Plaa
Gene Detail

Symbol Name ID

Plaa phospholipase A2, activating protein MGI:104810

Synonyms

D4Ertd618e, Ufd3

Feature Type

protein coding gene

Genetic Map

Chromosome 4

43.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr4:94567514-94603244 bp, - strand From VEGA annotation of GRCm38   35731 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3138  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Plaa

Human homologs

Human Homolog		PLAA, phospholipase A2-activating protein
NCBI Gene ID		9373
neXtProt AC		NX_Q9Y263
Human Synonyms		DOA1, PLA2P, PLAP
Human Chr (Location)		9p21; chr9:26903368-26947468 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(21) : Targeted(3) Gene trapped(18)

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Process	inflammatory response, positive regulation of catalytic activity
Component	extracellular vesicular exosome
Function	phospholipase A2 activator activity, protein binding

External Resources: FuncBase

Expression

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) cDNA(18) Primer pair(2)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000007850 (Evidence)
Ensembl Gene Model	ENSMUSG00000028577 (Evidence)
Entrez Gene	18786 (Evidence)
DFCI	TC1574109, TC1608175, TC1645540, TC1660679, TC1766056
DoTS	DT.101166572, DT.493090, DT.60104141, DT.91343893, DT.91400757, DT.94402430, DT.97353229
NIA Mouse Gene Index	U025266
Consensus CDS Project	CCDS18359.1
International Mouse Knockout Project Status	Plaa

Sequences

Length	Strain/Species
genomic	OTTMUSG00000007850	VEGA Gene Model | MGI Sequence Detail	35731	C57BL/6J
transcript	OTTMUST00000017870	VEGA | MGI Sequence Detail	2784	Not Applicable
polypeptide	OTTMUSP00000008214	VEGA | MGI Sequence Detail	794	Not Applicable

All sequences(58) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(105 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015155	PLAA family ubiquitin binding, PFU
InterPro	IPR013535	PUL
InterPro	IPR001680	WD40 repeat
InterPro	IPR017986	WD40-repeat-containing domain
InterPro	IPR015943	WD40/YVTN repeat-like-containing domain
Protein Ontology	PR:000012814	phospholipase A-2-activating protein

References

(Earliest) J:28587 Clark MA, et al., Cloning of a phospholipase A2-activating protein. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5418-22
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(38)

Other accession IDs

MGD-MRK-28104, MGI:1277105, MGI:2140330, MGI:2140438, MGI:2140559