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Pls3 Gene Detail
Summary
  • Symbol
    Pls3
  • Name
    plastin 3 (T-isoform)
  • Synonyms
    T-fimbrin
  • Feature Type
    protein coding gene
  • IDs
    MGI:104807
    NCBI Gene: 102866
  • Gene Overview
    MyGene.info: PLS3
Location & Maps
more
  • Sequence Map
    ChrX:75785654-75875182 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      89529 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 38.30 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PLS3, plastin 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PLS3, plastin 3
    Orthology source: HomoloGene
  • Synonyms
    BMND18, T-plastin
  • Links
    NCBI Gene ID: 5358
    neXtProt AC: NX_P13797

  • Chr Location
    Xq23; chrX:115560850-115650861 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 128200
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: PLS3
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 2 genetic backgrounds
    23 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    28
  • Gene trapped
    22
  • Targeted
    6
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017411 VEGA Gene Model | MGI Sequence Detail 89529 C57BL/6J ±  kb
transcript OTTMUST00000042207 VEGA | MGI Sequence Detail 3032 Not Applicable  
polypeptide OTTMUSP00000018967 VEGA | MGI Sequence Detail 639 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    323 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 169
    cDNA 169

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-28101, MGI:2147843, MGI:2147947
References
more
  • Summaries
    All 39
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:26070 Chafel MM, et al., Sequential expression and differential localization of I-, L-, and T-fimbrin during differentiation of the mouse intestine and yolk sac. Dev Dyn. 1995 Jun;203(2):141-51
  • Latest
    J:229226 Amaniti EM, et al., Expansion of the piriform cortex contributes to corticothalamic pathfinding defects in Gli3 conditional mutants. Cereb Cortex. 2015 Feb;25(2):460-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory