About   Help   FAQ
Hnrnpa1 Gene Detail
Summary
  • Symbol
    Hnrnpa1
  • Name
    heterogeneous nuclear ribonucleoprotein A1
  • Synonyms
    D15Ertd119e, Hdp, hnrnp-A, Hnrpa1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104820
    NCBI Gene: 15382
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:103240432-103246692 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 58.58 cM, cytoband F3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    40 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104820
protein coding gene Chr15:103240397-103246698 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022435
protein coding gene Chr15:105492609-105497212 (+)
A/J MGP_AJ_G0022397
protein coding gene Chr15:101322619-101326663 (+)
AKR/J MGP_AKRJ_G0022372
protein coding gene Chr15:104394714-104401020 (+)
BALB/cJ MGP_BALBcJ_G0022401
protein coding gene Chr15:101369189-101371099 (+)
C3H/HeJ MGP_C3HHeJ_G0022168
protein coding gene Chr15:104488907-104497626 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022850
protein coding gene Chr15:109380121-109385930 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020373
protein coding gene Chr15:97086024-97090606 (+)
CAST/EiJ MGP_CASTEiJ_G0021694
protein coding gene Chr15:105360818-105366547 (+)
CBA/J MGP_CBAJ_G0022137
protein coding gene Chr15:113231080-113235139 (+)
DBA/2J MGP_DBA2J_G0022268
protein coding gene Chr15:100595440-100601090 (+)
FVB/NJ MGP_FVBNJ_G0022244
protein coding gene Chr15:99659855-99665370 (+)
LP/J MGP_LPJ_G0022337
protein coding gene Chr15:105639907-105644608 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0022862
protein coding gene Chr15:104438825-104443437 (+)
PWK/PhJ MGP_PWKPhJ_G0021434
protein coding gene Chr15:100776944-100781676 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021266
protein coding gene Chr15:104274977-104282193 (+)
WSB/EiJ MGP_WSBEiJ_G0021744
protein coding gene Chr15:105056027-105062463 (+)



Homology
more
  • Human Ortholog
    HNRNPA1, heterogeneous nuclear ribonucleoprotein A1
  • Vertebrate Orthologs
    3
  • Human Ortholog
    HNRNPA1, heterogeneous nuclear ribonucleoprotein A1
    Orthology source: HGNC
  • Synonyms
    ALS19, ALS20, hnRNP A1, hnRNP-A1, HNRPA1, HNRPA1L3, IBMPFD3, UP 1
  • Links
    NCBI Gene ID: 3178
    neXtProt AC: NX_P09651
    UniProt: P09651

  • Chr Location
    12q13.13; chr12:54280690-54287088 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human HNRNPA1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit prenatal and neonatal lethality, dilated cardiacmyopathy, and hypoplastic tongue and intercostal muscles. Mice heterozygous for a knock-out allele exhibit altered cardiac signaling, increased heart rate and increased systemic arterial systolic blood pressure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046434 Ensembl Gene Model | MGI Sequence Detail 6261 C57BL/6J ±  kb
    transcript ENSMUST00000036004 Ensembl | MGI Sequence Detail 1918 Not Applicable  
    polypeptide ENSMUSP00000042658 Ensembl | MGI Sequence Detail 373 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • InterPro Domains
      IPR034845 hnRNP A1, RNA recognition motif 1
      IPR034803 hnRNP A1, RNA recognition motif 2
      IPR021662 Nuclear factor hnRNPA1
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 2
      cDNA 35
      Primer pair 3
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-26049, MGD-MRK-28114, MGI:104612, MGI:1261777
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 10
      Gene Ontology 8
      Phenotypes 7
    • Earliest
      J:1572 Varmuza S, et al., Isolation of epiblast-specific cDNA clones by differential hybridization with polymerase chain reaction-amplified probes derived from single embryos. Mol Reprod Dev. 1992 Aug;32(4):339-48
    • Latest
      J:262085 Yu Z, et al., Mutations in Hnrnpa1 cause congenital heart defects. JCI Insight. 2018 Jan 25;3(2)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory