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Amz2 Gene Detail
Summary
  • Symbol
    Amz2
  • Name
    archaelysin family metallopeptidase 2
  • Synonyms
    ESTM12
  • Feature Type
    protein coding gene
  • IDs
    MGI:104837
    NCBI Gene: 13929
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:109316772-109328974 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 71.89 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    460 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104837
 protein coding gene Chr11:109316772-109343639 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019333
 protein coding gene Chr11:112983405-113016476 (+)
A/J MGP_AJ_G0019301
 protein coding gene Chr11:108095319-108122749 (+)
AKR/J MGP_AKRJ_G0019270
 protein coding gene Chr11:111333828-111364316 (+)
BALB/cJ MGP_BALBcJ_G0019275
 protein coding gene Chr11:108527140-108554727 (+)
C3H/HeJ MGP_C3HHeJ_G0019084
 protein coding gene Chr11:111642920-111671529 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019725
 protein coding gene Chr11:116405526-116438231 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017348
 protein coding gene Chr11:105324916-105352749 (+)
CAST/EiJ MGP_CASTEiJ_G0018637
 protein coding gene Chr11:112760538-112801441 (+)
CBA/J MGP_CBAJ_G0019053
 protein coding gene Chr11:121215315-121249184 (+)
DBA/2J MGP_DBA2J_G0019165
 protein coding gene Chr11:107573115-107601014 (+)
FVB/NJ MGP_FVBNJ_G0019156
 protein coding gene Chr11:107062948-107089985 (+)
LP/J MGP_LPJ_G0019235
 protein coding gene Chr11:113393487-113424449 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019187
 protein coding gene Chr11:120362552-120395053 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019762
 protein coding gene Chr11:111901858-111930098 (+)
PWK/PhJ MGP_PWKPhJ_G0018402
 protein coding gene Chr11:108734798-108764399 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018193
 protein coding gene Chr11:111675011-111716023 (+)
WSB/EiJ MGP_WSBEiJ_G0018689
 protein coding gene Chr11:111824179-111858764 (+)



Homology
more
  • Human Ortholog
    AMZ2, archaelysin family metallopeptidase 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AMZ2, archaelysin family metallopeptidase 2
  • Links
    NCBI Gene ID: 51321
    UniProt: Q86W34

  • Chr Location
    17q24.2; chr17:68205481-68257712 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    782
  • Tissues
    14
  • cDNA Data
    16
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 13929 NCBI Gene Model | MGI Sequence Detail 12203 C57BL/6J ±  kb
transcript NM_001252193 RefSeq | MGI Sequence Detail 2997 C57BL/6NCrl  
polypeptide Q400C8 UniProt | EBI | MGI Sequence Detail 359 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 16

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-28131, MGI:2143982
References
more
  • Summaries
    All 37
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:28401 Bettenhausen B, et al., Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/24/2026
MGI 6.24 		The Jackson Laboratory