Cpox
Gene Detail

Symbol

Name
ID

Cpox
coproporphyrinogen oxidase
MGI:104841

Synonyms

cac, clone 560, Cpo, nct

Feature Type

protein coding gene

Genetic Map

Chromosome 16
34.80 cM, cytoband C1.1
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr16:58670208-58680391 bp, + strand From NCBI annotation of GRCm38   10184 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:76  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: coproporphyrinogen oxidase
Gene Tree: Cpox

Human
homologs

Human Homolog		CPOX, coproporphyrinogen oxidase
NCBI Gene ID		1371
neXtProt AC		NX_P36551
Human Synonyms		CPO, CPX, HCP
Human Chr (Location)		3q12; chr3:98577836-98593624 (-)  GRCh38
Disease Associations		(1) Diseases Associated with Human CPOX

Mutations,
alleles, and
phenotypes

All mutations/alleles(3) : Spontaneous(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a spontaneous allele develop cataracts.

 
Human Diseases Modeled in Mice Using Cpox (1)    Mutations Annotated to Human Diseases (1)   

Interactions

Cpox interacts with 193 markers (Mir7-1, Mir7-2, Mir7b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (24 annotations)

Process	ATP catabolic process, heme biosynthetic process, ...
Component	cytoplasm, mitochondrial inner membrane, ...
Function	coproporphyrinogen oxidase activity, identical protein binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (5 records)

Data Summary: Results (97)    Tissues (97)    Images (1)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	94
Northern blot	3

cDNA source data(57)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(60) Genomic(2) cDNA(58)
Microarray probesets(5)

Other database
links

Ensembl Gene Model	ENSMUSG00000022742 (Evidence)
Entrez Gene	12892 (Evidence)
UniGene	291519
DFCI	TC1575851
DoTS	DT.87044266, DT.55282308
NIA Mouse Gene Index	U017228
EC	1.3.3.3
Consensus CDS Project	CCDS49878.1
International Mouse Knockout Project Status	Cpox

Sequences

Length	Strain/Species
genomic	12892	NCBI Gene Model | MGI Sequence Detail	10184	C57BL/6J
transcript	NM_007757	RefSeq | MGI Sequence Detail	3186	C57BL/6
polypeptide	P36552	UniProt | EBI | MGI Sequence Detail	443	Not Applicable

All sequences(23) RefSeq(2) UniProt(3)

Polymorphisms

SNPs within 2kb(142 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR001260	Coproporphyrinogen III oxidase, aerobic
InterPro	IPR018375	Coproporphyrinogen III oxidase, conserved site
Protein Ontology	PR:000005826	coproporphyrinogen-III oxidase, mitochondrial

Graphical View of Protein Domain Structure

References

(Earliest) J:155095 Nakano K, et al., Hereditary Cataract in Mice. Jap J Clin Opthalmol. 1960;14:194-200
(Latest) J:196645 Mori M, et al., Hereditary cataract of the Nakano mouse: Involvement of a hypomorphic mutation in the coproporphyrinogen oxidase gene. Exp Eye Res. 2013 Apr 28;112C:45-50
All references(51)
Disease annotation references (1)

Other
accession IDs

MGD-MRK-12796, MGD-MRK-28136, MGI:97287