Snrpb2 MGI Mouse Gene Detail - MGI:104805 - U2 small nuclear ribonucleoprotein B

Symbol

Snrpb2
Name

U2 small nuclear ribonucleoprotein B
Synonyms

2810052G09Rik

Feature Type

protein coding gene
IDs

MGI:104805
NCBI Gene: 20639
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr2:142904989-142913972 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 70.89 cM
Mapping Data

2 experiments

SNPs within 2kb

213 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104805	protein coding gene	Chr2:142904959-142914773 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026574	protein coding gene	Chr2:147074399-147084207 (+)
A/J	MGP_AJ_G0026538	protein coding gene	Chr2:141108143-141117967 (+)
AKR/J	MGP_AKRJ_G0026512	protein coding gene	Chr2:145184933-145194747 (+)
BALB/cJ	MGP_BALBcJ_G0026550	protein coding gene	Chr2:141582827-141592641 (+)
C3H/HeJ	MGP_C3HHeJ_G0026293	protein coding gene	Chr2:145737785-145747586 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026995	protein coding gene	Chr2:151502928-151512737 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024372	protein coding gene	Chr2:135377853-135388100 (+)
CAST/EiJ	MGP_CASTEiJ_G0025754	protein coding gene	Chr2:146073405-146083466 (+)
CBA/J	MGP_CBAJ_G0026273	protein coding gene	Chr2:157046747-157056552 (+)
DBA/2J	MGP_DBA2J_G0026407	protein coding gene	Chr2:140444319-140454393 (+)
FVB/NJ	MGP_FVBNJ_G0026371	protein coding gene	Chr2:139008806-139018621 (+)
LP/J	MGP_LPJ_G0026511	protein coding gene	Chr2:147256960-147266774 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026391	protein coding gene	Chr2:161247411-161257224 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027050	protein coding gene	Chr2:145192800-145203278 (+)
PWK/PhJ	MGP_PWKPhJ_G0025490	protein coding gene	Chr2:140090271-140100987 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025291	protein coding gene	Chr2:144240413-144250426 (+)
WSB/EiJ	MGP_WSBEiJ_G0025827	protein coding gene	Chr2:146192173-146201984 (+)

Human Ortholog

SNRPB2, small nuclear ribonucleoprotein polypeptide B2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SNRPB2, small nuclear ribonucleoprotein polypeptide B2
Synonyms

Msl1, U2B''
Links

HGNC:11155

NCBI Gene ID: 6629

neXtProt AC: NX_P08579

UniProt: P08579
Chr Location

20p12.1; chr20:16729961-16742564 (+) GRCh38

MGI Vertebrate Homology

Snrpb2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SNRPB2
Gene Tree

Snrpb2

Diseases

1 with human SNRPB2 associations

				Human Disease	Mouse Models
				connective tissue disease IDs connective tissue disease DOID:65 MESH:D003240 NCI:C26729 UMLS_CUI:C0009782

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

5
Radiation induced

1
Genomic Mutations

2 involving Snrpb2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available

less

All GO Annotations

25
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

756
Tissues

25
cDNA Data

9
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase snrpb2

less

All Sequences

47
RefSeq

2
UniProt

4
CCDS

CCDS16808.1

Ensembl

ENSMUSG00000008333 (Evidence)
NCBI Gene

20639

			Length	Strain/Species	Flank
genomic	20639	NCBI Gene Model \| MGI Sequence Detail	8984	C57BL/6J	± kb
transcript	NM_021335	RefSeq \| MGI Sequence Detail	1230	C57BL/6
polypeptide	Q9CQI7	UniProt \| EBI \| MGI Sequence Detail	225	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000015341 U2 small nuclear ribonucleoprotein B''

(term hierarchy)
InterPro Domains

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR045164 RNA-binding region-containing protein RBM41/RNPC3

IPR000504 RNA recognition motif domain

IPR034564 U2 small nuclear ribonucleoprotein B'', RNA recognition motif 1

IPR034562 U2 small nuclear ribonucleoprotein B'', RNA recognition motif 2

less

All nucleic 14

cDNA 11

Primer pair 3

Microarray probesets 6

less

MGD-MRK-28099, MGI:1914458

Summaries

All 37

Developmental Gene Expression 5

Gene Ontology 6

Phenotypes 8
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:174767 Tang F, et al., Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208

TSS for Snrpb2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20501	Chr2:142904951-142904997 (+)	-15 bp
Tssr20502	Chr2:142913418-142913435 (+)	8,438 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23