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Cpox
Gene Detail
 Symbol
Name
ID
Cpox
coproporphyrinogen oxidase
MGI:104841
Synonyms cac, clone 560, Cpo, nct
Feature Type protein coding gene
Genetic Map
Chromosome 16
34.80 cM, cytoband C1.1
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr16:58670208-58680391 bp, + strand
From NCBI annotation of GRCm38

  10184 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:76  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: coproporphyrinogen oxidase
Gene Tree: Cpox

Human
homologs
Human Homolog CPOX, coproporphyrinogen oxidase
NCBI Gene ID 1371
neXtProt AC  NX_P36551
Human Synonyms  CPO, CPX, HCP
Human Chr (Location)  3q12; chr3:98577836-98593624 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CPOX
Alleles
and
phenotypes
All alleles(3) : Spontaneous(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a spontaneous allele develop cataracts.
 
Human Diseases Modeled Using Mouse Cpox (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process ATP catabolic process, heme biosynthetic process, ...
Component mitochondrial inner membrane, mitochondrial intermembrane space, ...
Function coproporphyrinogen oxidase activity, identical protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (97)    Tissues (97)    Images (1)
Theiler Stages: 13, 14, 22
Assay TypeResults
RNA in situ 94
Northern blot 3
cDNA source data(57)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(60) Genomic(2) cDNA(58)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000022742 (Evidence)
Entrez Gene12892 (Evidence)
UniGene291519
DFCITC1575851
DoTSDT.55282308, DT.87044266
NIA Mouse Gene IndexU017228
EC1.3.3.3
Consensus CDS ProjectCCDS49878.1
International Mouse Knockout Project StatusCpox
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12892 NCBI Gene Model | MGI Sequence Detail 10184 C57BL/6J ±  kb
transcript NM_007757 RefSeq | MGI Sequence Detail 3186 C57BL/6 
polypeptide P36552 UniProt | EBI | MGI Sequence Detail 443 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(142 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001260 Coproporphyrinogen III oxidase, aerobic
InterPro IPR018375 Coproporphyrinogen III oxidase, conserved site
Protein Ontology PR:000005826 coproporphyrinogen-III oxidase, mitochondrial
Graphical View of Protein Domain Structure
References (Earliest) J:155095 Nakano K, et al., Hereditary Cataract in Mice. Jap J Clin Opthalmol. 1960;14:194-200
(Latest) J:196645 Mori M, et al., Hereditary cataract of the Nakano mouse: Involvement of a hypomorphic mutation in the coproporphyrinogen oxidase gene. Exp Eye Res. 2013 Apr 28;112C:45-50
All references(51)
Other
accession IDs
MGD-MRK-12796, MGD-MRK-28136, MGI:97287

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory