About   Help   FAQ
Cpox Gene Detail
Summary
  • Symbol
    Cpox
  • Name
    coproporphyrinogen oxidase
  • Synonyms
    cac, clone 560, Cpo, M100835, nct
  • Feature Type
    protein coding gene
  • IDs
    MGI:104841
    NCBI Gene: 12892
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:58490571-58500754 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16,
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    345 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104841
 protein coding gene Chr16:58490571-58537999 (+)
129S1/SvImJ ENSMUSG00200020537
 protein coding gene Chr16:55367843-55378962 (+)
A/J ENSMUSG00195024908
 protein coding gene Chr16:55012282-55022386 (+)
AKR/J ENSMUSG00220019029
 protein coding gene Chr16:55388923-55399019 (+)
BALB/cJ ENSMUSG00180023094
 protein coding gene Chr16:55184355-55194455 (+)
C3H/HeJ ENSMUSG00175015940
 protein coding gene Chr16:55472905-55482997 (+)
C57BL/6NJ ENSMUSG00215012754
 protein coding gene Chr16:55297620-55307716 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020831
 protein coding gene Chr16:54916823-54927033 (+)
CAST/EiJ ENSTCUG00005013286
 protein coding gene Chr16:55453682-55463730 (+)
CBA/J ENSMUSG00210019067
 protein coding gene Chr16:55459952-55469997 (+)
DBA/2J ENSMUSG00185024516
 protein coding gene Chr16:55361798-55371899 (+)
FVB/NJ ENSMUSG00205009987
 protein coding gene Chr16:55127362-55138490 (+)
JF1/MsJ ENSUMUG00000015225
 protein coding gene Chr16:55608196-55618250 (+)
LP/J ENSMUSG00230007216
 protein coding gene Chr16:57896596-57907719 (+)
NOD/ShiLtJ ENSMUSG00190007240
 protein coding gene Chr16:55395111-55405202 (+)
NZO/HlLtJ ENSMUSG00225035655
 protein coding gene Chr16:61026596-61036691 (+)
PWK/PhJ ENSLUMG00010011325
 protein coding gene Chr16:55356356-55366404 (+)
SPRET/EiJ ENSMSPG00010001554
 protein coding gene Chr16:55870611-55879445 (+)
WSB/EiJ ENSIUOG00005008186
 protein coding gene Chr16:55566946-55577037 (+)



Homology
more
  • Human Ortholog
    CPOX, coproporphyrinogen oxidase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CPOX, coproporphyrinogen oxidase
  • Synonyms
    COX, CPO, CPX, HARPO, HCP
  • Links
    NCBI Gene ID: 1371
    UniProt: P36551

  • Chr Location
    3q11.2; chr3:98570488-98593707 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cpox mouse models; 2 with human CPOX associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 4 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous allele develop cataracts. Mice homozygous for an ENU-induced allele have reduced mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) and increased red blood cell volume distribution width (RDW).
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    698
  • Tissues
    98
  • cDNA Data
    58
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12892 NCBI Gene Model | MGI Sequence Detail 10184 C57BL/6J ±  kb
    transcript NM_007757 RefSeq | MGI Sequence Detail 3186 ZRU/MplStud  
    polypeptide P36552 UniProt | EBI | MGI Sequence Detail 443 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000005826 oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial
      (term hierarchy)
    • EC
      1.3.3.3
    • InterPro Domains
      IPR001260 Coproporphyrinogen III oxidase, aerobic
      IPR018375 Coproporphyrinogen III oxidase, conserved site
      IPR036406 Oxygen-dependent coproporphyrinogen III oxidase superfamily
    • GlyGen
      P36552 2 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 63
      Genomic 2
      cDNA 59
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12796, MGD-MRK-28136, MGI:3807240, MGI:97287
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 5
      Diseases 2
      Gene Ontology 18
      Phenotypes 25
    • Earliest
      J:155095 Nakano K, et al., Hereditary Cataract in Mice. Jap J Clin Opthalmol. 1960;14:194-200
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory