefSeq(10) UniProt(2)

Polymorphisms

RFLP(1) : SNPs within 2kb(212 from dbSNP Build 137)    SNPs within 2kb including multiple locations(260)

Protein-related information

Resource	ID	Description
InterPro	IPR000436	Sushi/SCR/CCP
Protein Ontology	PR:000025662	complement decay-accelerating factor

References

(Earliest) J:29133 Spicer AP, et al., Molecular cloning and chromosomal localization of the mouse decay-accelerating factor genes. Duplicated genes encode glycosylphosphatidylinositol-anchored and transmembrane forms. J Immunol. 1995 Sep 15;155(6):3079-91
(Latest) J:204834 van der Touw W, et al., Cutting edge: Receptors for C3a and C5a modulate stability of alloantigen-reactive induced regulatory T cells. J Immunol. 2013 Jun 15;190(12):5921-5
All references(85)

Other accession IDs

MGD-MRK-28146