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Plaa
Gene Detail
 Symbol
Name
ID
Plaa
phospholipase A2, activating protein
MGI:104810
Synonyms D4Ertd618e, Ufd3
Feature Type protein coding gene
Genetic Map
Chromosome 4
43.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:94567514-94603244 bp, - strand
From VEGA annotation of GRCm38

  35731 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3138  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Plaa

Human
homologs
Human Homolog PLAA, phospholipase A2-activating protein
NCBI Gene ID 9373
neXtProt AC  NX_Q9Y263
Human Synonyms  DOA1, PLA2P, PLAP
Human Chr (Location)  9p21; chr9:26903370-26947470 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(18) Targeted(3)
Incidental mutations (data from APF )
Interactions
Plaa interacts with 150 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process inflammatory response, positive regulation of catalytic activity
Component extracellular vesicular exosome
Function phospholipase A2 activator activity, protein binding
External Resources: FuncBase
Expression
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(18) Primer pair(2)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000007850 (Evidence)
Ensembl Gene ModelENSMUSG00000028577 (Evidence)
Entrez Gene18786 (Evidence)
DFCITC1574109, TC1608175, TC1645540, TC1660679, TC1766056
DoTSDT.101166572, DT.493090, DT.60104141, DT.91343893, DT.91400757, DT.94402430, DT.97353229
NIA Mouse Gene IndexU025266
Consensus CDS ProjectCCDS18359.1
International Mouse Knockout Project StatusPlaa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007850 VEGA Gene Model | MGI Sequence Detail 35731 C57BL/6J ±  kb
transcript OTTMUST00000017870 VEGA | MGI Sequence Detail 2784 Not Applicable 
polypeptide OTTMUSP00000008214 VEGA | MGI Sequence Detail 794 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(148 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015155 PLAA family ubiquitin binding, PFU
InterPro IPR013535 PUL
InterPro IPR001680 WD40 repeat
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000012814 phospholipase A-2-activating protein
References (Earliest) J:28587 Clark MA, et al., Cloning of a phospholipase A2-activating protein. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5418-22
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(38)
Other
accession IDs
MGD-MRK-28104, MGI:1277105, MGI:2140330, MGI:2140438, MGI:2140559

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory