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Plaa Gene Detail
Summary
  • Symbol
    Plaa
  • Name
    phospholipase A2, activating protein
  • Synonyms
    D4Ertd618e, Ufd3
  • Feature Type
    protein coding gene
  • IDs
    MGI:104810
    NCBI Gene: 18786
  • Gene Overview
    MyGene.info: PLAA
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:94567514-94603244 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 43.34 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    148 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104810
protein coding gene Chr4:94565139-94603247 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028450
protein coding gene Chr4:94623947-94659553 (-)
A/J MGP_AJ_G0028413
protein coding gene Chr4:91309037-91344533 (-)
AKR/J MGP_AKRJ_G0028360
protein coding gene Chr4:93474760-93511101 (-)
BALB/cJ MGP_BALBcJ_G0028431
protein coding gene Chr4:91556841-91592806 (-)
C3H/HeJ MGP_C3HHeJ_G0028144
protein coding gene Chr4:94316263-94352924 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028870
protein coding gene Chr4:98232241-98272903 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026164
protein coding gene Chr4:86841864-86876168 (-)
CAST/EiJ MGP_CASTEiJ_G0027584
protein coding gene Chr4:92185741-92222693 (-)
CBA/J MGP_CBAJ_G0028113
protein coding gene Chr4:101227638-101273397 (-)
DBA/2J MGP_DBA2J_G0028263
protein coding gene Chr4:91091666-91127360 (-)
FVB/NJ MGP_FVBNJ_G0028230
protein coding gene Chr4:89956713-89992209 (-)
LP/J MGP_LPJ_G0028363
protein coding gene Chr4:94944353-94981866 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028259
protein coding gene Chr4:106991256-107030876 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028908
protein coding gene Chr4:93769535-93806977 (-)
PWK/PhJ MGP_PWKPhJ_G0027309
protein coding gene Chr4:89249687-89289012 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027129
protein coding gene Chr4:91182337-91219080 (-)
WSB/EiJ MGP_WSBEiJ_G0027662
protein coding gene Chr4:93928601-93968418 (-)



Homology
more
  • Human Ortholog
    PLAA, phospholipase A2 activating protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PLAA, phospholipase A2 activating protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DOA1, NDMSBA, PLA2P, PLAP
  • Links
    NCBI Gene ID: 9373
    neXtProt AC: NX_Q9Y263
    UniProt: Q9Y263

  • Chr Location
    9p21.2; chr9:26903370-26947473 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3138
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PLAA
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 2 alleles in 3 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    25
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    1
  • Gene trapped
    18
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    3 involving Plaa
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
Homozygous KO is embryonic lethal. A hypomorphic homozygous point mutation affects neuromuscular junctions and Purkinje cell development, causing early-onset neurodysfunction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028577 Ensembl Gene Model | MGI Sequence Detail 35731 C57BL/6J ±  kb
transcript ENSMUST00000107107 Ensembl | MGI Sequence Detail 2784 Not Applicable  
polypeptide ENSMUSP00000102724 Ensembl | MGI Sequence Detail 794 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    cDNA 19
    Primer pair 2

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-28104, MGI:1277105, MGI:2140330, MGI:2140438, MGI:2140559
References
more
  • Summaries
    All 42
    Developmental Gene Expression 1
    Gene Ontology 9
    Phenotypes 11
  • Earliest
    J:28587 Clark MA, et al., Cloning of a phospholipase A2-activating protein. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5418-22
  • Latest
    J:250427 Falik Zaccai TC, et al., Phospholipase A2-activating protein is associated with a novel form of leukoencephalopathy. Brain. 2017 Feb;140(2):370-386

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory