About   Help   FAQ
Lcp1
Gene Detail
Symbol

Name
ID
Lcp1
lymphocyte cytosolic protein 1
MGI:104808
Synonyms
D14Ertd310e, L-fimbrin, L-plastin, Pls2
Feature Type
protein coding gene
Genetic Map
Chromosome 14
39.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:75131101-75230842 bp, + strand
From VEGA annotation of GRCm38

  99742 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:80174  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: plastin
Gene Tree: Lcp1

Human
homologs
Human Homolog LCP1, lymphocyte cytosolic protein 1 (L-plastin)
NCBI Gene ID 3936
neXtProt AC  NX_P13796
Human Synonyms  CP64, HEL-S-37, LC64P, LPL, L-PLASTIN, PLS2
Human Chr (Location)  13q14.3; chr13:46125923-46182324 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased susceptibility to S. aureus infection, defective neutrophil killing of S. aureus, and impaired adhesion-dependent respiratory bursts in neutrophils.
 
Interactions
Lcp1 interacts with 230 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process actin filament bundle assembly, cell migration, ...
Component actin cytoskeleton, actin filament, ...
Function actin binding, actin filament binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (25)    Tissues (4)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 23
RT-PCR 2
cDNA source data(33)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(35) cDNA(33) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000024579 (Evidence)
Ensembl Gene ModelENSMUSG00000021998 (Evidence)
Entrez Gene18826 (Evidence)
DFCITC1624456, TC1573951
DoTSDT.101181825, DT.101187779, DT.101366127, DT.101355684, DT.94392661, DT.101376438, DT.91397259, DT.535992
NIA Mouse Gene IndexU015856
Consensus CDS ProjectCCDS27276.1
International Mouse Knockout Project StatusLcp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024579 VEGA Gene Model | MGI Sequence Detail 99742 C57BL/6J ±  kb
transcript OTTMUST00000060380 VEGA | MGI Sequence Detail 3841 Not Applicable 
polypeptide OTTMUSP00000029452 VEGA | MGI Sequence Detail 627 Not Applicable 

For the selected sequences
All sequences(119) RefSeq(16) UniProt(19)
Polymorphisms
SNPs within 2kb(704 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001589 Actinin-type, actin-binding, conserved site
InterPro IPR001715 Calponin homology domain
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
Protein Ontology PR:000009732 plastin-2
References
(Earliest) J:26070 Chafel MM, et al., Sequential expression and differential localization of I-, L-, and T-fimbrin during differentiation of the mouse intestine and yolk sac. Dev Dyn. 1995 Jun;203(2):141-51
(Latest) J:209869 Deady LE, et al., L-plastin is essential for alveolar macrophage production and control of pulmonary pneumococcal infection. Infect Immun. 2014 May;82(5):1982-93
All references(47)
Other
accession IDs
MGD-MRK-28102, MGI:1261889, MGI:2145820

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory