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Ier3
Gene Detail
Symbol

Name
ID
Ier3
immediate early response 3
MGI:104814
Synonyms
cAMP inducible gene 3, cI-3, gly96, IEX-1
Feature Type
protein coding gene
Genetic Map
Chromosome 17
18.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:35821684-35822923 bp, + strand
From VEGA annotation of GRCm38

  1240 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2894  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Ier3

Human
homologs
Human Homolog IER3, immediate early response 3
NCBI Gene ID 8870
neXtProt AC  NX_P46695
Human Synonyms  DIF2, DIF-2, GLY96, IEX1, IEX-1, IEX-1L, PRG1
Human Chr (Location)  6p21.3; chr6:30743199-30744550 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Genomic Mutations involving Ier3 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for null mutations exhibit elevated systemic arterial pressure. Homozygotes for one null mutation also display cardiac hypertrophy. Homozygotes for a second null mutation display increased susceptibility to parasitic infection.
 
Interactions
Ier3 interacts with 130 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (1)    Tissues (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 1
cDNA source data(122)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(124) Genomic(1) cDNA(122) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037405 (Evidence)
Ensembl Gene ModelENSMUSG00000003541 (Evidence)
Entrez Gene15937 (Evidence)
UniGene25613
DFCITC1601469, TC1574767
DoTSDT.101384121, DT.87051580
NIA Mouse Gene IndexU017917
Consensus CDS ProjectCCDS28704.1
International Mouse Knockout Project StatusIer3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037405 VEGA Gene Model | MGI Sequence Detail 1240 C57BL/6J ±  kb
transcript OTTMUST00000096511 VEGA | MGI Sequence Detail 1131 Not Applicable 
polypeptide OTTMUSP00000053934 VEGA | MGI Sequence Detail 160 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(4 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024829 Radiation-inducible immediate-early gene IEX-1
Protein Ontology PR:000008897 radiation-inducible immediate-early gene IEX-1
References
(Earliest) J:3978 Charles CH, et al., Genomic structure, cDNA sequence, and expression of gly96, a growth factor-inducible immediate-early gene encoding a short-lived glycosylated protein. Oncogene. 1993 Mar;8(3):797-801
(Latest) J:207699 de Laval B, et al., Thrombopoietin promotes NHEJ DNA repair in hematopoietic stem cells through specific activation of Erk and NF-kappaB pathways and their target, IEX-1. Blood. 2014 Jan 23;123(4):509-19
All references(46)
Other
accession IDs
MGD-MRK-28108, MGI:2146916

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory