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Hnrnpa1 Gene Detail
Summary
  • Symbol
    Hnrnpa1
  • Name
    heterogeneous nuclear ribonucleoprotein A1
  • Synonyms
    D15Ertd119e, Hdp, hnrnp-A, Hnrpa1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104820
    NCBI Gene: 15382
Location & Maps
more
  • Sequence Map
    Chr15:103240432-103244955 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4524 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 58.58 cM, cytoband F3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    HNRNPA1, heterogeneous nuclear ribonucleoprotein A1
  • Vertebrate Orthologs
    3
  • Human Ortholog
    HNRNPA1, heterogeneous nuclear ribonucleoprotein A1
    Orthology source: HGNC
  • Synonyms
    ALS19, ALS20, hnRNP A1, hnRNP-A1, HNRPA1, HNRPA1L3, IBMPFD3, UP 1
  • Links
    NCBI Gene ID: 3178
    neXtProt AC: NX_P09651

  • Chr Location
    12q13.1; chr12:54280696-54287087 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human HNRNPA1 associations

Human Disease Mouse Models
       Amyotrophic Lateral Sclerosis 20; ALS20   OMIM: 615426
Inclusion Body Myopathy with Early-Onset Paget Disease with or without Frontotemporal Dementia 3; IBMPFD3   OMIM: 615424
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
  • All Mutations and Alleles
    36
  • Gene trapped
    34
  • Targeted
    2
  • Incidental Mutations
    APF , CvDC
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046434 Ensembl Gene Model | MGI Sequence Detail 4524 C57BL/6J ±  kb
transcript ENSMUST00000036004 Ensembl | MGI Sequence Detail 1918 Not Applicable  
polypeptide ENSMUSP00000042658 Ensembl | MGI Sequence Detail 373 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    26 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000008658 heterogeneous nuclear ribonucleoprotein A1
  • InterPro Domains
    IPR021662 Nuclear factor hnRNPA1
    IPR012677 Nucleotide-binding alpha-beta plait domain
    IPR000504 RNA recognition motif domain
Molecular
Reagents
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  • All nucleic 40
    Genomic 2
    cDNA 34
    Primer pair 3
    Other 1

    Microarray probesets 8
Other
Accession IDs
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MGD-MRK-26049, MGD-MRK-28114, MGI:104612, MGI:1261777
References
more
  • Summaries
    All 48
    Developmental Gene Expression 7
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:1572 Varmuza S, et al., Isolation of epiblast-specific cDNA clones by differential hybridization with polymerase chain reaction-amplified probes derived from single embryos. Mol Reprod Dev. 1992 Aug;32(4):339-48
  • Latest
    J:208135 Mizutani T, et al., 7SK small nuclear ribonucleoprotein complex is recruited to the HIV-1 promoter via short viral transcripts. FEBS Lett. 2014 May 2;588(9):1630-1636

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory