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Cpox Gene Detail
Summary
  • Symbol
    Cpox
  • Name
    coproporphyrinogen oxidase
  • Synonyms
    cac, clone 560, Cpo, nct
  • Feature Type
    protein coding gene
  • IDs
    MGI:104841
    NCBI Gene: 12892
  • Gene Overview
    MyGene.info: CPOX
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr16:58670208-58680391 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      10184 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 34.80 cM, cytoband C1.1
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    CPOX, coproporphyrinogen oxidase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CPOX, coproporphyrinogen oxidase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    COX, CPO, CPX, HCP
  • Links
    NCBI Gene ID: 1371
    neXtProt AC: NX_P36551
    UniProt: P36551

  • Chr Location
    3q11.2; chr3:98568448-98593684 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Cpox mouse models; 1 with human CPOX associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous allele develop cataracts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    97
  • Tissues
    97
  • cDNA Data
    57
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12892 NCBI Gene Model | MGI Sequence Detail 10184 C57BL/6J ±  kb
    transcript NM_007757 RefSeq | MGI Sequence Detail 3186 C57BL/6  
    polypeptide P36552 UniProt | EBI | MGI Sequence Detail 443 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      142 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000005826 oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial
      (term hierarchy)
    • EC
      1.3.3.3
    • InterPro Domains
      IPR001260 Coproporphyrinogen III oxidase, aerobic
      IPR018375 Coproporphyrinogen III oxidase, conserved site
      IPR036406 Oxygen-dependent coproporphyrinogen III oxidase superfamily
    Molecular
    Reagents
    less
    • All nucleic 60
      Genomic 2
      cDNA 58

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12796, MGD-MRK-28136, MGI:97287
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 10
      Phenotypes 12
    • Earliest
      J:155095 Nakano K, et al., Hereditary Cataract in Mice. Jap J Clin Opthalmol. 1960;14:194-200
    • Latest
      J:244493 Conway AJ, et al., A mouse model of hereditary coproporphyria identified in an ENU mutagenesis screen. Dis Model Mech. 2017 Aug 01;10(8):1005-1013
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/12/2018
    MGI 6.12     		The Jackson Laboratory