Cpox
Gene Detail

Symbol Name ID

Cpox coproporphyrinogen oxidase MGI:104841

Synonyms

clone 560, Cpo

Feature Type

protein coding gene

Genetic Map

Chromosome 16

34.80 cM, cytoband C1.1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr16:58670208-58680391 bp, + strand From NCBI annotation of GRCm38   10184 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:76  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: coproporphyrinogen oxidase
Gene Tree: Cpox

Human homologs

Human Homolog		CPOX, coproporphyrinogen oxidase
NCBI Gene ID		1371
neXtProt AC		NX_P36551
Human Synonyms		CPO, CPX, HCP
Human Chr (Location)		3q12; chr3:98298290-98312455 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CPOX

Alleles and phenotypes

All alleles(2) : Targeted(2)

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	heme biosynthetic process, oxidation-reduction process, ...
Component	cytoplasm, mitochondrial inner membrane, ...
Function	coproporphyrinogen oxidase activity, identical protein binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (97)    Tissues (97)    Images (1)
Theiler Stages: 13, 14, 22

Assay Type	Results
RNA in situ	94
Northern blot	3

cDNA source data(57)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(60) Genomic(2) cDNA(58)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000022742 (Evidence)
Entrez Gene	12892 (Evidence)
UniGene	291519
DFCI	TC1575851
DoTS	DT.55282308, DT.87044266
NIA Mouse Gene Index	U017228
EC	1.3.3.3
Consensus CDS Project	CCDS49878.1
International Mouse Knockout Project Status	Cpox

Sequences

Length	Strain/Species
genomic	12892	NCBI Gene Model | MGI Sequence Detail	10184	C57BL/6J
transcript	NM_007757	RefSeq | MGI Sequence Detail	3186	C57BL/6
polypeptide	P36552	UniProt | EBI | MGI Sequence Detail	443	Not Applicable

All sequences(22) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(65 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001260	Coproporphyrinogen III oxidase, aerobic
InterPro	IPR018375	Coproporphyrinogen III oxidase, conserved site
Protein Ontology	PR:000005826	coproporphyrinogen-III oxidase, mitochondrial

Graphical View of Protein Domain Structure

References

(Earliest) J:30047 Kohno H, et al., Coproporphyrinogen oxidase. Purification, molecular cloning, and induction of mRNA during erythroid differentiation. J Biol Chem. 1993 Oct 5;268(28):21359-63
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(40)

Other accession IDs

MGD-MRK-28136