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Amz2 Gene Detail
Summary
  • Symbol
    Amz2
  • Name
    archaelysin family metallopeptidase 2
  • Synonyms
    ESTM12
Location &
Maps
more
  • Sequence Map
    Chr11:109425946-109452813 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 71.89 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    121 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104837
protein coding gene Chr11:109425946-109453359 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019333
protein coding gene Chr11:112983405-113016476 (+)
A/J MGP_AJ_G0019301
protein coding gene Chr11:108095319-108122749 (+)
AKR/J MGP_AKRJ_G0019270
protein coding gene Chr11:111333828-111364316 (+)
BALB/cJ MGP_BALBcJ_G0019275
protein coding gene Chr11:108527140-108554727 (+)
C3H/HeJ MGP_C3HHeJ_G0019084
protein coding gene Chr11:111642920-111671529 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019725
protein coding gene Chr11:116405526-116438231 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017348
protein coding gene Chr11:105324916-105352749 (+)
CAST/EiJ MGP_CASTEiJ_G0018637
protein coding gene Chr11:112760538-112801441 (+)
CBA/J MGP_CBAJ_G0019053
protein coding gene Chr11:121215315-121249184 (+)
DBA/2J MGP_DBA2J_G0019165
protein coding gene Chr11:107573115-107601014 (+)
FVB/NJ MGP_FVBNJ_G0019156
protein coding gene Chr11:107062948-107089985 (+)
LP/J MGP_LPJ_G0019235
protein coding gene Chr11:113393487-113424449 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019187
protein coding gene Chr11:120362552-120395053 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019762
protein coding gene Chr11:111901858-111930098 (+)
PWK/PhJ MGP_PWKPhJ_G0018402
protein coding gene Chr11:108734798-108764399 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018193
protein coding gene Chr11:111675011-111716023 (+)
WSB/EiJ MGP_WSBEiJ_G0018689
protein coding gene Chr11:111824179-111858764 (+)



Homology
more
  • Human Ortholog
    AMZ2, archaelysin family metallopeptidase 2
  • Human Ortholog
    AMZ2, archaelysin family metallopeptidase 2
    Orthology source: HGNC
  • Links
    NCBI Gene ID: 51321
    neXtProt AC: NX_Q86W34
    UniProt: Q86W34

  • Chr Location
    17q24.2; chr17:68205486-68257164 (+)  GRCh38.p7

  • HCOP
    human homology predictions: AMZ2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020610 Ensembl Gene Model | MGI Sequence Detail 26868 C57BL/6J ±  kb
transcript ENSMUST00000103061 Ensembl | MGI Sequence Detail 1832 Not Applicable  
polypeptide ENSMUSP00000099350 Ensembl | MGI Sequence Detail 363 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • EC
  • InterPro Domains
    IPR024079 Metallopeptidase, catalytic domain superfamily
    IPR012962 Peptidase M54, archaemetzincin
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-28131, MGI:2143982
References
more
  • Summaries
    All 32
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:28401 Bettenhausen B, et al., Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/11/2018
MGI 6.13
The Jackson Laboratory