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Pls1 Gene Detail
Summary
  • Symbol
    Pls1
  • Name
    plastin 1 (I-isoform)
  • Synonyms
    I-fimbrin
  • Feature Type
    protein coding gene
  • IDs
    MGI:104809
    NCBI Gene: 102502
  • Gene Overview
    MyGene.info: PLS1
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:95752642-95845306 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 50.22 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1119 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104809
protein coding gene Chr9:95752642-95845311 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035138
protein coding gene Chr9:96891377-96992745 (-)
A/J MGP_AJ_G0035119
protein coding gene Chr9:93532875-93626435 (-)
AKR/J MGP_AKRJ_G0035051
protein coding gene Chr9:95796561-95895181 (-)
BALB/cJ MGP_BALBcJ_G0035112
protein coding gene Chr9:93216160-93313533 (-)
C3H/HeJ MGP_C3HHeJ_G0034822
protein coding gene Chr9:96229706-96325818 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035632
protein coding gene Chr9:99669904-99771227 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032533
protein coding gene Chr9:91391609-91450106 (-)
CAST/EiJ MGP_CASTEiJ_G0034134
protein coding gene Chr9:95958250-96055896 (-)
CBA/J MGP_CBAJ_G0034790
protein coding gene Chr9:103125866-103245235 (-)
DBA/2J MGP_DBA2J_G0034952
protein coding gene Chr9:93056998-93151798 (-)
FVB/NJ MGP_FVBNJ_G0034900
protein coding gene Chr9:91904553-91998604 (-)
LP/J MGP_LPJ_G0035031
protein coding gene Chr9:97154084-97252962 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034939
protein coding gene Chr9:105134207-105241842 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035654
protein coding gene Chr9:96028421-96124350 (-)
PWK/PhJ MGP_PWKPhJ_G0033841
protein coding gene Chr9:93213873-93307416 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033676
protein coding gene Chr9:96029359-96129442 (-)
WSB/EiJ MGP_WSBEiJ_G0034254
protein coding gene Chr9:95892727-95996156 (-)



Homology
more
  • Human Ortholog
    PLS1, plastin 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PLS1, plastin 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 5357
    neXtProt AC: NX_Q14651
    UniProt: Q14651

  • Chr Location
    3q23; chr3:142596387-142713664 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 68270
    1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PLS1
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation for this gene leads to altered intestinal morphology and physiology, increased brush border fragility and susceptibility to induced colitis, as well as a moderate and progressive form of hearing loss associated with defects in stereocilia morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 102502 NCBI Gene Model | MGI Sequence Detail 92665 C57BL/6J ±  kb
    transcript NM_001033210 RefSeq | MGI Sequence Detail 3697 C57BL/6  
    polypeptide Q3V0K9 UniProt | EBI | MGI Sequence Detail 630 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 3
      cDNA 28

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-28103, MGI:2143039
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:26070 Chafel MM, et al., Sequential expression and differential localization of I-, L-, and T-fimbrin during differentiation of the mouse intestine and yolk sac. Dev Dyn. 1995 Jun;203(2):141-51
    • Latest
      J:242628 Krey JF, et al., Plastin 1 widens stereocilia by transforming actin filament packing from hexagonal to liquid. J Cell Biol. 2016 Nov 21;215(4):467-482

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory